Skip to main content
SpringerLink
Log in

Polymeric Nanocapsules: Concepts and Applications

  • Chapter
Nanocosmetics and Nanomedicines

Abstract

This chapter presents an overview of polymeric nanocapsules for dermatological and cosmetic applications, including their preparation methods, physicochemical characterization and models of supramolecular structures. Polymeric nanocapsules are advantageous because of their ability to control the release rate and the penetration/permeation of drugs and active ingredients in the skin. These properties can be modulated through manipulating the qualitative and quantitative compositions of formulations. The chemical nature of raw materials can define the supramolecular structures of the nanocapsule core and surface. In addition, polymeric nanocapsules protect the encapsulated drug or active ingredient from degradation by acting as reservoirs. Aqueous suspensions of polymeric nanocapsules are directly applied on the skin or used as intermediate products for semisolid formulations, such as hydrogels and emulgels. The rheological characteristics of semisolid formulations can be modified by the presence of nanocapsules. Polymeric nanocapsules are valuable devices for skin applications and represent a promising research field in terms of providing products to be explored by industry.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 129.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Couvreur, P., Barratt, G., Fattal, E., Legrand, P., Vauthier, C.: Nanocapsule technology: A review. Crit. Rev. Ther. Drug. Carrier Syst. 19, 99–134 (2002)

    Article  CAS  Google Scholar 

  2. Mora-Huertas, C.E., Fessi, H., Elaissari, A.: Polymer-based nanocapsules for drug delivery. Int. J. Pharm. 385, 113–142 (2010)

    Article  CAS  Google Scholar 

  3. Al Khoury-Fallouh, N., Roblot-Treupel, L., Fessi, H., Devissaguet, J.P., Puisieux, F.: Development of a new process for the manufacture of poly(isobutylcyanoacrylate) nanocapsules. Int. J. Pharm. 28, 125–136 (1986)

    Article  Google Scholar 

  4. Fessi, H., Puisieux, F., Devissaguet, J.P., Ammoury, N., Benita, S.: Nanocapsule formation by interfacial polymer deposition following solvent displacement. Int. J. Pharm. 55, R1–R4 (1989)

    Article  Google Scholar 

  5. Jäger, E., Venturini, C.G., Poletto, F.S., Colomé, L.M., Pohlmann, J.P.U., Bernardi, A., Battastini, A.M.O., Guterres, S.S., Pohlmann, A.R.: Sustained release from lipid-core nanocapsules by varying the core viscosity and the particle surface area. J. Biomed. Nanotechnol. 5, 130–140 (2009)

    Article  Google Scholar 

  6. Kulkamp, I.C., Paese, K., Guterres, S.S., Pohlmann, A.R.: Stabilization of lipoic acid by encapsulation in polymeric nanocapsules designed for cutaneous administration. Quim Nova 32, 2078–2084 (2009)

    Google Scholar 

  7. Moraes, C.M., de Matos, A.P., de Paula, E., Rosa, A.H., Fraceto, L.F.: Benzocaine loaded biodegradable poly-(d,l-lactide-co-glycolide) nanocapsules: factorial design and characterization. Mat. Sci. Eng. B Solid-State Mater Adv. Technol. 165, 243–246 (2009)

    CAS  Google Scholar 

  8. Calvo, P., Remuñán-López, C., Vila-Jato, J.L., Alonso, M.J.: Development of positively charged colloidal drug carriers: Chitosan coated polyester nanocapsules and submicron-emulsions. Colloid Polym. Sci. 275, 46–53 (1997)

    Article  CAS  Google Scholar 

  9. Guterres, S.S., Alves, M.P., Pohlmann, A.R.: Polymeric nanoparticles, nanospheres and nanocapsules for cutaneous applications. Drug Target Insights 2, 147–157 (2007)

    Google Scholar 

  10. Vettor, M., Bourgeois, S., Fessi, H., Pelletier, J., Perugini, P., Pavanetto, F., Bolzinger, M.A.: Skin absorption studies of octyl-methoxycinnamate loaded poly(D,L-lactide) nanoparticles: estimation of the UV filter distribution and release behaviour in skin layers. J. Microencapsul. 27, 253–262 (2010)

    Article  CAS  Google Scholar 

  11. Shin, J., Shin, K., Lee, H., Nam, J.B., Jung, J.E., Ryu, J.H., Han, J.H., Suh, K.D., Kim, Y.J., Shim, J., Kim, J., Han, S.H., Char, K., Kim, Y.K., Chung, J.H., Lee, M.J., Kang, B.C., Kim, J.W.: Non-invasive transdermal delivery route using electrostatically interactive biocompatible nanocapsules. Adv. Materials 22, 739–743 (2010)

    Article  CAS  Google Scholar 

  12. Ribier, A., Richart, P., Handjani, R.: Skin treating compsns. contg. active material in nano-capsules - having an oily core and non:biodegradable polymeric membrane. L’OREAL SA(OREA-C) Patent Number(s): FR2681248-A; EP557489-A; WO9305753-A; WO9305753-A1; FR2681248-A1; EP557489-A1; JP6502874-W; US5556617-A; EP557489-B1; DE69214425-E; ES2092699-T3; US5993831-A; JP2006052229-A (1993)

    Google Scholar 

  13. Quintanar, D., Allémann, E., Fessi, H., Doelker, E.: Preparation techniques and mechanisms of formation of biodegradable nanoparticles from preformed polymers. Drug Dev. Ind. Pharm. 24, 1113–1128 (1998)

    Article  Google Scholar 

  14. Hoffmann, D., Mayer, C.: Cross polarization induced by temporary adsorption: NMR investigations on nanocapsule dispersions. J. Chem. Phys. 112, 4242–4250 (2000)

    Article  CAS  Google Scholar 

  15. Mayer, C., Hoffmann, D., Wohlgemuth, M.: Structural analysis of nanocapsules by nuclear magnetic resonance. Int. J. Pharm. 242, 37–46 (2002)

    Article  CAS  Google Scholar 

  16. Jäger, A., Stefani, V., Guterres, S.S., Pohlmann, A.R.: Physico-chemical characterization of nanocapsule polymeric wall using fluorescent benzazole probes. Int. J. Pharm. 338, 297–305 (2007)

    Article  Google Scholar 

  17. Guterres, S.S., Weiss, V., Freitas, L.D., Pohlmann, A.R.: Influence of benzyl benzoate as oil core on the physicochemical properties of spray-dried powders from polymeric nanocapsules containing indomethacin. Drug Deliv. 7, 195–199 (2000)

    Article  CAS  Google Scholar 

  18. Weiss-Angeli, V., Poletto, F.S., Zancan, L.R., Baldasso, F., Pohlmann, A.R., Guterres, S.S.: Nanocapsules of octyl methoxycinnamate containing quercetin delayed the photodegradation of both components under ultraviolet A radiation. J. Biomed. Nanotechnol. 4, 80–89 (2008)

    CAS  Google Scholar 

  19. Pisani, E., Fattal, E., Paris, J., Ringard, C., Rosilio, V., Tsapis, N.: Surfactant dependent morphology of polymeric capsules of perfluorooctyl bromide: Influence of polymer adsorption at the dichloromethane–water interface. J. Colloid. Interface Sci. 326, 66–71 (2008)

    Article  CAS  Google Scholar 

  20. Fontana, M.C., Coradini, K., Guterres, S.S., Pohlmann, A.R., Beck, R.C.R.: Nanoencapsulation as a way to control the release and to increase the photostability of clobetasol propionate: influence of the nanostructured system. J. Biomed. Nanotechnol. 5, 254–263 (2009)

    Article  CAS  Google Scholar 

  21. Guterres, S.S., Jäger, A., Pohlmann, A.R.: Nanoparticles useful in photoprotective composition for preventing skin diseases e.g. aging, wrinkles, dryness, oxidation, burns, erythemas, dermatosis, melasma, skin spots, dermatitis and cancer, comprise oil and ultraviolet filter. BIOLAB SANUS FARM LTDA (BIOL-Non-standard) and UNIV FEDERAL DO RIO GRANDE DO SUL (UYRI-Non-standard). Patent Numbers: WO2010040194-A2; WO2010040194-A3 (2010)

    Google Scholar 

  22. Jiménez, M.M., Pelletier, J., Bobin, M.F., Martini, M.C.: Influence of encapsulation on the in vitro percutaneous absorption of octyl methoxycinnamate. Int. J. Pharm. 272, 45–55 (2004)

    Article  Google Scholar 

  23. Lertsutthiwong, P., Rojsitthisak, P., Nimmannit, U.: Preparation of turmeric oil-loaded chitosan-alginate biopolymeric nanocapsules. Mater. Sci. Eng. C Biomim. Mater. Sens. Syst. 29, 856–860 (2009)

    Article  CAS  Google Scholar 

  24. Terroso, T., Külkamp, I.C., Jornada, D.S., Pohlmann, A.R., Guterres, S.S.: Development of semi-solid cosmetic formulations containing coenzyme Q10-loaded nanocapsules. Lat. Am. J. Pharm. 28, 819–826 (2009)

    CAS  Google Scholar 

  25. Almeida, J.S., Jezur, L., Fontana, M.C., Paese, K., Silva, C.B., Pohlmann, A.R., Guterres, S.S., Beck, R.C.R.: Oil-based nanoparticles containing alternative vegetable oils (grape seed oil and almond kernel oil): preparation and characterization. Lat. Am. J. Pharm. 28, 165–172 (2009)

    CAS  Google Scholar 

  26. Müller, C.R., Schaffazick, S.R., Pohlmann, A.R., de Lucca Freitas, L., Pesce da Silveira, N., Dalla Costa, T., Guterres, S.S.: Spray-dried diclofenac-loaded poly(epsilon-caprolactone) nanocapsules and nanospheres. Preparation and physicochemical characterization. Pharmazie 56, 864–867 (2001)

    Google Scholar 

  27. Teixeira, Z., Zanchetta, B., Melo, B.A.G., Oliveira, L.L., Santana, M.H.A., Paredes-Gamero, E.J., Justo, G.Z., Nader, H.B., Guterres, S.S., Duran, N.: Retinyl palmitate flexible polymeric nanocapsules: characterization and permeation studies. Colloids Surf B Biointerfaces (2010) (in press), doi:10.1016/j.colsurfb.2010.06.016

    Google Scholar 

  28. Poletto, F.S., Jäger, E., Cruz, L., Pohlmann, A.R., Guterres, S.S.: The effect of polymeric wall on the permeability of drug-loaded nanocapsules. Mater. Sci. Eng. C Biomim. Mater. Sens. Syst. 28, 472–478 (2008)

    Article  CAS  Google Scholar 

  29. Romero-Cano, M.S., Vincent, B.: Controlled release of 4-nitroanisole from poly(lactic acid) nanoparticles. J. Control. Rel. 9, 127–135 (2002)

    Article  Google Scholar 

  30. Khoee, S., Yaghoobian, M.: An investigation into the role of surfactants in controlling particle size of polymeric nanocapsules containing penicillin-G in double emulsion. Eur. J. Med. Chem. 44, 2392–2399 (2009)

    Article  CAS  Google Scholar 

  31. Joo, H.H., Lee, H.Y., Guan, Y.S., Kim, J.C.: Colloidal stability and in vitro permeation study of poly(e-caprolactone) nanocapsules containing hinokitiol. J. Ind. Eng. Chem. 14, 608–613 (2008)

    CAS  Google Scholar 

  32. Cruz, L., Soares, L.U., Dalla Costa, T., Mezzalira, G., da Silveira, N.P., Guterres, S.S., Pohlmann, A.R.: Diffusion and mathematical modeling of release profiles from nanocarriers. Int. J. Pharm. 313, 198–205 (2006)

    Article  CAS  Google Scholar 

  33. Montasser, I., Briançon, S., Fessi, H.: The effect of monomers on the formulation of polymeric nanocapsules based on polyureas and polyamides. Int. J. Pharm. 335, 176–179 (2007)

    Article  CAS  Google Scholar 

  34. Fontana, M.C., Coradini, K., Pohlmann, A.R., Guterres, S.S., Beck, R.C.R.: Nanocapsules prepared from amorphous polyesters: effect on the physicochemical characteristics, drug release, and photostability. J. Nanosci. Nanotechnol. 10, 3091–3099 (2010)

    Article  CAS  Google Scholar 

  35. Santander-Ortega, M.J., Lozano-López, M.V., Bastos-González, D., Peula-García, J.M., Ortega-Vinuesa, J.L.: Novel core-shell lipid-chitosan and lipid-poloxamer nanocapsules: stability by hydration forces. Colloid. Polym. Sci. 288, 159–172 (2010)

    Article  CAS  Google Scholar 

  36. Wu, X., Landfester, K., Musyanovych, A., Guy, R.H.: Disposition of Charged Nanoparticles after Their Topical Application to the Skin. Skin Pharmacol. Physiol. 23, 117–123 (2010)

    Article  CAS  Google Scholar 

  37. Mosqueira, V.C.F., Legrand, P., Pinto-Alphandary, H., Puisieux, F., Barratt, G.: Poly(d,l-lactide) nanocapsules prepared by a solvent displacement process: Influence of the composition on physicochemical and structural properties. J. Pharm. Sci. 89, 614–626 (2000)

    Article  CAS  Google Scholar 

  38. Peracchia, M.T., Fattal, E., Desmaële, D., Besnard, M., Noël, J.P., Gomis, J.M., Appel, M., d’Angelo, J., Couvreur, P.: Stealth® PEGylated polycyanoacrylate nanoparticles for intravenous administration and splenic targeting. J. Control Release 60, 121–128 (1999)

    Article  CAS  Google Scholar 

  39. Wu, X., Griffin, P., Price, G.J., Guy, R.H.: Preparation and in vitro evaluation of topical formulations based on polystyrene-poly-2-hydroxyl methacrylate nanoparticles. Mol. Pharm. 6, 1449–1456 (2009)

    Article  CAS  Google Scholar 

  40. Jiménez, M.M., Pelletier, J., Bobin, M.F., Martini, M.C.: Influence of encapsulation on the in vitro percutaneous absorption of octyl methoxycinnamate. Int. J. Pharm. 272, 45–55 (2004)

    Article  Google Scholar 

  41. Olvera-Martinez, B.I., Cazares-Delgadillo, J., Calderilla-Faardo, S.B., Villalobos-Garcia, R., Ganem-Quintanar, A., Quintanar-Guerrero, D.: Preparation of polymeric nanocapsules containing octyl methoxycinnamate by the emulsification-diffusion technique: Penetration across the stratum corneum. J. Pharm. Sci. 94, 1552–1559 (2005)

    Article  CAS  Google Scholar 

  42. Marchiori, M.L., Lubini, G., Dalla Nora, G., Friedrich, R.B., Fontana, M.C., Ourique, A.F., Bastos, M.O., Rigo, L.A., Silva, C.B., Tedesco, S.B., Beck, R.C.R.: Hydrogel containing dexamethasone-loaded nanocapsules for cutaneous administration: preparation, characterization, and in vitro drug release study. Drug Dev. Ind. Pharm. 36, 962–971 (2010)

    Article  CAS  Google Scholar 

  43. Anton, N., Benoit, J.P., Saulnier, P.: Design and production of nanoparticles formulated from nanoemulsion templates - A review. J. Control Release 128, 185–199 (2008)

    Article  CAS  Google Scholar 

  44. Gallardo, M., Couarraze, G., Denizot, B., Treupel, L., Couvreur, P., Puisieux, F.: Study of the mechanisms of formation of nanoparticles and nanocapsules of polyisobutyl-2-cyanoacrylate. Int. J. Pharm. 100, 55–64 (1993)

    Article  CAS  Google Scholar 

  45. Soppimath, K.S., Aminabhavi, T.M., Kulkarni, A.R., Rudzinski, W.E.: Biodegradable polymeric nanoparticles as drug delivery devices. J. Control Release 70, 1–20 (2001)

    Article  CAS  Google Scholar 

  46. Wohlgemuth, M., Mächtle, W., Mayer, C.: Improved preparation and physical studies of polybutylcyanoacrylate nanocapsules. J. Microencapsul. 17, 437–448 (2000)

    Article  CAS  Google Scholar 

  47. Bouchemal, K., Briançon, S., Couenne, F., Fessi, H., Tayakout, M.: Stability studies on colloidal suspensions of polyurethane nanocapsules. J. Nanosci. Nanotechnol. 6, 3187–3192 (2006)

    Article  CAS  Google Scholar 

  48. Fessi, H., Puisieux, F., Devissague, J.P.: Nanocapsules prodn. by treating soln. of wall and core materials with non-solvent contg. surfactant. CNRS CENT NAT RECH SCI(CNRS-C) CNRS CENT NAT RECH(CNRS-C). Patent numbers: EP274961-B1; EP274961-A1; FR2608942-A1; EP274961-A; FR2608942-A; JP63232840-A; US5049322-A; CA1293170-C; EP274961-B; DE3777793-G; ES2031529-T3; JP94093998-B2 (1988)

    Google Scholar 

  49. Vitale, S.A., Katz, J.L.: Liquid droplet dispersions formed by homogeneous liquid–liquid nucleation: “The ouzo effect”. Langmuir. 19, 4105–4110 (2003)

    Article  CAS  Google Scholar 

  50. Ganachaud, F., Katz, J.L.: Nanoparticles and nanocapsules created using the Ouzo effect: Spontaneous emulsification as an alternative to ultrasonic and high-shear devices. Chemphyschem. 6, 209–216 (2005)

    Article  CAS  Google Scholar 

  51. Vauthier, C., Bouchemal, K.: Methods for the preparation and manufacture of polymeric nanoparticles. Pharm. Res. 26, 1025–1058 (2008)

    Article  Google Scholar 

  52. Quintanar-Guerrero, D., Fessi, H., Allemann, E., Doelker, E.: Influence of stabilizing agents and preparative variables on the formation of poly(d,l-lactic acid) nanoparticles by an emulsification-diffusion technique. Int. J. Pharm. 143, 133–141 (1996)

    Article  CAS  Google Scholar 

  53. Moinard-Checot, D., Chevalier, Y., Briançon, S., Beney, L., Fessi, H.: Mechanism of nanocapsules formation by the emulsion–diffusion process. J. Colloid Interface Sci. 317, 458–468 (2008)

    Article  CAS  Google Scholar 

  54. Choi, S.W., Kwon, H.Y., Kim, W.S., Kim, J.H.: Thermodynamic parameters on poly(d,l-lactide-coglycolide) particle size in emulsification-diffusion process. Colloids Surf A Physicochem. Eng. Asp. 201, 283–289 (2002)

    Article  CAS  Google Scholar 

  55. Poletto, F.S., Fiel, L.A., Donida, B., Re, M.I., Guterres, S.S., Pohlmann, A.R.: Controlling the size of poly(hydroxybutyrate-co-hydroxyvalerate) nanoparticles prepared by emulsification–diffusion technique using ethanol as surface agent. Colloids Surf A Physicochem. Eng. Asp. 324, 105–112 (2008)

    Article  CAS  Google Scholar 

  56. Galindo-Rodriguez, S., Allémann, E., Fessi, H., Doelker, E.: Physicochemical parameters associated with nanoparticle formation in the salting-out, emulsification-diffusion and nanoprecipitation methods. Pharm. Res. 21, 1428–1439 (2004)

    Article  CAS  Google Scholar 

  57. Lertsutthiwong, P., Noomun, K., Jongaroonngamsang, N., Rojsitthisak, P., Nimmannit, U.: Preparation of alginate nanocapsules containing turmeric oil. Carbohydr. Polym. 74, 209–214 (2008)

    Article  CAS  Google Scholar 

  58. Quintanar, D., Allémann, E., Doelker, E., Fessi, H.: Preparation and characterization of nanocapsules from preformed polymers by a new process based on emulsification–diffusion technique. Pharm. Res. 15, 1056–1062 (1998)

    Article  Google Scholar 

  59. Zambaux, M.F., Bonneaux, F., Gref, R., Maincent, P., Dellacherie, E., Alonso, M.J., Labrude, P., Vigneron, C.: Influence of experimental parameters on the characteristics of poly(lactic acid) nanoparticles prepared by a double emulsion method. J. Control Release 50, 31–40 (1998)

    Article  CAS  Google Scholar 

  60. Magenheim, B., Benita, S.: Nanoparticle characterization: a comprehensive physicochemical approach. STP Pharma. Sci. 1, 221–241 (1991)

    CAS  Google Scholar 

  61. Prasad, V., Semwogerere, D., Weeks, E.R.: Confocal microscopy of colloids. J. Phys. Condens. Matter 19, 113102–113127 (2007)

    Article  Google Scholar 

  62. Berne, B.J., Pecora, R.: Laser Light-Scattering from Liquids. Annu. Rev. Phys. Chem. 25, 233–253 (1974)

    Article  CAS  Google Scholar 

  63. Aragón, S.R., Pecora, R.: Theory of Dynamic Light-Scattering from Polydisperse Systems. J. Chem. Phys. 64, 2395–2404 (1976)

    Article  Google Scholar 

  64. Mengual, O., Meunier, G., Cayre, I., Puech, K., Snabre, P.: Characterisation of instability of concentrated dispersions by a new optical analyser: the TURBISCAN MA 1000. Colloids Surf A Physicochem. Eng. Asp. 152, 111–123 (1999)

    Article  CAS  Google Scholar 

  65. Lemarchand, C., Couvreur, P., Besnard, M., Costantini, D., Gref, R.: Novel polyester-polysaccharide nanoparticles. Pharm. Res. 20, 1284–1292 (2003)

    Article  CAS  Google Scholar 

  66. Poletto, F.S., Silveira, R.P., Fiel, L.A., Donida, B., Rizzi, Guterres, S.S., Pohlmann, A.R.: Size-Control of Poly(ε-caprolactone) nanospheres by the interface effect of ethanol on the primary emulsion droplets. J. Nanosci. Nanotechnol. 9, 4933–4941 (2009)

    Article  CAS  Google Scholar 

  67. Lboutounne, H., Chaulet, J.F., Ploton, C., Falson, F., Pirot, F.: Sustained ex vivo skin antiseptic activity of chlorhexidine in poly(ε-caprolactone) nanocapsule encapsulated form and as a digluconate. J. Control Release 82, 319–334 (2002)

    Article  CAS  Google Scholar 

  68. Paese, K., Jäger, A., Poletto, F.S., Fonseca Pinto, E., Rossi-Bergmann, B., Pohlmann, A.R., Guterres, S.S.: Semisolid formulation containing a nanoencapsulated sunscreen: effectiveness, in vitro photostability and immune response. J. Biomed. Nanotechnol. 5, 1–7 (2009)

    Article  Google Scholar 

  69. Milão, D., Knorst, M.T., Richter, W., Guterres, S.S.: Hydrophilic gel containing nanocapsules of diclofenac: Development, stability study and physico-chemical characterization. Pharmazie 58, 325–329 (2003)

    Google Scholar 

  70. Gaumet, M., Vargas, A., Gurny, R., Delie, F.: Nanoparticles for drug delivery: The need for precision in reporting particle size parameters. Eur. J. Pharm. Biopharm. 69, 1–9 (2008)

    Article  CAS  Google Scholar 

  71. Bernardy, N., Romio, A.P., Barcelos, E.I., Pizzol, C.D., Dora, C.L., Lemos-Senna, E., Araujo, P.H.H., Sayer, C.: Nanoencapsulation of Quercetin via Miniemulsion Polymerization. J. Biomed. Nanotechnol. 6, 181–186 (2010)

    Article  CAS  Google Scholar 

  72. Fresta, M., Cavallaro, G., Giammona, G., Wehrli, E., Puglisi, G.: Preparation and characterization of polyethyl-2-cyanoacrylate nanocapsules containing antiepileptic drugs. Biomaterials 17, 751–758 (1996)

    Article  CAS  Google Scholar 

  73. Beck, R.C.R., Pohlmann, A.R., Hoffmeister, C., Gallas, M.R., Collnot, E., Schaefer, U., Guterres, S.S., Lehr, C.M.: Hoffmeister c, Gallas MR, Collnot E, Schaefer U, Guterres SS, Lehr CM Dexamethasone-loaded nanoparticle-coated microparticles: Correlation between in vitro drug release and drug transport across Caco-2 cell monolayers. Eur. J. Pharm Biopharm. 67, 18–30 (2007)

    Article  CAS  Google Scholar 

  74. de Assis, D.N., Mosqueira, V.C.F., Vilela, J.M.C., Andrade, M.S., Cardoso, V.N.: Release profiles and morphological characterization by atomic force microscopy and photon correlation spectroscopy of (99 m) technetium–fluconazole nanocapsules. Int. J. Pharm. 349, 152–160 (2008)

    Article  Google Scholar 

  75. Alves, M.P., Scarrone, A.L., Santos, M., Pohlmann, A.R., Guterres, S.S.: Human skin penetration and distribution of nimesulide from hydrophilic gels containing nanocarriers. Int. J. Pharm. 341, 215–220 (2007)

    Article  CAS  Google Scholar 

  76. Delgado, A.V., Gonzalez-Caballero, E., Hunter, R.J., Koopal, L.K., Lyklema, J.: Measurement and interpretation of electrokinetic phenomena (IUPAC technical report). Pure Appl. Chem. 77, 1753–1805 (2005)

    Article  CAS  Google Scholar 

  77. Preetz, C., Rübe, A., Reiche, I., Hause, G., Mäder, K.: Preparation and characterization of biocompatible oil-loaded polyelectrolyte nanocapsules. Nanomedicine 4, 106–114 (2008)

    CAS  Google Scholar 

  78. Sussman, E.M., Clarke, M.B., Shastri, V.P.: Single-step process to produce surface-functionalized polymeric nanoparticles. Langmuir. 23, 12275–12279 (2007)

    Article  CAS  Google Scholar 

  79. Aboubakar, M., Puisieux, F., Couvreur, P., Deyme, M., Vauthier, C.: Study of the mechanism of insulin encapsulation in poly(isobutylcyanoacrylate) nanocapsules obtained by interfacial polymerization. J. Biomed. Mater Res. 47, 568–576 (1999)

    Article  CAS  Google Scholar 

  80. Lboutounne, H., Faivre, V., Falson, F., Pirot, F.: Characterization of transport of chlorhexidine-loaded nanocapsules through hairless and Wistar rat skin. Skin Pharmacol. Physiol. 17, 176–182 (2004)

    Article  CAS  Google Scholar 

  81. Sartori, T., Seigi Murakami, F., Pinheiro Cruz, A., Machado de Campos, A.: Development and validation of a fast RP-HPLC method for determination of methotrexate entrapment efficiency in polymeric nanocapsules. Journal of Chromatogr. Sci. 46, 505–509 (2008)

    CAS  Google Scholar 

  82. Fontana, M.C., Bastos, M.O., Beck, R.C.R.: Development and Validation of a Fast RP-HPLC Method for the Determination of Clobetasol Propionate in Topical Nanocapsule Suspensions. J. Chromatogr. Sci. 48, 637–640 (2010)

    CAS  Google Scholar 

  83. ICH. Validation of analytical procedures: text and methodology Q2(R1) (2005), http://www.ich.org/LOB/media/MEDIA417.pdf

  84. Schaffazick, S.R., Guterres, S.S., Pohlmann, A.R., Lucca Freitas, L.: Caracterização e estabilidade físico-química de sistemas poliméricos nanoparticulados para administração de fármacos. Quim Nova 26, 726–737 (2003)

    CAS  Google Scholar 

  85. Lopes, E.C., Pohlmann, A.R., Bassani, V.L., Guterres, S.S.: Polymeric colloidal systems containing ethionamide: Preparation and Physico-Chemical Characterization. Pharmazie 55, 527–530 (2000)

    CAS  Google Scholar 

  86. Alvarez-Roman, R., Barre, G., Guy, R.H., Fessi, H.: Biodegradable polymer nanocapsules containing a sunscreen agent: preparation and photoprotection. Eur. J. Pharm. Biopharm. 52, 191–195 (2001)

    Article  CAS  Google Scholar 

  87. Weiss-Angeli, V., Bourgeois, S., Pelletier, J., Guterres, S.S., Fessi, H., Bolzinger, M.A.: Development of an original method to study drug release from polymeric nanocapsules in the skin. J. Pharm. Pharmacol. 62, 35–45 (2010)

    Article  CAS  Google Scholar 

  88. Nhung, D.T.T., Freydiere, A.M., Constant, H., Falson, F., Pirot, F.: Sustained antibacterial effect of a hand rub gel incorporating chlorhexdine-loaded nanocapsules (Nanochlorex®). Int. J. Pharm. 334, 166–172 (2007)

    Article  CAS  Google Scholar 

  89. Alves, M.P., Pohlmann, A.R., Guterres, S.S.: Semisolid topical formulations containing nimesulide-loaded nanocapsules, nanospheres or nanoemulsion: development and rheological characterization. Pharmazie 60, 900–904 (2005)

    CAS  Google Scholar 

  90. Hwang, S.L., Kim, J.C.: In vivo hair growth promotion effects of cosmetic preparations containing hinokitiol-loaded poly(epsilon-caprolacton) nanocapsules. J. Microencapsul. 25, 351–356 (2010)

    Article  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Departamento de Química Orgânica, Universidade Federal do Rio Grande do Sul, Av. Bento Gonçalves, CP 15003, 91501-970, Porto Alegre, RS, Brazil

    Fernanda S. Poletto & Adriana R. Pohlmann

  2. Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Av. Ipiranga, 2752, 90610-000, Porto Alegre, RS, Brazil

    Ruy C. R. Beck & Sílvia S. Guterres

Authors
  1. Fernanda S. Poletto
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ruy C. R. Beck
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Sílvia S. Guterres
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Adriana R. Pohlmann
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Dept. de Produção e Controle de Medicame, Faculdade de Farmácia, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Brazil

    Ruy Beck

  2. Faculty of Pharmacy, Dept. de Produção e Controle de Medicame, Federal University of Rio Grande do Sul, Av. Ipiranga 2752, 90610-000, Porto Alegre, Brazil

    Silvia Guterres

  3. Institut of Chemistry, Departamento de Química Orgânica, Federal University of Rio Grande do Sul, Av. Bento Gonçalves 9500, 91501-970, Porto Alegre, Brazil

    Adriana Pohlmann

Rights and permissions

Reprints and permissions

Copyright information

© 2011 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Poletto, F.S., Beck, R.C.R., Guterres, S.S., Pohlmann, A.R. (2011). Polymeric Nanocapsules: Concepts and Applications. In: Beck, R., Guterres, S., Pohlmann, A. (eds) Nanocosmetics and Nanomedicines. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19792-5_3

Download citation

Publish with us

Policies and ethics

Search

Navigation