Skip to main content
SpringerLink
Log in

Therapie mit Immunglobulinen

  • Chapter
Transfusionsmedizin und Immunhämatologie

  • 6664 Accesses

Zusammenfassung

Immunglobuline (Antikörper) sind die Träger der spezifischen humoralen Immunität. Ihr vollständiges oder teilweises Fehlen kann zu Antikörpermangelsyndromen, Infektionskrankheiten und anderen Störungen der Immunantwort führen. Durch die Möglichkeit, Immunglobulinpräparate verschiedener Spezifität und Antikörperzusammensetzung aus menschlichem Spenderplasma zu gewinnen und diese in ausreichenden Mengen i. v. zu verabreichen, haben sich neue Therapieformen für einige Infektionserkrankungen und Antikörpermangelsyndrome eröffnet. Die Entdeckung der immunmodulatorischen Eigenschaften von Immunglobulinen ist die Grundlage für ihren Einsatz bei verschiedenen Autoimmunkrankheiten.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 189.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 249.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

Literatur

  1. Agarwal M, Thomas K, Peter JV, Jeyaseelan L, Cherian AM (1998) A randomized double-blind sham-controlled study of intrathecal human anti-tetanus immunoglobulin in the management of tetanus. Natl Med J India 11:209–912

    PubMed  CAS  Google Scholar 

  2. Andresen I, Kovarik JM, Spycher M, Bolli R (2000) Product equivalence study comparing the tolerability, pharmacokinetics, and pharmacodynamics of various human immunoglobulin-G formulations. J Clin Pharmacol 40:722–730

    Article  PubMed  CAS  Google Scholar 

  3. Anonymous (1999) Report of an IUIS Scientific Committee: Primary Immunodeficiency Diseases. Clin exp Immunol 118 (Suppl):1–28

    Google Scholar 

  4. Berger A, Doerr HW, Scharrer I, Weber B (1997) Follow-up of four HIV-infected individuals after administration of hepatitis C virus and GBV-C/hepatitis G virus contaminated intravenous immunoglobulin: evidence for HCV but not for GBV-C/HGV transmission. J Med Virol 53:25–30

    Article  PubMed  CAS  Google Scholar 

  5. Buchwald B, Ahangari R, Weishaupt A, Toyka KV (2002) Intravenous immunoglobulins neutralize blocking antibodies in Guillain-Barré syndrome. Ann Neurol 51:673–680

    Article  PubMed  CAS  Google Scholar 

  6. Bundesärztekammer auf Empfehlung ihres Wissenschaftlichen Beirats (Hrsg) (2008) Querschnitts-Leitlinien (BÄK) zur Therapie mit Blutkomponenten und Plasmaderivaten. Deutscher Ärzte-Verlag, Köln

    Google Scholar 

  7. Cohen A (2008) How effective is intraveous immunoglobulin for the treatment of relapsing-remitting multiple sclerosis? Nat Clin Pract Neurol 4:588–589

    Article  PubMed  CAS  Google Scholar 

  8. Czermak BJ, Sarma V, Person CL, et al. (1999) Protective effects of C5 a blockade in sepsis. Nature Med 5:788–793

    Article  PubMed  CAS  Google Scholar 

  9. Danieli MG, Malcangi G, Palmieri C, et al. (2002) Cyclosporin A and intravenous immunoglobulin treatment in polymyositis/dermatomyositis. Ann Rheum Dis 61:37–41

    Article  PubMed  CAS  Google Scholar 

  10. Daw Z, Padmore R, Meurath D, Cober N, et al (2008) Hemolytic transfusion reactions after administraton of intravenous immune (gamma) globulin: a case series analysis. Transfusion 48:1598–1601

    Article  PubMed  Google Scholar 

  11. Douzinas EE, Pitaridis MT, Louris G, et al. (2000) Prevention of infection in multiple trauma patients by high-dose intravenous immunoglobulins. Crit Care Med 28:8–15

    Article  PubMed  CAS  Google Scholar 

  12. Doorn, van PA, Ruts L, Jacobs BC (2008) Clinical features, pathogenesis, and treatment of GuillainBarré syndrome. Lancet Neurol 7:939–950

    Article  PubMed  Google Scholar 

  13. Habib S, Shaikh OS (2007) Hepatitis B immunoglobulin. Drugs Today 43:379–394

    Article  PubMed  CAS  Google Scholar 

  14. Hartung HP (2008) Advances in the understanding of the mechanisms of action of IVIg. J Neurol 255 (Suppl 3):3–6

    Article  PubMed  CAS  Google Scholar 

  15. Jolles S (2001) A review of high-dose intravenous immunoglobulin (hdIVIg) in the treatment of autoimmune blistering disorders. Clin Exp Dermatol 26:127–131

    Article  PubMed  CAS  Google Scholar 

  16. Kanra G, Ozon A, Vajsar J, et al. (1997) Intravenous immunoglobulin treatment in children with Guillain-Barré syndrome. Eur J Paediatr Neurol 1:7–12

    Article  PubMed  CAS  Google Scholar 

  17. Kreymann KG, de Heer G, Nierhaus A, Kluge S (2007) Use of polyclonal immunoglobulins as adjunctive therapy for sepsis or septic shock. Crit Care Med 35:2677–2685

    Article  PubMed  CAS  Google Scholar 

  18. Lalive PH (2008) Autoantibodies in inflammatory demyelinating diseases of the central nervous system. Swiss Med Wkly 138:692–707

    PubMed  Google Scholar 

  19. Lee ML, Gale RP, Yap PL (1997) Use of intravenous immunogobulin to prevent or treat infections in persons with immune deficiency. Ann Rev Med 48:93–102

    Article  PubMed  CAS  Google Scholar 

  20. Levy Y, Sherer Y, Ahmed AR, Langetwitz P, et al. (1999) A study of 20 SLE patients with intravenous immunoglobulin – clinical and serologic response. Lupus 8:705–712

    Article  PubMed  CAS  Google Scholar 

  21. Meuer M (2001) Immunglobulintherapie in der Dermatologie – Indikation und Durchführung. Z Hautkrankh 76:65

    Google Scholar 

  22. Mignogna MD, Leuci S, Fedele S, et al. (2008) Adjuvant high-dose intravenous immunoglobulin therapy can be easily and safely introduced as an alternative treatment in patients with severe pemphigus vulgaris: a retrospective preliminary study. Am J Clin Dermatol 9:323–331

    Article  PubMed  Google Scholar 

  23. Mofenson LM, Korelitz J, Meyer WA, et al. (1997) The relationship between serum human immunodeficiency virus type 1 (HIV-1) RNA level, CD4 lymphocyte percent, and long-term mortality risk in HIV-1-infected children. National Institute of Child Health and Human Development Intravenous Immunoglobulin Clinical Trial Study Group. J Infect Dis 175:1029–1038

    Article  PubMed  CAS  Google Scholar 

  24. Muller R, Gubernatis G, Farle M, et al. (1991) Liver transplantation in HBs antigen (HBsAg) carriers. Prevention of hepatitis B virus (HBV) recurrence by passive immunization. J Hepatol 13:90–96

    Article  PubMed  CAS  Google Scholar 

  25. Nau GJ, Richmond JFL, Schlesinger A, Jennings EG, Lander ES, Young RA (2002) Human macrophage activation programs induced by bacterial pathogens. PNAS 99:1503–1508

    Article  PubMed  CAS  Google Scholar 

  26. Nydegger UE (2009) Immunoglobulins in Clinical Medicine. Rossi’sPrinciples in Transfusion Medicine, 4thedn. Wiley Blackwell, Chichester, pp 260–272

    Google Scholar 

  27. Ohlsson A, Lacy JB (2010) Intravenous immunoglobulin for suspected or subsequently proven infection in neonates. Cochrane Database Syst Rev 2010, Issue 3, Art. No.CD001239

    Google Scholar 

  28. Okada K, Hara J, Maki I, et al. (2009) Pulse treatment with gammaglobulin as an initial treatment for acute Kawasaki disease. Eur J Pediatr 168:181–18

    Article  PubMed  CAS  Google Scholar 

  29. Pan Q, Hammarström L (2000) Molecular basis of IgG subclass deficiency. Immunol Rev 178:99–110

    Article  PubMed  CAS  Google Scholar 

  30. Samuelsson A, Towers TL, Ravetch JV (2001) Anti-inflammatory activity of IVIG mediated through the inhibitory Fc receptor. Science 291:484–486

    Article  PubMed  CAS  Google Scholar 

  31. Schumann A, Lindemann M, Valentin-Gamazo C, Lu M, et al. (2009) Adoptive immune transfer of hepatitis B virus specific immunity from immunized living liver donors to liver recipients. Transplantation 87:103–111

    Article  PubMed  CAS  Google Scholar 

  32. Siberil S, Ellurur S, Graff-Dubois S, et al. (2007) Intravenous immunoglobulins in autoimmune and inflammatory diseases: a mechanistic perspective. Ann N Y Acad Sci 1110:497–506

    Article  PubMed  CAS  Google Scholar 

  33. Stiehm ER (1991) Use of immunogloblin therapy in secondary antibody deficiencies. In: Imbach P (ed) Immunotherapy with intravenous immunoglobulins. Academic Pres, New York, pp 115–125

    Google Scholar 

  34. Viard I, Wehrli P, Bullani R, et al. (1998) Inhibition of toxic epidermal necrolysis by blockade of CD95 with human intravenous immunoglobulin. Science 282:490–493

    Article  PubMed  CAS  Google Scholar 

  35. Wassmuth R, Hauser IA, Schuler K, et al. (2001) Differential inhibitory effects of intravenous immunoglobulin preparations on HLA-alloantibodies in vitro. Transplantation 71:1436–1442

    Article  PubMed  CAS  Google Scholar 

  36. Werdan K Oilz G, Bujdoso O, et al. (2007) Score-based immunoglobulin G therapy of patients with sepsis: the SBITS study. Crit Care Med 35:2693–2701

    Article  PubMed  CAS  Google Scholar 

  37. Winston DJ, Antin JH, Wolff SN, et al. (2001) A multicenter, randomized, double-blind comparison of different doses of intravenous immunoglobulin for prevention of graft-vs.-host disease and infection after allogeneic bone marrow transplantation. Bone Marrow Transplant 28:18796

    Article  Google Scholar 

  38. Wymann S, Ghielmetti M, Schaub A, et al. (2008) Monomerization of dimeric IgG of intravenous immunoglobulin (IVIg) increases the antibody reactivity against intracellular antigens. Mol Immunol 45:2621–2628

    Article  PubMed  CAS  Google Scholar 

  39. Yamada H, Morikawa M, Furuta I, Kato EH, et al. (2003) Intravenous immunoglobulin treatment in women with recurrent abortions: increased cytokine levels and reduced Th1/Th2 lymphocyte ration in peripheral blood. Am J reprod Immunol 49:84–89

    Article  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Labormedizinisches Zentrum Dr. Risch, Universitätsklinikum Rostock (AÖR), Waldeggstrasse 37, CH-3097, Liebefeld (Bern)

    Prof. Dr. U. Nydegger

Authors
  1. Prof. Dr. U. Nydegger
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung für Transfusionsmedizin, Universitätsklinikum Rostock AöR, Ernst-Heydemann-Str. 6, 18057, Rostock

    Volker Kiefel

Rights and permissions

Reprints and permissions

Copyright information

© 2010 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Nydegger, U. (2010). Therapie mit Immunglobulinen. In: Kiefel, V., Mueller-Eckhardt, C. (eds) Transfusionsmedizin und Immunhämatologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-12765-6_29

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-12765-6_29

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-12764-9

  • Online ISBN: 978-3-642-12765-6

  • eBook Packages: Medicine (German Language)

Publish with us

Policies and ethics

Search

Navigation