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Myofibroblasts and Interactions with Other Cells: Contribution of the Tissue Engineering

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Dupuytren’s Disease and Related Hyperproliferative Disorders

Abstract

Myofibroblasts are known to contract and secrete new matrix, but their interactions with other cells are still not well understood. The skin model that we have developed using places cells in a very similar context to that found in vivo. This model has allowed understanding the interactions existing between myofibroblasts and epidermal cells. In contrast to fibroblasts, myofibroblasts cannot support the growth of the epidermis and its differentiation. Fibrotic keratinocytes did however induce the overproduction of matrix by myofibroblasts when compared to normal keratinocytes. Interaction of epithelial cells and fibroblasts is thus vital during the development of normal and pathological scars.

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Acknowledgments

These studies were supported by the Canadian Institute of Health Research and Foundation des Hopitaux Enfant-Jésus/Saint-Sacrement. VM was a recipient of scholarships from FRSQ.

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Authors and Affiliations

  1. Centre LOEX de l’Université Laval, Génie tissulaire et régénération: LOEX du Centre de recherche FRSQ du Centre hospitalier affilié universitaire de Québec, Québec, QC, Canada

    Véronique Moulin, Judith Bellemare & Daniele Bergeron

  2. Département de Chirurgie, Faculté de Médecine, Université Laval, Québec, QC, Canada

    Véronique Moulin, Judith Bellemare & Daniele Bergeron

  3. Centre hospitalier affilié Universitaire de Québec, Québec, QC, Canada

    Herve Genest & Michel Roy

  4. Complexe Hospitalier de la Sagamie, Chicoutimi, QC, Canada

    Carlos Lopez-Vallé

Authors
  1. Véronique Moulin
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  2. Judith Bellemare
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  3. Daniele Bergeron
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  4. Herve Genest
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  5. Michel Roy
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  6. Carlos Lopez-Vallé
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Corresponding author

Correspondence to Véronique Moulin .

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Editors and Affiliations

  1. The Hand Center, S Old Dixie Highway 1002, Jupiter, 33458, Florida, USA

    Charles Eaton

  2. Strahlenzentrum Hamburg, Langenhorner Chaussee 369, Hamburg, 22419, Germany

    M. Heinrich Seegenschmiedt

  3. Manchester Interdisciplinary Biocentre, Plastic & Reconstructive Surgery, University of Manchester, Princess Street 131, Manchester, M1 7DN, United Kingdom

    Ardeshir Bayat

  4. Faculty of Medicine, Dept. of Pathology and Immunology, University of Geneva, Rue Michel-Servet 1, Geneva, 1211, Switzerland

    Giulio Gabbiani

  5. Medical Center, Department of Plastic Surgery, University of Groningen, Hanzeplein 1, Groningen, 9713 GZ, Netherlands

    Paul Werker

  6. Dupuytren e.V., Westerbuchberg 60b, Übersee, 83236, Germany

    Wolfgang Wach

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© 2012 Springer-Verlag Berlin Heidelberg

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Moulin, V., Bellemare, J., Bergeron, D., Genest, H., Roy, M., Lopez-Vallé, C. (2012). Myofibroblasts and Interactions with Other Cells: Contribution of the Tissue Engineering. In: Eaton, C., Seegenschmiedt, M., Bayat, A., Gabbiani, G., Werker, P., Wach, W. (eds) Dupuytren’s Disease and Related Hyperproliferative Disorders. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-22697-7_9

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  • DOI: https://doi.org/10.1007/978-3-642-22697-7_9

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-22696-0

  • Online ISBN: 978-3-642-22697-7

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