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Occupational Exposure to Nanoparticles and Medical Safety

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Nanoethics and Nanotoxicology

Abstract

The problem of occupational exposure to nanoparticles (NP) has raised many questions which remain unanswered today: When airborne NPs, either dissociated or more commonly in the form of aggregates, are inhaled by humans, will they produce a biological and/or tissular response where they are deposited, i.e., in the respiratory tract, or at some distance from the deposition area, i.e., an indirect effect secondary to the inflammatory response of the respiratory tract or a direct effect due to translocation of nanoparticles through the biological membranes?

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References

  1. Comité de la prévention et de la précaution (CPP): Nanotechnologies, nanoparticules: quels dangers, quels risques? Ministère de l’Ecologie et du Développement durable, 1–64, www.ecologie.gouv.fr (2006)

  2. W.G. Kreyling, M. Semmler-Behnke, J. Seitz, W. Scymczak, A. Wenk, P. Mayer, S. Takenaka, G. Oberdorster: Size dependence of the translocation of inhaled iridium and carbon nanoparticle aggregates from the lung of rats to the blood and secondary target organs. Inhal. Toxicol. 21 (S1), 55–60 (2009)

    Google Scholar 

  3. T. Xia, N. Li, A.E. Nel: Potential health impact of nanoparticles. Annu. Rev. Public Health 30, 137–150 (2009)

    Article  Google Scholar 

  4. A. Nel, T. Xia, L. Mädler, N. Li: Toxic potential of materials at the nano level. Science 311, 622–627 (2006)

    Article  ADS  Google Scholar 

  5. K. Donaldson, P.J. Borm, G. Oberdorster, K.E. Pinkerton, V. Stone, C.L. Tran: Concordance between in vitro and in vivo dosimetry in the proinflammatory effects of low-toxicity, low-solubility particles: The key role of the proximal alveolar region. Inhal. Toxicol. 20, 53–62 (2008)

    Article  Google Scholar 

  6. G. Oberdorster, E. Oberdorster, J. Oberdorster: Nanotoxicology: An emerging discipline evolving from studies of ultrafine particles. Environ. Health Perspect. 113, 823–839 (2005)

    Article  Google Scholar 

  7. M.F. Stanton, C. Wrench: Mechanisms of mesothelioma induction with asbestos and fibrous glass. J. Natl. Cancer Inst. 48, 797–821 (1972)

    Google Scholar 

  8. M.W. Frampton: Systemic and cardiovascular effects of airway injury and inflammation: Ultrafine particle exposure in humans. Environ. Health Perspect. 109 (Suppl. 4), 529–532 (2001)

    Article  Google Scholar 

  9. A. Nemmar, P.H. Hoet, B. Vanquickenborne, D. Dinsdale, M. Thomeer, M.F. Hoylaerts, H. Vanbilloen, L. Mortelmans, B. Nemery: Passage of inhaled particles into the blood circulation in humans. Circulation 105, 411–414 (2002)

    Article  Google Scholar 

  10. C.C. Daigle, D.C. Chalupa, F.R. Gibb, P.E. Morrow, G. Oberdorster, M.J. Utell, M.W. Frampton: Ultrafine particle deposition in humans during rest and exercise. Inhal. Toxicol. 15, 539–552 (2003)

    Article  Google Scholar 

  11. A.P. Pietropaoli, M.W. Frampton, R.W. Hyde, P.E. Morrow, G. Oberdorster, C. Cox, D.M. Speers, L.M. Frasier, D.C. Chalupa, L.S. Huang, M.J. Utell: Pulmonary function, diffusing capacity, and inflammation in healthy and asthmatic subjects exposed to ultrafine particles. Inhal. Toxicol. 16 (Suppl. 1), 59–72 (2004)

    Article  Google Scholar 

  12. D.C. Chalupa, P.E. Morrow, G. Oberdorster, M.J. Utell, M.W. Frampton: Ultrafine particle deposition in subjects with asthma. Environ. Health Perspect. 112, 879–882 (2004)

    Article  Google Scholar 

  13. M.W. Frampton, M.J. Utell, W. Zareba, G. Oberdorster, C. Cox, L.S. Huang, P.E. Morrow, F.E. Lee, D. Chalupa, L.M. Frasier, D.M. Speers, J. Stewart: Effects of exposure to ultrafine carbon particles in healthy subjects and subjects with asthma. Res. Respir. Health Eff. Inst. 126, 1–47 (2004)

    Google Scholar 

  14. W.S. Beckett, D.F. Chalupa, A. Pauly-Brown, D.M. Speers, J.C. Stewart, M.W. Frampton, M.J. Utell, L.S. Huang, C. Cox, W. Zareba, G. Oberdorster: Comparing inhaled ultrafine versus fine zinc oxide particles in healthy adults: A human inhalation study. Am. J. Respir. Crit. Care Med. 171, 1129–1135 (2005)

    Article  Google Scholar 

  15. M.W. Frampton: Inflammation and airborne particles. Clin. Occup. Environ. Med. 5, 797–815 (2006)

    Google Scholar 

  16. H.C. Routledge, S. Manney, R.M. Harrison, J.G. Ayres, J.N. Townend: Effect of inhaled sulphur dioxide and carbon particles on heart rate variability and markers of inflammation and coagulation in human subjects. Heart 92, 220–227 (2006)

    Article  Google Scholar 

  17. P. Wiebert, A. Sanchez-Crespo, R. Falk, K. Philipson, A. Lundin, S. Larsson, W. Moller, W.G. Kreyling, M. Svartengren: No significant translocation of inhaled 35-nm carbon particles to the circulation in humans. Inhal. Toxicol. 18, 741–747 (2006)

    Article  Google Scholar 

  18. N.L. Mills, N. Amin, S.D. Robinson, A. Anand, J. Davies, D. Patel, J.M. de la Fuente, F.R. Cassee, N.A. Boon, W. Macnee, A.M. Millar, K. Donaldson, D.E. Newby: Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am. J. Respir. Crit. Care Med. 173, 426–431 (2006)

    Article  Google Scholar 

  19. J. Londahl, A. Massling, J. Pagels, E. Swietlicki, E. Vaclavik, S. Loft: Size-resolved respiratory-tract deposition of fine and ultrafine hydrophobic and hygroscopic aerosol particles during rest and exercise. Inhal. Toxicol. 19, 109–116 (2007)

    Article  Google Scholar 

  20. W. Moller, K. Felten, K. Sommerer, G. Scheuch, G. Meyer, P. Meyer, K. Haussinger, W.G. Kreyling: Deposition, retention, and translocation of ultrafine particles from the central airways and lung periphery. Am. J. Respir. Crit. Care Med. 177, 426–432 (2008)

    Article  Google Scholar 

  21. A.P. Shah, A.P. Pietropaoli, L.M. Frasier, D.M. Speers, D.C. Chalupa, J.M. Delehanty, L.S. Huang, M.J. Utell, M.W. Frampton: Effect of inhaled carbon ultrafine particles on reactive hyperemia in healthy human subjects. Environ. Health Perspect. 116, 375–380 (2008)

    Article  Google Scholar 

  22. W. Zareba, J.P. Couderc, G. Oberdorster, D. Chalupa, C. Cox, L.S. Huang, A. Peters, M.J. Utell, M.W. Frampton: ECG parameters and exposure to carbon ultrafine particles in young healthy subjects. Inhal. Toxicol. 21, 223–233 (2009)

    Article  Google Scholar 

  23. IARC 2006: http://monographs.iarc.fr/ENG/Meetings/93-carbonblack.pdf, http://monographs.iarc.fr/ENG/Meetings/93-titaniumdioxide.pdf

  24. K. Gardiner, M. van Tongeren, M. Harrington: Respiratory health effects from exposure to carbon black: Results of the phase 2 and 3 cross-sectional studies in the European carbon black manufacturing industry. Occup. Environ. Med. 58, 496–503 (2001)

    Article  Google Scholar 

  25. M.J. Van Tongeren, K. Gardiner, C.E. Rossiter, J. Beach, P. Harber, M.J. Harrington: Longitudinal analyses of chest radiographs from the European Carbon Black Respiratory Morbidity Study. Eur. Respir. J. 20, 417–425 (2002)

    Article  Google Scholar 

  26. K. Gardiner, N.W. Trethowan, J.M. Harrington, C.E. Rossiter, I.A. Calvert: Respiratory health effects of carbon black: A survey of European carbon black workers. Br. J. Ind. Med. 50, 1082–1096 (1993)

    Google Scholar 

  27. J.T. Hodgson, R.D. Jones: A mortality study of carbon black workers employed at five United Kingdom factories between 1947 and 1980. Arch. Environ. Health 40, 261–268 (1985)

    Google Scholar 

  28. T. Sorahan, L. Hamilton, M. van Tongeren, K. Gardiner, J.M. Harrington: A cohort mortality study of UK carbon black workers, 1951–1996. Am. J. Ind. Med. 39, 158–170 (2001)

    Article  Google Scholar 

  29. NIOSH Evaluation of Health Hazard and Recommendations for Occupational Exposure to Titanium Dioxide 2005: www.cdc.gov/niosh/review/public/TIo2/pdfs/TIO2Draft.pdf

  30. J.L. Chen, W.E. Fayerweather: Epidemiologic study of workers exposed to titanium dioxide. J. Occup. Med. 30, 937–942 (1988)

    Article  Google Scholar 

  31. J.P. Fryzek, B. Chadda, D. Marano, K. White, S. Schweitzer, J.K. McLaughlin, W.J. Blot: A cohort mortality study among titanium dioxide manufacturing workers in the United States. J. Occup. Environ. Med./Am. Coll. Occup. Environ. Med. 45, 400–409 (2003)

    Google Scholar 

  32. J.J. Beaumont, M.S. Sandy, C.D. Sherman: Titanium dioxide and lung cancer. J. Occup. Environ. Med. 46, 759 (2004); erratum: 1189

    Google Scholar 

  33. P. Boffetta, V. Gaborieau, L. Nadon, M.F. Parent, E. Weiderpass, J. Siemiatycki: Exposure to titanium dioxide and risk of lung cancer in a population-based study from Montreal. Scand. J. Work. Environ. Health. 27, 227–232 (2001)

    Google Scholar 

  34. P. Boffetta, A. Soutar, J.W. Cherrie, F. Granath, A. Andersen, A. Anttila, M. Blettner, V. Gaborieau, S.J. Klug, S. Langard, D. Luce, F. Merletti, B. Miller, D. Mirabelli, E. Pukkala, H.O. Adami, E. Weiderpass: Mortality among workers employed in the titanium dioxide production industry in Europe. Cancer Causes Control 15, 697–706 (2004)

    Article  Google Scholar 

  35. Y. Song, X. Li, X. Du: Exposure to nanoparticles is related to pleural effusion, pulmonary fibrosis and granuloma. Eur. Respir. J. 34, 559–567 (2009)

    Article  Google Scholar 

  36. C.A. Pope, R.T. Burnett, G.D. Thurston, M.J. Thun, E.E. Calle, D. Krewski, J.J. Godleski: Cardiovascular mortality and long-term exposure to particulate air pollution: Epidemiological evidence of general pathophysiological pathways of disease. Circulation 109, 71–77 (2004)

    Article  Google Scholar 

  37. J.M. Antonini, A.B. Lewis, J.R. Roberts, D.A. Whaley: Pulmonary effects of welding fumes: Review of worker and experimental animal studies. Am. J. Ind. Med. 43, 350–360 (2003)

    Article  Google Scholar 

  38. A. Peretz, J.H. Sullivan, D.F. Leotta, C.A. Trenga, F.N. Sands, J. Allen, C. Carlsten, C.W. Wilkinson, E.A. Gill, J.D. Kaufman: Diesel exhaust inhalation elicits acute vasoconstriction in vivo. Environ. Health Perspect. 116, 937–942 (2008)

    Article  Google Scholar 

  39. E.V. Brauner, L. Forchhammer, P. Moller, J. Simonsen, M. Glasius, P. Wahlin, O. Raaschou-Nielsen, S. Loft: Exposure to ultrafine particles from ambient air and oxidative stress-induced DNA damage. Environ. Health Perspect. 115, 1177–1182 (2007)

    Article  Google Scholar 

  40. J.M. Samet, A. Rappold, D. Graff, W.E. Cascio, J.H. Berntsen, Y.C. Huang, M. Herbst, M. Bassett, T. Montilla, M.J. Hazucha, P.A. Bromberg, R.B. Devlin: Concentrated ambient ultrafine particle exposure induces cardiac changes in young healthy volunteers. Am. J. Respir. Crit. Care Med. 179, 1034–1042 (2009)

    Article  Google Scholar 

  41. S.A. Kharitonov, P.J. Barnes: Exhaled biomarkers. Chest 130, 1541–1546 (2006)

    Google Scholar 

  42. B. Balbi, P. Pignatti, M. Corradi, P. Baiardi, L. Bianchi, G. Brunetti, A. Radaeli, G. Moscato, A. Mutti, A. Spanevello, M. Malerba: Bronchoalveolar lavage, sputum and exhaled clinically relevant inflammatory markers: Values in healthy adults. Eur. Respir. J. 30, 769–781 (2007)

    Article  Google Scholar 

  43. M.C. Levesque, D.W. Hauswirth, S. Mervin-Blake, C.A. Fernandez, K.B. Patch, K.M. Alexander, S. Allgood, P.D. McNair, A.S. Allen, J.S. Sundy: Determinants of exhaled nitric oxide levels in healthy, nonsmoking African American adults. J. Allergy Clin. Immunol. 121, 396–402, e3 (2008)

    Google Scholar 

  44. I. Horvath, J. Hunt, P.J. Barnes, K. Alving, A. Antczak, E. Baraldi, G. Becher, W.J. van Beurden, M. Corradi, R. Dekhuijzen, R.A. Dweik, T. Dwyer, R. Effros, S. Erzurum, B. Gaston, C. Gessner, A. Greening, L.P. Ho, J. Hohlfeld, Q. Jobsis, D. Laskowski, S. Loukides, D. Marlin, P. Montuschi, A.C. Olin, A.E. Redington, P. Reinhold, E.L. van Rensen, I. Rubinstein, P. Silkoff, K. Toren, G. Vass, C. Vogelberg, H. Wirtz: Exhaled breath condensate: Methodological recommendations and unresolved questions. Eur. Respir. J. 26, 523–548 (2005)

    Article  Google Scholar 

  45. P.P. Rosias, C.M. Robroeks, A. Kester, G. Jden Hartog, W.K. Wodzig, G.T. Rijkers, L.J.V. Zimmermann, C.P. van Schayck, Q. Jobsis, E. Dompeling: Biomarker reproducibility in exhaled breath condensate collected with different condensers. Eur. Respir. J. 31, 934–942 (2008)

    Article  Google Scholar 

  46. H. Knobloch, G. Becher, M. Decker, P. Reinhold: Evaluation of H2O2 and pH in exhaled breath condensate samples: Methodical and physiological aspects. Biomarkers 13, 319–341 (2008)

    Article  Google Scholar 

  47. D.W. Hauswirth, J.S. Sundy, S. Mervin-Blake, C.A. Fernandez, K.B. Patch, K.M. Alexander, S. Allgood, P.D. McNair, M.C. Levesque: Normative values for exhaled breath condensate pH and its relationship to exhaled nitric oxide in healthy African Americans. J. Allergy Clin. Immunol. 122, 101–106 (2008)

    Article  Google Scholar 

  48. M.J. Cruz, S. Sanchez-Vidaurre, P.V. Romero, F. Morell, X. Munoz: Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate. Chest 135, 462–467 (2009)

    Article  Google Scholar 

  49. M. Malerba, B. Ragnoli, M. Corradi: Non-invasive methods to assess biomarkers of exposure and early stage of pulmonary disease in smoking subjects. Monaldi Arch. Chest Dis. 69, 128–133 (2008)

    Google Scholar 

  50. K. Hildebrandt, R. Ruckerl, W. Koenig, A. Schneider, M. Pitz, J. Heinrich, V. Marder, M. Frampton, G. Oberdorster, H.E. Wichmann, A. Peters: Short-term effects of air pollution: A panel study of blood markers in patients with chronic pulmonary disease. Part. Fibre Toxicol. 6, 25 (2009)

    Article  Google Scholar 

  51. M. Gulumian, P.J. Borm, V. Vallyathan, V. Castranova, K. Donaldson, G. Nelson, J. Murray: Mechanistically identified suitable biomarkers of exposure, effect, and susceptibility for silicosis and coal-worker’s pneumoconiosis: A comprehensive review. J. Toxicol. Environ. Health B Crit. Rev. 9, 357–395 (2006)

    Article  Google Scholar 

  52. D.M. Mannino, D. Thorn, A. Swensen, F. Holguin: Prevalence and outcomes of diabetes, hypertension and cardiovascular disease in COPD. Eur. Respir. J. 32, 962–969 (2008)

    Article  Google Scholar 

  53. F.L. Fimognari, S. Scarlata, M.E. Conte, R.A. Incalzi: Mechanisms of atherothrombosis in chronic obstructive pulmonary disease. Int. J. Chron. Obstruct. Pulmon. Dis. 3, 89–96 (2008)

    Google Scholar 

  54. R.D. Brook, B. Franklin, W. Cascio, Y. Hong, G. Howard, M. Lipsett, R. Luepker, M. Mittleman, J. Samet, S.C. Smith, I. Tager: Air pollution and cardiovascular disease: A statement for healthcare professionals from the Expert Panel on Population and Prevention Science of the American Heart Association. Circulation 109, 2655–2671 (2004)

    Article  Google Scholar 

  55. A. Peretz, E.C. Peck, T.K. Bammler, R.P. Beyer, J.H. Sullivan, C.A. Trenga, S. Srinouanprachnah, F.M. Farin, J.D. Kaufman: Diesel exhaust inhalation and assessment of peripheral blood mononuclear cell gene transcription effects: An exploratory study of healthy human volunteers. Inhal. Toxicol. 19, 1107–1119 (2007)

    Article  Google Scholar 

  56. A.J. Lucking, M. Lundback, N.L. Mills, D. Faratian, S.L. Barath, J. Pourazar, F.R. Cassee, K. Donaldson, N.A. Boon, J.J. Badimon, T. Sandstrom, A. Blomberg, D.E. Newby: Diesel exhaust inhalation increases thrombus formation in man. Eur. Heart J. 29, 3043–3051 (2008)

    Article  Google Scholar 

  57. H. Tornqvist, N.L. Mills, M. Gonzalez, M.R. Miller, S.D. Robinson, I.L. Megson, W. Macnee, K. Donaldson, S. Soderberg, D.E. Newby, T. Sandstrom, A. Blomberg: Persistent endothelial dysfunction in humans after diesel exhaust inhalation. Am. J. Respir. Crit. Care Med. 176, 395–400 (2007)

    Article  Google Scholar 

  58. N. Mills, N. Amin, S. Robinson, et al.: Do inhaled carbon nanoparticles translocate directly into the circulation in humans? Am. J. Respir. Crit. Care Med. 173, 426–431 (2006)

    Article  Google Scholar 

  59. N.L. Mills, S.D. Robinson, P.H. Fokkens, D.L. Leseman, M.R. Miller, D. Anderson, E.J. Freney, M.R. Heal, R.J. Donovan, A. Blomberg, T. Sandstrom, W. MacNee, N.A. Boon, K. Donaldson, D.E. Newby, F.R. Cassee: Exposure to concentrated ambient particles does not affect vascular function in patients with coronary heart disease. Environ. Health Perspect. 116, 709–715 (2008)

    Article  Google Scholar 

  60. A.J. Ghio, Y.C. Huang: Exposure to concentrated ambient particles (CAPs): A review. Inhal. Toxicol. 16, 53–59 (2004)

    Article  Google Scholar 

  61. M.W. Frampton, J.C. Stewart, G. Oberdorster, P.E. Morrow, D. Chalupa, A.P. Pietropaoli, L.M. Frasier, D.M. Speers, C. Cox, L.S. Huang, M.J. Utell: Inhalation of ultrafine particles alters blood leukocyte expression of adhesion molecules in humans. Environ. Health Perspect. 114, 51–58 (2006)

    Article  Google Scholar 

  62. P.P. Simeonova, A. Erdely: Engineered nanoparticle respiratory exposure and potential risks for cardiovascular toxicity: Predictive tests and biomarkers. Inhal. Toxicol. 21 (S1), 68–73 (2009)

    Google Scholar 

  63. A. Erdely, T. Hulderman, R. Salmen, A. Liston, P.C. Zeidler-Erdely, D. Schwegler-Berry, V. Castranova, S. Koyama, Y.A. Kim, M. Endo, P.P. Simeonova: Cross-talk between lung and systemic circulation during carbon nanotube respiratory exposure. Potential biomarkers. Nano Lett. 9, 36–43 (2009)

    Google Scholar 

  64. M. Semmler, J. Seitz, F. Erbe, P. Mayer, J. Heyder, G. Oberdorster, W.G. Kreyling: Long-term clearance kinetics of inhaled ultrafine insoluble iridium particles from the rat lung, including transient translocation into secondary organs. Inhal. Toxicol. 16, 453–459 (2004)

    Article  Google Scholar 

  65. P. Wiebert, A. Sanchez-Crespo, J. Seitz, R. Falk, K. Philipson, W.G. Kreyling, W. Moller, K. Sommerer, S. Larsson, M. Svartengren: Negligible clearance of ultrafine particles retained in healthy and affected human lungs. Eur. Respir. J. 28, 286–290 (2006)

    Article  Google Scholar 

  66. Z. Chen, H. Chen, H. Meng, G. Xing, X. Gao, B. Sun, X. Shi, H. Yuan, C. Zhang, R. Liu, F. Zhao, Y. Zhao, X. Fang: Bio-distribution and metabolic paths of silica coated CdSeS quantum dots. Toxicol. Appl. Pharmacol. 230, 364–371 (2008)

    Article  Google Scholar 

  67. X. He, H. Nie, K. Wang, W. Tan, X. Wu, P. Zhang: In vivo study of biodistribution and urinary excretion of surface-modified silica nanoparticles. Anal. Chem. 80, 9597–9603 (2008)

    Article  Google Scholar 

  68. M.T. Zhu, W.Y. Feng, Y. Wang, B. Wang, M. Wang, H. Ouyang, Y.L. Zhao, Z.F. Chai: Particokinetics and extrapulmonary translocation of intratracheally instilled ferric oxide nanoparticles in rats and the potential health risk assessment. Toxicol. Sci. 107, 342–351 (2009)

    Article  Google Scholar 

  69. A.A. Burns, J. Vider, H. Ow, E. Herz, O. Penate-Medina, M. Baumgart, S.M. Larson, U. Wiesner, M. Bradbury: Fluorescent silica nanoparticles with efficient urinary excretion for nanomedicine. Nano Lett. 9, 442–448 (2009)

    Article  ADS  Google Scholar 

  70. W.S. Cho, M. Cho, S.R. Kim, M. Choi, J.Y. Lee, B.S. Han, S.N. Park, M.K. Yu, S. Jon, J. Jeong: Pulmonary toxicity and kinetic study of Cy5.5-conjugated superparamagnetic iron oxide nanoparticles by optical imaging. Toxicol. Appl. Pharmacol 239, 106–115 (2009)

    Google Scholar 

  71. K. Sarlo, K.L. Blackburn, E.D. Clark, J. Grothaus, J. Chaney, S. Neu, J. Flood, D. Abbott, C. Bohne, K. Casey, C. Fryer, M. Kuhn: Tissue distribution of 20 nm, 100 nm and 1000 nm fluorescent polystyrene latex nanospheres following acute systemic or acute and repeat airway exposure in the rat. Toxicology 263, 117–126 (2009)

    Article  Google Scholar 

  72. A. Seaton: Nanotechnology and the occupational physician. Occup. Med. 56, 312–316 (2006)

    Article  Google Scholar 

  73. A. Seaton, L. Tran, R. Aitken, K. Donaldson: Nanoparticles, human health hazard and regulation. J. Roy. Soc. Interface 7 (Suppl. 1), S119–S129 (2010)

    Article  Google Scholar 

  74. M. Nasterlack, A. Zober, C. Oberlinner: Considerations on occupational medical surveillance in employees handling nanoparticles. Int. Arch. Occup. Environ. Health 81, 721–726 (2008)

    Article  Google Scholar 

  75. NIOSH: Interim guidance for medical screening and hazard surveillance for workers potentially exposed to engineered nanoparticles. Current Intelligence Bulletin 60. National Institute for Occupational Safety and Health. Department of Health and Human Services, February 2009. Publication No. 2009-116 (2009)

    Google Scholar 

  76. W.E. Halperin, J. Ratcliffe, T.M. Frazier, L. Wilson, S.P. Becker, P.A. Schulte: Medical screening in the workplace: Proposed principles. J. Occup. Med. 28, 547–552 (1986)

    Article  Google Scholar 

  77. P.A. Schulte, M.K. Schubauer-Berigan, C. Mayweather, C.L. Geraci, R. Zumwalde, J.L. McKernan: Issues in the development of epidemiologic studies of workers exposed to engineered nanoparticles. J. Occup. Environ. Med. 51, 323–335 (2009)

    Article  Google Scholar 

  78. M. Saunders: Transplacental transport of nanomaterials. Wiley Interdiscip. Rev. Nanomed. Nanobiotechnol. 1, 671–684 (2009)

    Article  Google Scholar 

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Brochard, P., Bloch, D., Pairon, JC. (2011). Occupational Exposure to Nanoparticles and Medical Safety. In: Houdy, P., Lahmani, M., Marano, F. (eds) Nanoethics and Nanotoxicology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-20177-6_11

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