Jessner’s Solution

Abstract

Jessner’s solution has been used for over 100 years as a therapeutic agent to treat hyperkeratotic epidermal lesions [1]. This superficial peeling agent constitutes a mixture of salicylic acid, resorcinol, and lactic acid in 95% ethanol. Jessner’s solution causes loss of corneocyte cohesion and induces intercellular and intracellular edema. Jessner’s solution typically induces wounding to the level of the papillary dermis. In the early twentieth century, resorcinol (a key component of Jessner’s peels) was used in concentrations of 10–50%; however, such high concentrations of resorcinol were associated with side effects such as allergic contact dermatitis, irritant contact dermatitis, and skin discoloration. Subsequently, Jessner’s solution was formulated by Dr. Max Jessner to lower the concentrations of any one agent contained in the mixture and to enhance its overall effects as a keratolytic agent.