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Pathogenesis of Breast Cancer

  • Chapter
Molecular Basis of Breast Cancer

Abstract

It is not known when in the lifetime of a woman the initiation of breast cancer takes place, or whether a specific agent causes it. The fact that late menarche and a full-term pregnancy completed before age 24, or early full-term pregnancy, reduces the risk of breast cancer development, whereas early menarche, nulliparity and exposure to ionizing radiations at ages younger than 19 are associated with a higher breast cancer incidence [1, 2], indicates that the period encompassed between menarche and first fullterm pregnancy represents a window of high susceptibility for the initiation of breast cancer.

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  1. Breast Cancer Research Laboratory, Fox Chase Cancer Center, 333 Cottman Avenue, Philadelphia, PA, 19111, USA

    Jose Russo MD, FACP & Irma H. Russo MD, FACP

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Russo, J., Russo, I.H. (2004). Pathogenesis of Breast Cancer. In: Molecular Basis of Breast Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-18736-0_5

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