Core Message
The serum levels of sex hormone binding proteins in untreated and IGF-I treated patients are shown and their meaning discussed.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Damassa DA, Lin TM, Sponnenschein C, Soto AM (1991) Biological effects of sex hormone-binding globulin on androgen-induced proliferation and androgen metabolism in LNCaP prostate cells. Endocrinology 129:75–84
Gafny M, Silbergeld A, Klinger B, Wasserman M, Laron Z (1994) Comparative effects of GH, IGF-I and insulin on sex hormone binding globulin. Clin Endocrinol 41:169–175
Klinger B, Anin S, Silbergeld A, Eshet R, Laron Z (1998) Development of hyperandrogenism during treatment with insulin-like growth factor-I (IGF-I) in female patients with Laron syndrome. Clin Endocrinol 48:81–87
Laron Z, Klinger B (1998) Effect of insulin-like growth factor -I treatment on serum androgens and testicular and penile size in males with Laron syndrome (primary growth hormone resistance). Eur J Endocrinol 138:176–180
Laron Z, Silbergeld A, Klinger B (1998) Hyperandrogenism induced by insulin-like growth factor-I (IGF-I) treatment of two girls with Laron Syndrome. Children’s Hosp Quart 10:75–79
Nakhla AM, Khan MS, Rosner W (1990) Biologically active steroids activate receptor-bound human sex hormone-binding globulin to cause LNCaP cells to accumulate adenosine 3’, 5’-monophosphate. J Clin Endocrinol 71:398–404
Rosner W (1990) The functions of corticosteroid-binding globulin and sex hormone-binding globulin: recent advances. Endocrine Rev 11:80–91
von Schoulz B, Carlstrom K (1989) On the regulation of sex-hormone-binding globulin-a challenge of an old dogma and outlines of an alternative mechanism. J Steroid Biochem 32:327–34, Review
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2011 Springer Berlin Heidelberg
About this chapter
Cite this chapter
Laron, Z., Kauli, R. (2011). Sex Hormone Binding Proteins and Sex Hormones in Untreated and IGF-I Treated Patients with Laron Syndrome. In: Laron, Z., Kopchick, J. (eds) Laron Syndrome - From Man to Mouse. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-11183-9_11
Download citation
DOI: https://doi.org/10.1007/978-3-642-11183-9_11
Published:
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-642-11182-2
Online ISBN: 978-3-642-11183-9
eBook Packages: MedicineMedicine (R0)