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Comparative and Veterinary Pharmacology pp 213–226Cite as

Genetically Modified Animals and Pharmacological Research

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Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 199))

Abstract

This chapter reviews the use of genetically modified animals and the increasingly detailed knowledge of the genomes of the domestic species. The different approaches to genetic modification are outlined as are the advantages and disadvantages of the techniques in different species. Genetically modified mice have been fundamental in understanding gene function and in generating affordable models of human disease although these are not without their drawbacks. Transgenic farm animals have been developed for nutritionally enhanced food, disease resistance and xenografting. Transgenic rabbits, goats, sheep and cows have been developed as living bioreactors producing potentially high value biopharmaceuticals, commonly referred to as “pharming”. Domestic animals are also important as a target as well as for testing genetic-based therapies for both inherited and acquired disease. This latter field may be the most important of all, in the future development of novel therapies.

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Authors and Affiliations

  1. Department of Veterinary Basic Sciences, Royal Veterinary College, London, NW1 OTU, UK

    Dominic J. Wells

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  1. Dominic J. Wells
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Correspondence to Dominic J. Wells .

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Editors and Affiliations

  1. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Fiona Cunningham

  2. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Jonathan Elliott

  3. Dept. Veterinary Basic Sciences, Royal Veterinary College, Hawkshead Lane, Hertfordshire, AL9 7TA, United Kingdom

    Peter Lees

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Wells, D.J. (2010). Genetically Modified Animals and Pharmacological Research. In: Cunningham, F., Elliott, J., Lees, P. (eds) Comparative and Veterinary Pharmacology. Handbook of Experimental Pharmacology, vol 199. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-10324-7_9

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