Abstract
The field of digital pathology is evolving very quickly: there is an increasing implication of laboratories and imaging companies in the biomedical field of histology. For our part we propose a digital imaging tool based on optical interferometry with short coherence length light sources (OCT). This instrument provides, without preparation or contrast agents , virtual sections of biological tissues with a field of view (1cm 2) and spatial resolution (approximately 1 micron in 3-D) suitable for histology. We show the relevance of this approach by comparing our images obtained in minutes during surgery with histological sections obtained after a few days. In these studies we worked on fixed tissue, fresh tissue in vivo or ex vivo. Finally, an endoscopic probe based on the same principle has been validated ex-vivo for use inside the bodies of patients.
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Fujimoto, J.G., Brezinski, M.E., Tearney, G.J., Boppart, S.A., Bouma, B.E., Hee, M.R., Southern, J.F., Swanson, E.A.: Optical biopsy and imaging using optical coherence tomography. Nature Med. 1, 970–972 (1995)
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© 2012 Springer Berlin Heidelberg
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Antoine, M. et al. (2012). Intra-Operative Ex-Situ and In-Situ Optical Biopsy Using Light-CT. In: Loménie, N., Racoceanu, D., Gouaillard, A. (eds) Advances in Bio-Imaging: From Physics to Signal Understanding Issues. Advances in Intelligent and Soft Computing, vol 120. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-25547-2_7
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DOI: https://doi.org/10.1007/978-3-642-25547-2_7
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Publisher Name: Springer, Berlin, Heidelberg
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