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Mhp1, the Na+-Hydantoin Membrane Transport Protein

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Encyclopedia of Biophysics

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References

  • Abramson J, Wright EM. Structure and function of Na+-symporters with inverted repeats. Curr Opin Struct Biol. 2009;19:425–32.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Adelman JL, Dale AL, Zwier MC, Bhatt D, Chong LT, Zuckerman DM, Grabe M. Simulations of the alternating access mechanism of the sodium symporter Mhp1. Biophys J. 2011;101:2399–407.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Boudker O, Verdon G. Structural perspectives on secondary active transporters. Trends Pharmacol Sci. 2010;31:418–26.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Faham S, Watanabe A, Besserer GM, Cascio D, Specht A, Hirayama BA, Wright EM, Abramson J. The crystal structure of a sodium galactose transporter reveals mechanistic insights into Na+-sugar symport. Science. 2008;321:810–4.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Forrest LR, Rudnick G. The rocking bundle: a mechanism for ion-coupled solute flux by symmetrical transporters. Physiology. 2009;24:377–86.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Forrest LR, Kraemer R, Ziegler C. The structural basis of secondary active transport mechanisms. Biochim Biophys Acta. 2011;1807:167–88.

    CAS  PubMed  Google Scholar 

  • Jardetzky O. Simple allosteric model for membrane pumps. Nature. 1966;211:969–70.

    CAS  PubMed  Google Scholar 

  • Javier Las Heras-Vázquez F, Clemente-JimĂ©nez JM, MartĂ­nez-RodrĂ­guez S, RodrĂ­guez-Vico F. Hydantoin racemase: the key enzyme for the production of optically pure α-amino acids, Ch 12. In: Fessner W-D, Anthonsen T, editors. Modern biocatalysis: stereoselective and environmentally friendly reactions. Weinheim: Wiley-VCH; 2009.

    Google Scholar 

  • Krishnamurthy H, Gouaux E. X-ray structures of LeuT in substrate-free outward-open and apo inward-open states. Nature. 2012;481(7382):469–74.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Krishnamurthy H, Piscitelli CL, Gouaux E. Unlocking the molecular secrets of sodium-coupled transporters. Nature. 2009;459:347–55.

    CAS  PubMed  Google Scholar 

  • Ren Q, Paulsen IT. Transport DB. 2010. http://www.membranetransport.org/. Accessed 1 May 2012.

  • Saier MH, Tran CV, Barabote RD. TCDB: the transporter classification database for membrane transport protein analyses and information. Nucleic Acids Res. 2006;34(Database issue):D181–6.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Saier Jr MH, Yen MR, Noto K, Tamang DG, Elkan C. The transporter classification database: recent advances. Nucleic Acids Res. 2009;37:D274–8.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Shimamura T, Yajima S, O’Reilly J, Rutherford NG, Henderson PJF, Iwata S. Crystallization of the hydantoin transporter Mhp1 from Microbacterium liquefaciens. Acta Crystallog. 2008;F64:1172–4.

    Google Scholar 

  • Shimamura T, Weyand S, Beckstein O, Rutherford NG, Hadden JM, Sharples D, Sansom MPS, Iwata S, Henderson PJF, Cameron AD. Molecular basis of alternating access membrane transport by the sodium-hydantoin transporter, Mhp1. Science. 2010;328:470–3.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Suzuki S, Henderson PJF. The hydantoin transport protein from Microbacterium liquefaciens. J Bacteriol. 2006;188:3329–36.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Suzuki S, Takenaka Y, Onishi N, Yokozeki K. Molecular cloning and expression of the hyu genes of Microbacterium liquefaciens responsible for the conversion of 5-substituted hydantoins to alpha amino acids, in Escherichia coli. Biosci Biotechnol Biochem. 2005;69:1473–82.

    CAS  PubMed  Google Scholar 

  • Watanabe A, Choe S, Chaptal V, Rosenberg JM, Wright EM, Grabe M, Abramson J. The Mechanism of sodium and substrate release from the binding pocket of vSGLT. Nature. 2010;468:988–91.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Weyand S, Shimamura T, Yajima S, Suzuki S, Mirza O, Krusong K, Carpenter EP, Rutherford NG, Hadden JM, O’Reilly J, Ma P, Saidijam M, Patching SG, Hope RJ, Norbertczak HT, Roach PCJ, Iwata S, Henderson PJF, Cameron AD. Molecular basis of the alternating access model of membrane transport: structure of a nucleobase-cation-symport-1 family transporter. Science. 2008;322:709–13.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Weyand S, Ma P, Beckstein O, Baldwin J, Jackson S, Suzuki S, Shimamura T, Sansom MSP, Iwata S, Cameron AD, Baldwin SA, Henderson PJF. The nucleobase-cation-symport-1 family of membrane transport proteins. In: Messerschmidt A, editor. Handbook of metalloproteins. Chichester: Wiley; 2010. p. 848–64.

    Google Scholar 

  • Weyand S, Shimamura T, Beckstein O, Sansom MPS, Iwata S, Henderson PJF, Cameron AD. The alternating access mechanism of transport as observed in the sodium-hydantoin transporter Mhp1. J Synchrotron Radiat. 2011;18:20–3.

    CAS  PubMed  Google Scholar 

  • Yamashita A, Singh SK, Kawate T, Jin Y, Gouaux E. Crystal structure of a bacterial homologue of Na+/Cl–-dependent neurotransmitter transporters. Nature. 2005;437:215–23.

    CAS  PubMed  Google Scholar 

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Authors and Affiliations

  1. Astbury Centre for Structural Molecular Biology, Institute of Membrane and Systems Biology, University of Leeds, Astbury 6.108b, Leeds, LS2 9JT, UK

    Scott M. Jackson, Simon G. Patching, Ekaterina Ivanova, Katie Simmons, David J. Sharples, Stephen A. Baldwin & Peter J. F. Henderson

  2. Membrane Protein Laboratory, Diamond Light Source, Harwell Science and Innovation Campus, Chilton, Didcot, Oxfordshire, OX11 0DE, UK

    Simone Weyand, Tatsuro Shimamura, Florian Brueckner, So Iwata & Alexander D. Cameron

  3. Division of Molecular Biosciences, Membrane Protein Crystallography Group, Imperial College, London, SW7 2AZ, UK

    Simone Weyand, Tatsuro Shimamura, Florian Brueckner, So Iwata & Alexander D. Cameron

  4. Ajinomoto Co. Inc., Kawasaki-ku, Kawasaki, Kanagawa, 2108681, Japan

    Shun’ichi Suzuki

  5. Structural Bioinformatics and Computational Biochemistry Unit, Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX13 QU, UK

    Mark P. S. Sansom & Oliver Beckstein

  6. Department of Physics, Arizona State University, Tempe, AZ, 85287-1504, USA

    Oliver Beckstein

Authors
  1. Scott M. Jackson
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  2. Simon G. Patching
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  3. Ekaterina Ivanova
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  4. Katie Simmons
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  5. Simone Weyand
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  6. Tatsuro Shimamura
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  7. Florian Brueckner
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  8. Shun’ichi Suzuki
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  9. So Iwata
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  10. David J. Sharples
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  11. Stephen A. Baldwin
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  12. Mark P. S. Sansom
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  13. Oliver Beckstein
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  14. Alexander D. Cameron
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  15. Peter J. F. Henderson
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Corresponding author

Correspondence to Peter J. F. Henderson .

Editor information

Editors and Affiliations

  1. Department of Biochemistry, University of Leicester, Leicester, UK

    Gordon C. K. Roberts

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© 2013 European Biophysical Societies' Association (EBSA)

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Jackson, S.M. et al. (2013). Mhp1, the Na+-Hydantoin Membrane Transport Protein. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_670

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