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Supratentorial High-Grade Gliomas

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Oncology of CNS Tumors

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Abstract

Central nervous system (CNS) tumors account for 20–25% of all childhood neoplasms, and their incidence is second only to hematologic malignancies [45]. In addition, they are the third leading cause of death in children less than 16 years of age. The majority of supratentorial primary brain tumors in children are gliomas.

Fortunately, low-grade gliomas account for 60–80% of supratentorial hemispheric tumors in children; these tumors occur at an incidence of approximately five in one million children per year [36, 47, 51]. High-grade gliomas (HGG), equivalent to malignant gliomas, account for the remaining 20–40% [2]. Overall, HGGs account for approximately 6.5% of all newly diagnosed childhood intracranial tumors [47]. There does not appear to be any influence of gender or race on incidence [5]. Tumors metastatic to the CNS are rare in children.

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Author information

Authors and Affiliations

  1. Department of Neurological Surgery, University of California, San Francisco, CA, 94143, USA

    Phiroz E. Tarapore

  2. Department of Neurologic Surgery and Pediatrics, University of California, San Francisco, CA, 94143-0112, USA

    Anu Banerjee

  3. UCSF Neurosurgery, 505 Parnassus Avenue, Room M779, San Francisco, CA, 94143-0112, USA

    Nalin Gupta

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  1. Phiroz E. Tarapore
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  2. Anu Banerjee
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  3. Nalin Gupta
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Editors and Affiliations

  1. Universitätsklinikum München Klinikum Großhadern Neurochirurgische Klinik, Marchioninistr. 15, München, 81377, Germany

    Jörg-Christian Tonn

  2. Universitätsklinikum Hamburg Krankenhaus Eppendorf Klinik und Poliklinik für Neurochirurgie, Martinistr. 52, Neurologie, Hamburg, 20246, Germany

    Manfred Westphal

  3. Division of Neurosurgery, The Hospital for Sick Children, 555 University Avenue Suite 1502, Toronto, ON, M5G 1X8, Canada

    James T. Rutka

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Tarapore, P.E., Banerjee, A., Gupta, N. (2010). Supratentorial High-Grade Gliomas. In: Tonn, JC., Westphal, M., Rutka, J.T. (eds) Oncology of CNS Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02874-8_26

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  • DOI: https://doi.org/10.1007/978-3-642-02874-8_26

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