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Pathophysiology of Bone Metastases

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Radionuclide and Hybrid Bone Imaging

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Abstract

Bone metastases are a common occurrence in carcinoma of the breast, prostate and lung. An understanding of the basic biology of metastatic disease is important for an appreciation of the selective nature of these tumour metastases for bone. Biomechanics of metastatic disease helps explain the proclivity of most metastatic disease for the vertebral column. An understanding of pathophysiology and biochemistry helps in understanding how some tumours produce osteolytic versus osteoblastic or mixed lesions and the relative risks of these deposits. This knowledge leads to an understanding of the difficulties in imaging these lesions and how best to utilize techniques such as SPECT/CT, MRI and PET/CT.

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Authors and Affiliations

  1. Concord Nuclear Imaging, 4 Hospital Road, Concord West, Sydney, NSW, 21389, Australia

    Hans Van der Wall M.B.B.S., Ph.D., FRACP

  2. Graduate School of Medicine, University of Wollongong, Wollongong, NSW, Australia

    Barry Elison MBChB, FRACP

  3. Department of Nuclear Medicine, Wollongong Hospital, Wollongong, NSW, Australia

    Barry Elison MBChB, FRACP

  4. Department of Nuclear Medicine, Concord Hospital, Sydney, NSW, Australia

    Clayton Frater Ph.D., ANMT, BHSM

  5. Faculty of Medicine, University of Sydney, Sydney, NSW, Australia

    Warwick Bruce M.B.B.S., FRACS & Stephen Clarke M.B.B.S., Ph.D., FRACP

  6. Department of Orthopedic Surgery, Concord Hospital, Sydney, NSW, Australia

    Warwick Bruce M.B.B.S., FRACS

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  1. Hans Van der Wall M.B.B.S., Ph.D., FRACP
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  2. Barry Elison MBChB, FRACP
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  3. Clayton Frater Ph.D., ANMT, BHSM
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  4. Warwick Bruce M.B.B.S., FRACS
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  5. Stephen Clarke M.B.B.S., Ph.D., FRACP
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Correspondence to Hans Van der Wall M.B.B.S., Ph.D., FRACP .

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Editors and Affiliations

  1. School of Medicine, Dept. Nuclear Medicine, Guy's, King's and St. Thomas', Guy's Campus, London, SE1 9RT, United Kingdom

    Ignac Fogelman

  2. Deptartment of Nuclear Medicine, Guy's and St. Thomas Hospital, St. Thomas Street, London, SE1 9RT, United Kingdom

    Gopinath Gnanasegaran

  3. Dept. Nuclear Medicine &, Nuclear Cardiology, Concord Repatriation General Hospital, Hospital Road, Concord West, 2138, New South Wales, Australia

    Hans van der Wall

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Van der Wall, H., Elison, B., Frater, C., Bruce, W., Clarke, S. (2012). Pathophysiology of Bone Metastases. In: Fogelman, I., Gnanasegaran, G., van der Wall, H. (eds) Radionuclide and Hybrid Bone Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02400-9_3

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  • DOI: https://doi.org/10.1007/978-3-642-02400-9_3

  • Published:

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02399-6

  • Online ISBN: 978-3-642-02400-9

  • eBook Packages: MedicineMedicine (R0)

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