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The Role of Insulin Dysregulation in Aging and Alzheimer’s Disease

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Diabetes, Insulin and Alzheimer's Disease

Part of the book series: Research and Perspectives in Alzheimer's Disease ((ALZHEIMER))

Abstract

Our knowledge of the multifaceted role of insulin in the central nervous system has expanded rapidly in recent years. It is now apparent that perturbation of this role by insulin resistance and hyperinsulinemia can increase the risk for aging-related neurodegenerative disorders such as Alzheimer’s disease (AD) through a number of mechanistic pathways, delineated in elegant in vitro and animal studies. We have investigated these pathways in humans using models of insulin resistance and hyperinsulinemia. We will present results suggesting that insulin-associated effects on Aβ regulation and inflammation contribute to AD pathophysiology. This premise raises the possibility that treatments aimed at improving insulin resistance will benefit patients with AD. We will review data testing this possibility in pilot therapeutic trials using insulin sensitizers and intranasal insulin.

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Aknowledgments

This work was supported by the Department of Veterans Affairs, the National Institute on Aging (RO1 AG10880), the Institute for the Study of Aging, and GlaxoSmithKline.

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  1. GRECC S-182, VAPSHCS, Department of Psychiatry and Behavioral Sciences, University of Washington School of Medicine, 1660 South Columbian Way, Seattle, WA, 98108, USA

    Suzanne Craft

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Correspondence to Suzanne Craft .

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  1. School of Medicine, University of Washington, S. Columbian Way 1660, Seattle, 98108, USA

    Suzanne Craft

  2. Recherche Therapeutique, Fondation IPSEN pour la, quai George Gorse 65, Boulogne Billancourt Cedex, 92650, France

    Yves Christen

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Craft, S. (2010). The Role of Insulin Dysregulation in Aging and Alzheimer’s Disease. In: Craft, S., Christen, Y. (eds) Diabetes, Insulin and Alzheimer's Disease. Research and Perspectives in Alzheimer's Disease. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-04300-0_8

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