Core Message
Both children with Laron syndrome (LS) and those with congenital isolated GH deficiency (IGHD) were found to have reduced muscle force and endurance. Replacement treatment with IGF-I of LS patients was less effective than that with hGH in IGHD patients in restoring muscle force.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Berne RM, Levy MN (1988) Physiology, 2nd edn. Mosby, St. Louis
Brat O, Ziv I, Klinger B, Avraham M, Laron Z (1997) Muscle force and endurance in untreated and human growth hormone or insulin-like growth factor-I-treated patients with growth hormone deficiency or Laron syndrome. Horm Res 47:45–48
Christiansen JS, Jørgensen JO, Pedersen SA, Møller J, Jørgensen J, Skakkeboek NE (1990) Effects of growth hormone on body composition in adults. Horm Res 33(Suppl 4):61–64
Cuneo RC, Wallace JD (2005) Skeletal and cardiac muscle in adults with growth hormone deficiency. In:Jorgensen JOL, Christiansen JE (eds) Growth hormone deficiency in adults. Front Horm Res 33:121–145
Cuneo RC, Salomon F, Wiles CM, Hesp R, Sönksen PH (1991) Growth hormone treatment in growth hormone-deficient adults. I. Effects on muscle mass and strength. J Appl Physiol 70:688–694
Laron Z (1993) Laron Syndrome: from description to therapy. The Endocrinologist 3:21–28
Laron Z (1995) Prismatic cases: Laron Syndrome (primary growth hormone resistance). From patient to laboratory to patient. J Clin Endocrinol Metab 80:1526–1573
Rutherford OM, Beshyah SA, Schott J, Watkins Y, Johnston DG (1995) Contractile properties of the quadriceps muscle in growth hormone-deficient hypopituitary adults. Clin Sci (Lond) 88:67–71
Sartorio A, Narici M, Conti A, Monzani M, Faglia G (1995) Quadriceps and hand-grip strength in adults with childhood-onset growth hormone deficiency. Eur J Endocrinol 132: 37–41
Shurka E, Laron Z (1975) Adjustment and rehabilitation problems of children and adolescents with growth retardation. I. Familial dwarfism with high plasma immunoreactive human growth hormone. Isr J Med Sci 11:352–357
Ziv I, Lev A, Dressler R, Achiron A, Djaldetti R, Melamed E (1992) Clinical assessment of motor deficit. The dilemma and a suggested computerized solution. N Trends Clin Neuropharmacol 5:73–77
Ziv I, Achiron A, Djaldetti R, Dressler R, Melamed E (1993) Short-term beneficial effect of deprenyl monotherapy in early Parkinson’s disease: a quantitative assessment. Clin Neuropharmacol 16:54–60
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Berlin Heidelberg
About this chapter
Cite this chapter
Laron, Z. (2011). Muscle Force and Endurance in Untreated Adult and IGF-I Treated Children with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_17
Download citation
DOI: https://doi.org/10.1007/978-3-642-11183-9_17
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11182-2
Online ISBN: 978-3-642-11183-9
eBook Packages: MedicineMedicine (R0)