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Role of GH/IGF-I Deficiency in Aging

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Laron Syndrome - From Man to Mouse

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Our laboratory and others have been able to use the GHR−/− mice to elucidate the impacts of GH on aging. While many questions persist, these mice have helped to establish that a lack of GH action can extend life span in a manner similar to caloric restriction. Moreover, insulin sensitivity appears to be the most prominent mechanism shared between these two interventions that result in life span extension. Further analysis of the contribution of each of the ­insulin-sensitive tissues as they relate to GH should help focus on these mechanisms. Thus, our laboratory is currently generating liver, muscle, and adipose tissue-specific GHR gene disrupted mice. By investigating the dynamic interactions between GH and insulin signaling within these tissues, how they alter the physiology of other tissues in compensation for the lack of GHR, and the effect on aging will further our understanding of the GH-related mechanisms that extend longevity.

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Authors and Affiliations

  1. Edison Biotechnology Institute, Ohio University, 1 Water Tower Drive, The Ridges, Athens, OH, 45701, USA

    Edward O. List

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  1. Edward O. List
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Correspondence to Edward O. List .

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Editors and Affiliations

  1. Endocrinology & Diabetes Research Unit, Schneider Children's Hospital, Kaplan Street 14, Petah Tikva, 49 202, Israel

    Zvi Laron

  2. Edison Biotechnology Institute, Ohio University, Athens, 45701, Ohio, USA

    J. Kopchick

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List, E.O. (2011). Role of GH/IGF-I Deficiency in Aging. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_50

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  • DOI: https://doi.org/10.1007/978-3-642-11183-9_50

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