Definition
Bisphosphonates are potent inhibitors of bone resorption and are widely used drugs for the treatment of osteoporosis, osteolytic bone metastasis, and tumor-associated hypercalcemia. These compounds have high affinity for calcium ions and therefore target bone mineral, where they are internalized by bone-resorbing osteoclasts and inhibit osteoclast function. Minodronate, a nitrogen-containing bisphosphonate, acts intracellularly by inhibiting farnesyl pyrophosphate synthase, thus leading to the inhibition of posttranslational prenylation of small molecular weight G proteins, which could also contribute to its anti-resorptive activity on osteoclasts and its antitumor effects in vivo.
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Minodronate is...
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References
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© 2011 Springer-Verlag Berlin Heidelberg
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Yamagishi, Si. (2011). Minodronate. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-16483-5_3757
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DOI: https://doi.org/10.1007/978-3-642-16483-5_3757
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Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-16482-8
Online ISBN: 978-3-642-16483-5
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