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Skin Cancer - A World-Wide Perspective pp 33–34Cite as

Epidemiology of Histocytoses

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Abstract

Langerhans cell histiocytisis (LCH) is the most common of the histiocytic disorders [39]. It represents a spectrum of several clinical entities chracterized by a disorder of antigenpresenting dendritic cells of the immune system. Its epidemiology is poorly understood and based mainly on a few international and regional studies of defined populations [34]. The overall incidence rate varies from 2.6 to 8.9 children per million per year [1, 19, 34, 36]. Children of any age can be affected, however the peak age of presentation, in children, is between the ages of one and three [34]. LCH is also diagnosed in adults [37] but only a few reports are available describing LCH patients with onset during adulthood [3]. Some studies reveal a greater prevalence of LCH among male children [19]. On the other hand, in adults, a preponderance of females is documented with onset as late as the ninth decade of life [26]. Dissemitaned LCH is described to present most frequently in the first year of life [19]. Congenital self-healing LCH is an uncommon form of LCH, which is usually present at birth or in the neonatal period [23].

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Authors and Affiliations

  1. Department of Dermatology F2, University Hospital of Zürich, Gloriastrasse 31, 8091, Zürich, Switzerland

    Marie C. Zipser

  2. Department of Dermatology, University Hospital of Zürich, Gloriastrasse 31, 8091, Zürich, Switzerland

    Reinhard Dummer

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  1. Marie C. Zipser
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Correspondence to Reinhard Dummer .

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Editors and Affiliations

  1. Dermatologische Klinik, Universitätsspital Zürich, Gloriastr. 31, Zürich, 8091, Switzerland

    Reinhard Dummer

  2. Mayo Clinic, Dept. Dermatology, Mayo Clinic College of Medicine, 1st St SW., 200, Rochester, 55905, Minnesota, USA

    Mark R. Pittelkow

  3. Graduate School of Medicine, Dentistry &, Pharmaceutical Sciences, Okayama University, Shikata-cho 2-5-1, Okayama, 700-8558, Japan

    Keiji Iwatsuki

  4. Royal Brisbane Hospital, Queensland Institute of Medical Research, Brisbane, 4029, Queensland, Australia

    Adèle Green

  5. Fac. Medicine, Dept. Dermatology, Tanta University, Tanta, Egypt

    Nagwa M. Elwan

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Zipser, M.C., Dummer, R. (2010). Epidemiology of Histocytoses. In: Dummer, R., Pittelkow, M., Iwatsuki, K., Green, A., Elwan, N. (eds) Skin Cancer - A World-Wide Perspective. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-05072-5_4

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  • DOI: https://doi.org/10.1007/978-3-642-05072-5_4

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