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Synthesis, Characterization and Antiviral Activity of Cyanoacrylates and Derivatives

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Environment-Friendly Antiviral Agents for Plants

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Abstract

A series of novel cyanoacrylate derivatives 2.2a-2.2t containing phosphonyl moieties were synthesized by treatment of alkyl 2-cyano-3,3-dimethylthioacrylates and dialkyl phosphites with NaH in THF solvent. This method is easy and generates the title compounds in moderate yields. The structures were verified by spectroscopic data. In the antifungal bioassay, the title compounds 2.2d and 2.22t were found to possess the highest activities against three kinds of fungi in vitro. The bioassay results showed that these title compounds exhibited moderate to good anti-TMV bioactivity. Title compounds 2.2a and 2.2b showed better biological activity than their structurally related analogues 2.2c-2.2t.

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  1. Center for R&D of Fine Chemicals, Guizhou University, Guiyang, 550025, China

    Baoan Song, Linhong Jin, Song Yang & Pinaki S. Bhadury

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  1. Baoan Song
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Song, B., Jin, L., Yang, S., Bhadury, P.S. (2010). Synthesis, Characterization and Antiviral Activity of Cyanoacrylates and Derivatives. In: Environment-Friendly Antiviral Agents for Plants. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-03692-7_3

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