Definition
Domain named after the three proteins PSD-95, Dlg, and ZO-1. It is a modular protein interaction domain that often occurs in scaffolding proteins that bind in a sequence-specific fashion to the C-terminal peptide sequence or at times the internal protein sequences of target proteins. These domains of approximately 90 amino acids are known by an acronym of the first three PDZ-containing proteins identified including the postsynaptic protein PSD-95/SAP90, the Drosophila septate junction protein Discs-large, and tight junction protein ZO-1. In addition to their interaction with membrane proteins and receptors, the PDZ domain-containing proteins also interact with F-actin cytoskeleton through ezrin–radixin–moesin (ERM) proteins.
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© 2011 Springer-Verlag Berlin Heidelberg
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(2011). PDZ Domain. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_4428
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DOI: https://doi.org/10.1007/978-3-642-16483-5_4428
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
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