Abstract
Bioconjugates on the basis of silver nanoparticles and antimicrobial proline-rich peptide C-Bac3.4 were synthesized. The biological activity of the bioconjugates synthesized was tested in comparison with activity of their constituents ?? nanoparticles and the peptide. It was found that the nanoparticles-peptide conjugates exhibited the pronounced antimicrobial activity against bacteria including that resist to conventional antibiotics ?? drug-resistant clinical isolate of Pseudomonas aeruginosa and the methicillin resistant strain of Staphylococcus aureus. It was shown that bioconjugates studied did not exhibit the pronounced membrano-lytic activity typical of most of antimicrobial peptides. The results obtained let us make the conclusion that the bioconjugates synthesized are characterized by the properties which are different from the properties of their constituents the antimicrobial peptide and silver nanoparticles
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Golubeva, O.Y., Shamova, O.V., Orlov, D.S., Yamshchikova, E.V., Boldina, A.S., Kokryakov, V.N. (2012). Synthesis and investigation of silver-peptide bioconjugates and investigation in their antimicrobial activity. In: Böllinghaus, T., Lexow, J., Kishi, T., Kitagawa, M. (eds) Materials Challenges and Testing for Supply of Energy and Resources. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-23348-7_15
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DOI: https://doi.org/10.1007/978-3-642-23348-7_15
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