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Multiple Chemikaliensensitivität (MCS)

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Chronisches Müdigkeits- und Fibromyalgiesyndrom

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Zusammenfassung

Um das Jahr 1980 wurden an der damals neu eröffneten arbeitsmedizinischen Klinik der Yale University einzelne Patienten gesehen, die nach erhöhter beruflicher Gefahrstoffexposition zunächst mit einer temporären Symptomatik reagierten, die teils leichterer Art war, aber mit der Exposition in einen toxikologisch plausiblen Zusammenhang gebracht werden konnte. Nach diesem initialen Geschechen entwickelten die betroffenen Personen anscheinend eine besodere Empfindlichkeit gegenüber geringfügigen Schadstoffeinwirkungen [17]. Sowohl die verantwortlich gemachten anfänglichen Expositionen (Lösemittel, Pestizide, Atemwegsirritanzien), wie auch die spärteren, geringgradigen Trigger-Expositionen und die damit von den Betroffenen assoziierten Symptome ließen keine einheitlichen Muster erkennen. Die Untersucher interpretierten das Erkrankungsgeschehen seinerzeit als posttraumatische Belastungsstörung, d.h. auf der Grundlage eines psychosomatischen Konzeptes. Cullen [17] lieferte außerdem eine Bezeichnung, „multiple chemical sensitivities“ (MCS),sowie eine für Forschungszwecke bestimmte hypothetische FAlldefinition, die er in den folgenden Jahren etwas modifizierte [18]. Die Cullen’schen Definitionskriterien sind zusammen mit den von anderen Autoren empfohlenen Kriterien weiter unten aufgeführt.

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Literatur

  1. Aaron LA, Buchwald D (2001) A review of the evidence for overlap unexplained clinical conditions. Ann Intern Med 134:868–881 18.

    Google Scholar 

  2. Adamec R (1994) Modelling anxiety disorders following chemical exposures.Toxicol Ind Health 10:391–420

    CAS  Google Scholar 

  3. Aldenhoff J (1999) Zelluläre Grundlagen seelischer Stö- rungen. In: Heimchen H, Henn F, Lauter H, Sartorius N.(Hrsg) Grundlagen der Psychiatrie, Bd 1.Springer, Berlin Heidelberg New York, S 213–234

    Google Scholar 

  4. Antelman SM(1994) Time-dependent sensitization in animals:a possible model of multiple chemical sensitivity in humans.Toxicol Ind Health 10:335–342 20.

    PubMed  Google Scholar 

  5. Bascom R (1992) Multiple chemical sensitivity: a respiratory disorder? Toxicol Ind Health 8:221–228

    PubMed  CAS  Google Scholar 

  6. Bascom R, Meggs WJ, Frampton Metal.(1997) Neurogenic inflammation: With additional discussion of central and 21. perceptual integration of nonneurogenic inflammation. Environ Health Persp 105 [Suppl 21:531–537

    Google Scholar 

  7. Bell IR (1982) Clinical ecology:a new medical approach to 22. environmental illness. Common Knowledge, Bolinas/CA

    Google Scholar 

  8. Bell IR (1992) Neuropsychatric and biosocial mechanisms 23. in multiple chemical sensitivity: an olfactory-limbic model. In: NRC — National Research Council (ed) Multiple chemical sensitivities. National Academy Press, Washing- 24. ton DC, pp 89–108

    Google Scholar 

  9. Bell IR (1994) White paper: neuropsychiatric aspects of 25. sensitivity to low-level chemicals: a neural sensitization model.Toxicol Ind Health 10(4/5):277–312

    CAS  Google Scholar 

  10. Bell IR, Miller CS, Schwartz GE (1992) An olfactory-limbic model of multiple chemical sensitivity syndrome: Possi- 26. ble relationships to kindling and affective spectrum disorders. Biol Psychiatry 32:218–242

    Article  PubMed  CAS  Google Scholar 

  11. Bell IR., Schwartz GE, Amend D, Peterson JM, Stini WA (1994) Sensitization to early life stress and response to 27. chemical odors in older adults. Biol Psychiatry 35:857–863

    Article  PubMed  CAS  Google Scholar 

  12. Bell IR, Miller CS, Schwartz GE, Peterson JM, Amend D (1996) Neuropsychiatric and somatic characteristics of young adults with and without self-reported chemical 28. odor intolerance and chemical sensitivity. Arch Environ Health 51:9–21

    Article  PubMed  CAS  Google Scholar 

  13. Bell IR, Rossi J Ill, Gilbert ME et al. (1997)Testing the neural 29. sensitization and kindling hypothesis for illness from low levels of environmental chemicals. Environ Health Persp 105 [Suppl 2]:539–547 30.

    Google Scholar 

  14. Bell IR, Baldwin CM, Fernandez M, Schwartz GER (1999) Neural sensitization model for multiple chemical sensitivity: overview of theory and empirical evidence. Toxicol Ind Health 15:295–304 31.

    PubMed  CAS  Google Scholar 

  15. Buchwald D., Garrity D (1994) Comparison of patients with chronic fatigue syndrome, fibromyalgia, and multi-ple chemical sensitivities. Arch Intern Med 154: 2049–32. 2053

    Google Scholar 

  16. Csef H (1999) Gemeinsamkeiten von Chronic Fatigue Syn- 33. drom, Fibromyalgie and multipler chemischer Sensitivität. Dtsch Med Wochenschr 124:163–169

    PubMed  CAS  Google Scholar 

  17. Cullen MR (1987) The worker with chemical sensitivities: an overview. In: Cullen MR (ed) Workers with multiple chemical sensitivities. occupational medicine: state of the art reviews, vol 2, no 4. Hanley & Belfus, Philadelphia, pp 655–661

    Google Scholar 

  18. Cullen MR (1994) Low-level environmental exposures. In: Rosenstock L, Cullen MR (eds) Textbook of clinical occupational and environmental medicine. Saunders, Philadelphia, pp 667–672

    Google Scholar 

  19. Davidoff AL, Keyl PM (1996) Symptoms and health status in individuals with multiple chemical sensitivities syndrome from four reported sensitizing exposures and a general population comparison group. Arch Environ Health 51:201–213

    Article  PubMed  CAS  Google Scholar 

  20. Doty RL, Deems DA, Frye RE, Pelberg R, Shapiro A (1988) Olfactory sensitivity, nasal resistance, and autonomic function in patients with multiple chemical sensitivities. Arch Otolaryngol Head Neck Surg 114:1422–1427

    Article  PubMed  CAS  Google Scholar 

  21. Eis D (1998/99) Clinical Ecology — an unproved approach in the context of environmental medicine. Zentralbl Hyg Umweltmed 202:291–330

    Google Scholar 

  22. Eis D (1999) Epidemiologie der „multiplen chemischen Sensitivität“ (MCS). Allergologie 22:538–554

    Google Scholar 

  23. Fiedler N, Kipen H (1997) Chemical Sensitivity:The Scientific Literature. Environ Health Persp 105(Suppl 2): 409–415

    Article  Google Scholar 

  24. Fiedler N, Maccia C, Kipen HM (1992) Evaluation of chemically sensitive patients.) Occup Med 34:529–538

    CAS  Google Scholar 

  25. Fiedler N, Kipen HM, DeLuca J, Kelly-McNeil K, Natelson B (1996) A controlled comparison of multiple chemical sensitivities and chronic fatigue syndrome. Psychosom Med 58:38–49

    PubMed  CAS  Google Scholar 

  26. Heuser G, Wojdani A, Heuser S (1992) Diagnostic markers of multiple chemical sensitivity. In: NRC — National Research Council (ed) Multiple chemical sensitivities. National Academy Press, Washington DC, pp 117–138

    Google Scholar 

  27. Hummel T, Roscher S, Jaumann M, Kobal G (1996) Intranasal chemoreception in patients with multiple chemical sensitivities: a double-blind investigation. Regul Toxicol Pharmacol 24:79–86

    Article  Google Scholar 

  28. Kipen H, Fiedler N, Maccia C et al. (1992) Immunological evaluation of chemically sensitive patients. Toxicol Ind Health 8:125–135

    PubMed  CAS  Google Scholar 

  29. Kreutzer R, Neutra RR, Lashuay N (1999) Prevalence of people reporting to chemicals in a population-based survey. Am J Epidemiol 150:1–12

    Article  PubMed  CAS  Google Scholar 

  30. IPCS — International Programme on Chemical Safety (1996) Report of the workshop on Multiple Chemical Sensitivities (MCS) (Berlin, Germany, 21–23 February 1996). ICPS/WHO,Geneva

    Google Scholar 

  31. Letznoff A (1997a) Provocative challenges in patients with multiple chemical sensitivity..? Allergy Clin Immunol 99:439–442

    Google Scholar 

  32. Letznoff A (1997b) Reply [letter]. J Allergy Clin Immunol 100:856

    Article  Google Scholar 

  33. Maibach H, Naranch K, Repka R et al. (2001) Multiple chemical sensitivity in chronic fatigue syndrome (CFS). J Allergy clin Immunol 107(2)Abstract-No.91

    Google Scholar 

  34. McGovern JJ, Lazaroni JA, Hicks MF, Adler JC, Cleary P (1983) Food and chemical sensitivities:clinical and immunologic correlates.Arch Otolaryngol 109:292–297

    Article  PubMed  Google Scholar 

  35. Meggs WJ (1992) Immunological mechanisms of disease and the multiple chemical sensitivity syndrome. In: NRC — National Research Council (ed) Multiple chemical sensitivities.National Academy Press,Washington DC,pp 155–168

    Google Scholar 

  36. MeggsWJ (1995) Neurogenic switching:A hypothesis for a mechanism for shifting the site of inflammation in allergy and chemical sensitivity. Environ Health Persp 103:54–56

    Article  Google Scholar 

  37. Meggs WJ (1997) Hypothesis for induction and propagation of chemical sensitivity based on biopsy studies. Environ Health Persp 105 [Suppl 2]:473–478

    CAS  Google Scholar 

  38. Meggs WJ, Cleveland CH Jr (1993) Rhinolaryngoscopic examination of patients with the multiple chemical sensitivity syndrome. Arch Environ Health 48:14–18

    Article  PubMed  CAS  Google Scholar 

  39. Meggs WJ, Dunn KA, Bloch RM, Goodman PE, Davidoff AL (1996) Prevalence and nature of allergy and chemical sensitivity in a general population. Arch Environ Health 51: 275–281

    Article  PubMed  CAS  Google Scholar 

  40. Miller CS (1992) Possible models for multiple chemical sensitivity: Conceptual issues and role of the limbic system.Toxicol Ind Health 8:181–202

    CAS  Google Scholar 

  41. Millqvist E, Bende M, Löwhagen O (1998) Sensory hyper-reactivity — a possible mechanism underlying cough and asthma-like symptoms.Allergy 53:1208–1212

    CAS  Google Scholar 

  42. Millqvist E, Bengtsson U, Löwhagen 0 (1999) Provocation with perfume in the eyes induce airway symptoms in patients with sensory hyperreactivity.Allergy 54:495–499

    CAS  Google Scholar 

  43. Mitchell CS, Donnay A,Hoover DR, Margolick JB (2000) Immunologic parameters of multiple chemical sensitivity. Occup Med 15/3:647–665

    CAS  Google Scholar 

  44. NRC — National Research Council (1992) Multiple chemical sensitivities:addendum to biologic markers in immunotoxicology. National Academy Press,Washington DC

    Google Scholar 

  45. NethercottiR,DavidoffLL,CurbowB,AbbeyH(1993)Multiple chemical sensitivities syndrome: toward a working case definition.Arch Environ Health 48:19–26

    Article  Google Scholar 

  46. Rea WJ, Bell IR, Suits CW, Smiley RE (1978) Food and chemical susceptibility after environmental chemical overexposure:Case histories.Ann Allergy 41:101–110

    CAS  Google Scholar 

  47. Rea WJ, Johnson AR, Youdim S, Fenyves EJ, Samadi N (1986) T & B lymphocyte parameters measures in chemically sensitive patients and controls.Clin Ecol 4:11–14

    Google Scholar 

  48. Rea WJ, Ross GH, Johnson AR et al. (1990) Confirmation of chemical sensitivity by means of double-blind inhalant challenge of toxic volatile chemicals.Clin Ecol 6:113–118

    Google Scholar 

  49. Reid S,Hotopf M, Hull Letal.(2001) Multiple chemical sensitivity and chronic fatigue syndrome in british gulf war veterans.Am J Epidemiol 153:604–609

    Google Scholar 

  50. Ring J, Gabriel G, Vieluf D, Przybilla B (1991) „Klinisches Ökologie-Syndrom“ („Öko-Syndrom”). Münch Med Wochenschr 133:50–55

    Google Scholar 

  51. Ross PM, Whysner J, Covello VT et al. (1999) Olfaction and symptoms in the multiple chemical sensitivities syndrome. Prey Med 28:467–480

    Article  CAS  Google Scholar 

  52. Schottenfeld RS, Cullen M (1985) Occupational-induced post traumatic stress disorders. Am J Psychiatry 142: 198–202

    PubMed  CAS  Google Scholar 

  53. Shusterman D, Balmers J,Cone J (1988) Behavioral sensitization to irritants/odorants after acute overexposures. J Occup Med 30:565–567

    CAS  Google Scholar 

  54. Simon GE, Daniell W, Stockbridge H, Claypoole K, Rosenstock L (1993) Immunologic, psychological, and neuropsychological factors in multiple chemical sensitivity: a controlled study.Ann Intern Med 19:97–103

    Google Scholar 

  55. Sorg BA, Prasad BM (1997) Potential role of stress and sensitization in the development and expression of multiple chemical sensitivity. Environmental Health Perspectives 105(suppl 2):467–471

    Article  PubMed  CAS  Google Scholar 

  56. Sorg BA, Hooks MS, Kalivas PW (1994) Neuroanatomy and neurochemical mechanisms of time-dependent sensitization.Toxicol Ind Health 10:369–386

    CAS  Google Scholar 

  57. Sorg BA, Willis JR, See RE, Hopkins B,Westberg HH (1998) Repeated low-level formaldehyde exposure produces cross-sesitization to cocaine: Possible relevance to chemical sensitivity in humans. Neuropsychopharmacology 18: 385–394

    CAS  Google Scholar 

  58. Sparks Pi, Daniell W,Black DW et al.(1994) Multiple chemical sensitivity syndrome: a clinical perspective. I. Case definition, theories of pathogenesis, and research needs. J Occup Med 36:718–730

    Google Scholar 

  59. Staudenmayer H, Seiner JC, Buhr MP (1993) Double-blind provocation chamber challenges in 20 patients presenting with ?multiple chemical sensitivity? Regul Toxicol Pharmacol 18:44–53

    Article  PubMed  CAS  Google Scholar 

  60. Terr AL (1986) Environmental Illness: a critical review of 50 cases.Arch Intern Med 146:145–149

    CAS  Google Scholar 

  61. Weiss SRB, Post RM (1994) Caveats in the use of the kindling model of affective disorders. Toxicol Ind Health 10: 421–447

    PubMed  CAS  Google Scholar 

  62. Ziem G, McTamney J (1997) Profile of patients with chemical injury and sensitivity. Environ Health Persp 105 [Suppl 21:417–436

    Google Scholar 

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Authors
  1. Dieter Eis
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  1. Medizinische Klinik und Poliklinik Abteilung Innere Medizin, Universität Tübingen, Otfried-Müller-Straße 10, Tübingen, 72076, Deutschland

    Peter A. Berg

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Eis, D. (2003). Multiple Chemikaliensensitivität (MCS). In: Berg, P.A. (eds) Chronisches Müdigkeits- und Fibromyalgiesyndrom. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-19026-1_6

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  • DOI: https://doi.org/10.1007/978-3-642-19026-1_6

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-44194-6

  • Online ISBN: 978-3-642-19026-1

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