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Long Non-Coding RNAs pp 95–118Cite as

Transcription of Satellite DNAs in Mammals

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Part of the book series: Progress in Molecular and Subcellular Biology ((PMSB,volume 51))

Abstract

Centromeric and pericentric regions have long been regarded as transcriptionally inert portions of chromosomes. A number of studies in the past 10 years disproved this dogma and provided convincing evidence that centromeric and pericentric sequences are transcriptionally active in several biological contexts.

In this chapter, we provide a comprehensive picture of the various contexts (cell growth and differentiation, stress, effect of chromatin organization) in which these sequences are expressed in mouse and human cells and discuss the possible functional implications of centromeric and pericentric sequences activation and/or of the resulting noncoding RNAs. Moreover, we provide an overview of the molecular mechanisms underlying the activation of centromeric and pericentromeric sequences as well as the structural features of encoded RNAs.

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Acknowledgments

Work in the team of Claire Vourc’h is supported by grants from by ARC (#5113) and by ANR (PCV08_324703). G. Biamonti is supported by grants from AIRC, Cariplo Foundation, and from European Union (EURASNET) Network of Excellence on Alternative Splicing (EURASNET).

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Authors and Affiliations

  1. INSERM U823; Institut Albert Bonniot, Université Joseph Fourier-Grenoble, La Tronche BP170, 38042, Grenoble cedex 9, France

    Claire Vourc’h

  2. Istituto di Genetica Molecolare CNR, Via Abbiategrasso 207, 27100, Pavia, Italy

    Giuseppe Biamonti

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  1. Claire Vourc’h
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  2. Giuseppe Biamonti
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Correspondence to Giuseppe Biamonti .

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  1. Center for Marine Research, Ruder Boskovic Institute, Bijenicka 54, Zagreb, 10001, Croatia

    Durdica Ugarkovic

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Vourc’h, C., Biamonti, G. (2011). Transcription of Satellite DNAs in Mammals. In: Ugarkovic, D. (eds) Long Non-Coding RNAs. Progress in Molecular and Subcellular Biology(), vol 51. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16502-3_5

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