Skip to main content

Machinery of DNA Replication

  • Reference work entry
Book cover Encyclopedia of Biophysics

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 1,099.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Bailey S, Eliason WK, Steitz TA. Structure of hexameric DnaB helicase and its complex with a domain of DnaG primase. Science. 2007;318:459–63.

    CAS  PubMed  Google Scholar 

  • Bailey S, Wing RA, Steitz TA. The structure of T. aquaticus DNA polymerase III is distinct from eukaryotic replicative DNA polymerases. Cell. 2006;126:893–904.

    CAS  PubMed  Google Scholar 

  • Biswas EE, Biswas SB. Mechanism of DnaB helicase of Escherichia coli: structural domains involved in ATP hydrolysis, DNA binding, and oligomerization. Biochemistry. 1999;38:10919–928.

    CAS  PubMed  Google Scholar 

  • Brewster AS, Chen XS. Insights into the MCM functional mechanism: lessons learned from the archaeal MCM complex. Crit Rev Biochem Mol Biol. 2010;45:243–56.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Chang P, Marians KJ. Identification of a region of Escherichia coli DnaB required for functional interaction with DnaG at the replication fork. J Biol Chem. 2000;275:26187–195.

    CAS  PubMed  Google Scholar 

  • Chastain PD 2nd, Makhov AM, Nossal NG, Griffith JD. Analysis of the Okaaki fragment distributions along single long DNAs replicated by the bacteriophage & 4 proteins. Mol Cell. 2000;6:803–14.

    CAS  PubMed  Google Scholar 

  • Doublie S, Tabor S, Long AM, Richardson CC, Ellenberger T. Crystal structure of a bacteriophage T7 DNA replication complex at 2.2 A resolution. Nature. 1998;391:251–8.

    CAS  PubMed  Google Scholar 

  • Dua R, Levy DL, Li CM, Snow PM, Campbell JL. In vivo reconstitution of Saccharomyces cerevisiae DNA polymerase epsilon in insect cells. Purification and characterization. J Biol Chem. 2002;277:7889–96.

    CAS  PubMed  Google Scholar 

  • Gambus A, van Deursen F, Polychronopoulos D, Foltman M, Jones RC, Edmondson RD, Calzada A, Labib K. A key role for Ctf4 in coupling the MCM2-7 helicase to DNA polymerase alpha within the eukaryotic replisome. EMBO J. 2009;28:2992–3004.

    CAS  PubMed  Google Scholar 

  • Georgescu RE, Kurth I, Yao NY, Stewart J, Yurieva O, O'Donnell M. Mechanism of polymerase collision release from sliding clamps on the lagging strand. EMBO J. 2009;28:2981–91.

    CAS  PubMed  Google Scholar 

  • Gomez-Llorente Y, Fletcher RJ, Chen XS, Carazo JM, San Martin C. Polymorphism and double hexamer structure in the archaeal minichromosome maintenance (MCM) helicase from Methanobacterium thermoautotrophicum. J Biol Chem. 2005;280:40909–15.

    CAS  PubMed  Google Scholar 

  • Johansson E, MacNeill SA. The eukaryotic DNA polymerases take shape. Trends Biochem Sci. 2010;35:339–47.

    CAS  PubMed  Google Scholar 

  • Kong XP, Onrust R, O'Donnell M, Kuriyan J. Three-dimensional structure of the beta subunit of E. coli DNA polymerase III holoenzyme: a sliding DNA clamp. Cell. 1992;69:425–37.

    CAS  PubMed  Google Scholar 

  • Kornberg A, Baker TA. DNA replication. 2nd ed. New York: W.H. Freeman; 1992.

    Google Scholar 

  • Lamers MH, Georgescu RE, Lee SG, O'Donnell M, Kuriyan J. Crystal structure of the catalytic alpha subunit of E. coli replicative DNA polymerase III. Cell. 2006;126:881–92.

    CAS  PubMed  Google Scholar 

  • Langston LD, O'Donnell M. DNA polymerase delta is highly processive with proliferating cell nuclear antigen and undergoes collision release upon completing DNA. J Biol Chem. 2008;283:29522–531.

    CAS  PubMed  Google Scholar 

  • Masai H, Matsumoto S, You Z, Yoshizawa-Sugata N, Oda M. Eukaryotic chromosome DNA replication: where, when, and how? Annu Rev Biochem. 2010;79:89–130.

    CAS  PubMed  Google Scholar 

  • McInerney P, Johnson A, Katz F, O'Donnell M. Characterization of a triple DNA polymerase replisome. Mol Cell. 2007;27:527–38.

    CAS  PubMed  Google Scholar 

  • Nick McElhinny SA, Gordenin DA, Stith CM, Burgers PM, Kunkel TA. Division of labor at the eukaryotic replication fork. Mol Cell. 2008;30:137–144.

    CAS  PubMed Central  PubMed  Google Scholar 

  • O'Donnell M, Kuriyan J. Clamp loaders and replication initiation. Curr Opin Struct Biol. 2006;16:35–41.

    PubMed  Google Scholar 

  • Park K, Debyser Z, Tabor S, Richardson CC, Griffith JD. Formation of a DNA loop at the replication fork generated by bacteriophage T7 replication proteins. J Biol Chem. 1998;273:5260–70.

    CAS  PubMed  Google Scholar 

  • Pomerantz RT, O'Donnell M. What happens when replication and transcription complexes collide? Cell Cycle. 2010;9: 2537–43.

    CAS  PubMed  Google Scholar 

  • Remus D, Beuron F, Tolun G, Griffith JD, Morris EP, Diffley JF. Concerted loading of Mcm2-7 double hexamers around DNA during DNA replication origin licensing. Cell. 2009;139:719–30.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Reyes-Lamothe R, Sherratt DJ, Leake MC. Stoichiometry and architecture of active DNA replication machinery in Escherichia coli. Science. 2010;328:498.

    CAS  PubMed Central  PubMed  Google Scholar 

  • Steitz TA. A mechanism for all polymerases. Nature. 1998;391:231–2.

    CAS  PubMed  Google Scholar 

  • Van Oijen AM, Loparo JJ. Single-molecule studies of the replisome. Annu Rev Biophys. 2010;39:429–48.

    PubMed  Google Scholar 

  • Yao NY, Georgescu RE, Finkelstein J, O'Donnell ME. Single-molecule analysis reveals that the lagging strand increases replisome processivity but slows replication fork progression. Proc Natl Acad Sci USA. 2009;106:13236–41.

    CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Michael E. O’Donnell .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2013 European Biophysical Societies' Association (EBSA)

About this entry

Cite this entry

O’Donnell, M.E., Kurth, I. (2013). Machinery of DNA Replication. In: Roberts, G.C.K. (eds) Encyclopedia of Biophysics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16712-6_435

Download citation

Publish with us

Policies and ethics