Skip to main content

Paediatric Bone Scintigraphy: Benign Bone Disease

  • Chapter
  • First Online:
Radionuclide and Hybrid Bone Imaging

Abstract

Bone scintigraphy is a commonly performed nuclear medicine technique in the assessment of non-malignant skeletal pathology in children. A description of the mechanisms and bone scintigraphic findings of benign bone disease is presented along with relevant correlative radiological and F18-FDG PET/CT imaging.

Topics covered include bone and joint infections (of both neonates and older children), benign focal bone lesions, the osteochondroses and complications of slipped capital femoral epiphyses. The various patterns of skeletal trauma are presented including various manifestations of non-accidental injury, toddlers’ fractures and sports-related injury.

Scintigraphic findings in chronic recurrent multifocal osteomyelitis and sarcoidosis are also presented.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 229.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 299.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Similar content being viewed by others

References

  • Aigner RM, Fueger GF et al (1996) Follow-up of osteomyelitis of infants with systemic serum parameters and bone scintigraphy. Nucl Med 35(4):116–121

    CAS  Google Scholar 

  • Azouz EM (2002) Magnetic resonance imaging of benign bone lesions: cysts and tumors. Top Magn Reson Imaging 13(4):219–229

    Article  PubMed  Google Scholar 

  • Biermann JS (2002) Common benign lesions of bone in children and adolescents. J Pediatr Orthop 22(2): 268–273

    PubMed  Google Scholar 

  • Bjorksten B, Boquist L (1980) Histopathological aspects of chronic recurrent multifocal osteomyelitis. J Bone Joint Surg Br 62(3):376–380

    Google Scholar 

  • Bognar M, Blake W et al (1998) Chronic recurrent multifocal osteomyelitis associated with Crohn’s disease. Am J Med Sci 315(2):133–135

    Article  PubMed  CAS  Google Scholar 

  • Bousvaros A, Marcon M et al (1999) Chronic recurrent multifocal osteomyelitis associated with chronic inflammatory bowel disease in children. Dig Dis Sci 44(12):2500–2507

    Article  PubMed  CAS  Google Scholar 

  • Bressler EL, Conway JJ et al (1984) Neonatal osteomyelitis examined by bone scintigraphy. Radiology 152(3):685–688

    PubMed  CAS  Google Scholar 

  • Canale ST, Harkness RM et al (1985) Does aspiration of bones and joints affect results of later bone scanning? J Pediatr Orthop 5(1):23–26

    Article  PubMed  CAS  Google Scholar 

  • Chapurlat RD, Meunier PJ (2000) Fibrous dysplasia of bone. Best Pract Res Clin Rheumatol 14(2):385–398

    Article  CAS  Google Scholar 

  • Connolly LP, Treves ST (1998) Benign conditions. Pediatric skeletal scintigraphy. Springer, New York, pp 135–210

    Book  Google Scholar 

  • Conway JJ, Collins M et al (1993) The role of bone scintigraphy in detecting child abuse. Semin Nucl Med 23(4):321–333

    Article  PubMed  CAS  Google Scholar 

  • Danigelis JA (1976) Pinhole imaging in Legg-Perthes disease: further observations. Semin Nucl Med 6(1):69–82

    Article  PubMed  CAS  Google Scholar 

  • Danigelis JA, Fisher RL et al (1975) 99m-to-polyphosphate bone imaging in Legg-Perthes disease. Radiology 115(2):407–413

    PubMed  CAS  Google Scholar 

  • Dessi A, Crisafulli M et al (2008) Osteo-articular infections in newborns: diagnosis and treatment. J Chemother 20(5):542–550

    PubMed  CAS  Google Scholar 

  • Doyle SM, Monahan A (2010) Osteochondroses: a clinical review for the pediatrician. Curr Opin Pediatr 22(1):41–46

    Article  PubMed  Google Scholar 

  • Dunbar JS, Owen HF et al (1964) Obscure tibial fracture of infants – the Toddler’s fracture. J Can Assoc Radiol 15:136–144

    PubMed  CAS  Google Scholar 

  • Duong RB, Nishiyama H et al (1982) Kienbock’s disease: scintigraphic demonstration in correlation with clinical, radiographic, and pathologic findings. A case report. Clin Nucl Med 7(9):418–420

    Article  PubMed  CAS  Google Scholar 

  • El-Shanti HI, Ferguson PJ et al (2007) Chronic recurrent multifocal osteomyelitis: a concise review and genetic update. Clin Orthop Relat Res 462:11–19

    Article  PubMed  Google Scholar 

  • Fritz J, Tzaribatchev N et al (2009) Chronic recurrent multifocal osteomyelitis: comparison of whole-body MR imaging with radiography and correlation with clinical and laboratory data. Radiology 252(3):842–851

    Article  PubMed  Google Scholar 

  • Gips S, Ruchman RB et al (1997) Bone imaging in Kohler’s disease. Clin Nucl Med 22(9):636–637

    Article  PubMed  CAS  Google Scholar 

  • Green NE, Edwards K (1987) Bone and joint infections in children. Orthop Clin North Am 18(4):555–576

    PubMed  CAS  Google Scholar 

  • Greyson ND, Pang S (1981) The variable bone scan appearances of nonosteogenic fibroma of bone. Clin Nucl Med 6(6):242–245

    Article  PubMed  CAS  Google Scholar 

  • Hod N, Levi Y et al (2007) Scintigraphic characteristics of non-ossifying fibroma in military recruits undergoing bone scintigraphy for suspected stress fractures and lower limb pains. Nucl Med Commun 28(1):25–33

    Article  PubMed  Google Scholar 

  • Howman-Giles R, Uren R (1992) Multifocal osteomyelitis in childhood. Review by radionuclide bone scan. Clin Nucl Med 17(4):274–278

    Article  PubMed  CAS  Google Scholar 

  • Jee WH, Choe BY et al (1998) Nonossifying fibroma: characteristics at MR imaging with pathologic correlation. Radiology 209(1):197–202

    PubMed  CAS  Google Scholar 

  • Jones AC, Prihoda TJ et al (2006) Osteoblastoma of the maxilla and mandible: a report of 24 cases, review of the literature, and discussion of its relationship to osteoid osteoma of the jaws. Oral Surg Oral Med Oral Pathol Oral Radiol Endod 102(5):639–650

    Article  PubMed  Google Scholar 

  • Kairemo KJ, Verho S et al (1999) Imaging of McCune-Albright syndrome using bone single photon emission computed tomography. Eur J Pediatr 158(2):123–126

    Article  PubMed  CAS  Google Scholar 

  • Katz JF (1981) Nonarticular osteochondroses. Clin Orthop Relat Res (158):70–76

    Google Scholar 

  • Khanna G, Sato TS et al (2009) Imaging of chronic recurrent multifocal osteomyelitis. Radiographics 29(4):1159–1177

    Article  PubMed  Google Scholar 

  • Kitsoulis P, Mantellos G et al (2006) Osteoid osteoma. Acta Orthop Belg 72(2):119–125

    PubMed  Google Scholar 

  • Kumar R, Dilip S et al (1998) Three-phase bone imaging in the early diagnosis of osteochondritis dissecans of the patella. Clin Nucl Med 23(8):540–541

    Article  PubMed  CAS  Google Scholar 

  • MacLeod MA, Houston AS (1997) Functional bone imaging in the detection of ischemic osteopathies. Clin Nucl Med 22(1):1–5

    Article  PubMed  CAS  Google Scholar 

  • Mandell GA, Harcke HT (1987) Scintigraphic manifestations of infraction of the second metatarsal (Freiberg’s disease). J Nucl Med 28(2):249–251

    PubMed  CAS  Google Scholar 

  • Mandell GA, Keret D et al (1992) Chondrolysis: detection by bone scintigraphy. J Pediatr Orthop 12(1):80–85

    PubMed  CAS  Google Scholar 

  • Mandell GA, Contreras SJ et al (1998) Bone scintigraphy in the detection of chronic recurrent multifocal osteomyelitis. J Nucl Med 39(10):1778–1783

    PubMed  CAS  Google Scholar 

  • Mankin HJ, Trahan CA et al (2009) Non-ossifying fibroma, fibrous cortical defect and Jaffe-Campanacci syndrome: a biologic and clinical review. Musculoskelet Surg 93(1):1–7

    Article  Google Scholar 

  • McCarthy JJ, Dormans JP et al (2005) Musculoskeletal infections in children: basic treatment principles and recent advancements. Instr Course Lect 54:515–528

    PubMed  Google Scholar 

  • McCauley RG, Kahn PC (1977) Osteochondritis of the tarsal navicula: radioisotopic appearances. Radiology 123(3):705–706

    PubMed  CAS  Google Scholar 

  • McCullough CJ (1980) Eosinophilic granuloma of bone. Acta Orthop Scand 51(3):389–398

    PubMed  CAS  Google Scholar 

  • Perlman MH, Patzakis MJ et al (2000) The incidence of joint involvement with adjacent osteomyelitis in pediatric patients. J Pediatr Orthop 20(1):40–43

    PubMed  CAS  Google Scholar 

  • Porn U, Howman-Giles R et al (2003) Langerhans cell histiocytosis of the lumber spine. Clinical Nuclear Medicine 28(1):52–53

    Google Scholar 

  • Rhoad RC, Davidson RS et al (1999) Pretreatment bone scan in SCFE: a predictor of ischemia and avascular necrosis. J Pediatr Orthop 19(2):164–168

    PubMed  CAS  Google Scholar 

  • Siffert RS (1981a) Classification of the osteochondroses. Clin Orthop Relat Res (158):10–18

    Google Scholar 

  • Siffert RS (1981b) The osteochondroses. Clin Orthop Relat Res (158):2–3

    Google Scholar 

  • Slater JM, Swarm OJ (1980) Eosinophilic granuloma of bone. Med Pediatr Oncol 8(2):151–164

    Article  PubMed  CAS  Google Scholar 

  • Song KS, Ogden JA et al (1997) Contiguous discitis and osteomyelitis in children. J Pediatr Orthop 17(4): 470–477

    PubMed  CAS  Google Scholar 

  • Traughber PD, Manaster BJ et al (1986) Negative bone scans of joints after aspiration or arthrography: experimental studies. AJR Am J Roentgenol 146(1):87–91

    PubMed  CAS  Google Scholar 

  • Uren RF, Howman-Giles R (1991) The ‘cold hip’ sign on bone scan. A retrospective review. Clin Nucl Med 16(8):553–556

    Article  PubMed  CAS  Google Scholar 

  • Wiley AM, Trueta J (1959) The vascular anatomy of the spine and its relationship to pyogenic vertebral osteomyelitis. J Bone Joint Surg Br 41-B:796–809

    PubMed  CAS  Google Scholar 

  • Wong M, Isaacs D et al (1995) Clinical and diagnostic features of osteomyelitis occurring in the first three months of life. Pediatr Infect Dis J 14(12):1047–1053

    Article  PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Robert Howman-Giles MB BS, M.D., FRACP, DDU .

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

London, K., Howman-Giles, R. (2012). Paediatric Bone Scintigraphy: Benign Bone Disease. In: Fogelman, I., Gnanasegaran, G., van der Wall, H. (eds) Radionuclide and Hybrid Bone Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02400-9_35

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-02400-9_35

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02399-6

  • Online ISBN: 978-3-642-02400-9

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics