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Morbus Alzheimer und Altersveränderungen des Gehirns

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Pathologie

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Zusammenfassung

Dieses Kapitel behandelt die nicht-krankhaften Altersveränderungen des Gehirns (Lipofuszin, Axonauftreibungen, verschiedene Einschlüsse) sowie die Charakteristika der Alzheimer-Krankheit (senile Plaques, tangles, Neuropilfäden, Aß- und tau-Pathologie). Detailliert wird auf neuropathologische Klassifikationen der Alzheimer-Krankheit eingegangen (Braak-Stadien, Thal-Phasen, CERAD-Kriterien, NIH-AA-Kriterien). Ferner werden Sonderformen der Alzheimer-Krankheit und die genetischen Grundlagen besprochen.

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Authors and Affiliations

  1. Institut für Pathologie – Labor für Neuropathologie, Universitätsklinikum Ulm, Albert-Einstein-Allee 11, 89081, Ulm, Deutschland

    Dietmar Rudolf Thal

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  1. Dietmar Rudolf Thal
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Editors and Affiliations

  1. Institut für Pathologie Konsultationszentrum für Pankreas- und Endokrine Tumore, TU München, Ismaninger Straße 22, 81675, München, Deutschland

    Günter Klöppel (Werkherausgeber) (Werkherausgeber)

  2. Zentrum Pathologie und Rechtsmedizin, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Straße 1, 30625, Hannover, Deutschland

    Hans H. Kreipe (Werkherausgeber) (Werkherausgeber)

  3. Institut für Pathologie, Kliniken der Landeshauptstadt, Ludwig-Erhard-Straße 100, 65199, Wiesbaden, Deutschland

    Wolfgang Remmele (Werkherausgeber) (Werkherausgeber)

  4. Institut für Neuropathologie, Universitätsklinikum Münster, Domagkstraße 19, 48149, Münster, Deutschland

    Werner Paulus (Bandherausgeber) (Bandherausgeber)

  5. Institut für Neuropathologie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule (RWTH) Aachen, Pauwelsstraße 30, 52074, Aachen, Deutschland

    J. Michael Schröder (Bandherausgeber) (Bandherausgeber)

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Thal, D. (2012). Morbus Alzheimer und Altersveränderungen des Gehirns. In: Klöppel, G., Kreipe, H., Remmele, W., Paulus, W., Schröder, J. (eds) Pathologie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02324-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-02324-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02323-1

  • Online ISBN: 978-3-642-02324-8

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