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Intestine Transplantation in Children

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Textbook of Clinical Pediatrics
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Background

Intestinal transplantation has made dynamic progress in the last 20 years, benefiting from important developments in preservation technology, surgical technique, improved perioperative care, and innovative immunosuppressive strategies. It is now recognized as an established modality of care for patients suffering from failure of their intestinal function and requiring Total Parenteral Nutrition (TPN). The dramatically improved outcomes for intestinal transplantation over the last decade have allowed more patients to benefit from this therapy. More importantly, however, an important component of the legacy of intestinal transplantation has been the development of intestinal failure management which has opened a focus of multidisciplinary care to this field. This chapter is intended to review the various components of this field and address the challenges which remain to further progress, which include improvements in intestinal adaptation and prevention of TPN-associated...

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References

  • Abu-Elmagd K, Fung J, Bueno J et al (2000) Logistics and technique for procurement of intestinal, pancreatic, and hepatic grafts from the same donor. Ann Surg 232:680–687

    Article  PubMed  CAS  Google Scholar 

  • Abu-Elmagd KM, Costa G, Bond GJ, Wu T, Murase N, Zeevi A, Simmons R, Soltys K, Sindhi R, Stein W, Demetris A, Mazariegos G (2009) Evolution of the immunosuppressive strategies for the intestinal and multivisceral recipients with special reference to allograft immunity and achievement of partial tolerance. Transpl Int 22(1):96–109

    Article  PubMed  Google Scholar 

  • Akpinar E, Vargas J, Kato T et al (2008) Fecal calprotectin level measurements in small bowel allograft monitoring: a pilot study. Transplantation 85:1281–1286

    Article  PubMed  Google Scholar 

  • ASPEN Board of Directors and Clinical Guidelines Task Force (2004) Guidelines for the use of parenteral and enteral nutrition in adult and pediatric patients. J Parenter Enteral Nutr 28(6):S39–S70

    Article  Google Scholar 

  • Beath S, Pironi L, Gabe S et al (2008) Collaborative strategies to reduce mortality and morbidity in patients with chronic intestinal failure including those who are referred for small bowel transplantation. Transplantation 85:1378–1384

    Article  PubMed  Google Scholar 

  • Berg CL, Steffick DE, Edwards EB et al (2009) Liver and intestine transplantation in the United States 1998–2007. Am J Transplant 9:907–931

    Article  PubMed  CAS  Google Scholar 

  • Ching YA, Fitzgibbons S, Valim C et al (2009) Long-term nutritional and clinical outcomes after serial transverse enteroplasty at a single institution. J Pediatr Surg 44:939–943

    Article  PubMed  Google Scholar 

  • Diamond IR, Sterescu A, Pencharz PB et al (2009) Changing the paradigm: omegaven for the treatment of liver failure in pediatric short bowel syndrome. J Pediatr Gastroenterol Nutr 48:209–215

    Article  PubMed  CAS  Google Scholar 

  • Fishbein T, Novitskiy G, Mishra L et al (2008) NOD2-expressing bone marrow-derived cells appear to regulate epithelial innate immunity of the transplanted human small intestine. Gut 57:323–330

    Article  PubMed  CAS  Google Scholar 

  • Gura KM, Lee S, Valim C et al (2008) Safety and efficacy of a fish-oil-based fat emulsion in the treatment of parenteral nutrition-associated liver disease. Pediatrics 121:e678–e686

    Article  PubMed  Google Scholar 

  • Kato T, Mizutani K, Terasaki P et al (2006) Association of emergence of HLA antibody and acute rejection in intestinal transplant recipients: a possible evidence of acute humoral sensitization. Transplant Proc 38:1735–1737

    Article  PubMed  CAS  Google Scholar 

  • Kocoshis SA, Beath SV, Booth IW et al (2004) Intestinal failure and small bowel transplantation, including clinical nutrition: working group report of the second World Congress of Pediatric Gastroenterology, Hepatology, and Nutrition. J Pediatr Gastroenterol Nutr 39:S655–S661

    Article  PubMed  Google Scholar 

  • Mazariegos GV, Steffick DE, Horslen S, Farmer D, Fryer J, Grant D, Langnas A, Magee JC (2010a) Intestine transplantation in the United States 1999–2008. Am J Trans 10:1020–1034. Special Issue: The 2009 SRTR Report on the State of Transplantation

    Google Scholar 

  • Mazariegos GV, Steffick DE, Horslen S, Farmer D, Fryer J, Grant D, Langnas A, Magee JC (2010b) Intestine transplantation in the United States 1999–2008. Am J Transplant 10:1020–1034

    Article  PubMed  CAS  Google Scholar 

  • Mazariegos GV, Abu-Elmagd K, Jaffe R et al (2004) Graft versus host disease in intestinal transplantation. Am J Transplant 4:1459–1465

    Article  PubMed  Google Scholar 

  • Nishida S, Levi DM, Moon JI, Madariaga JR, Kato T, Selvaggi G, Tryphonopoulos P, DeFaria W, Santiago S, Gaynor J, Weppler D, Martinez E, Ruiz P, Tzakis AG (2004) Intestinal transplantation with alemtuzumab (Campath-1 H) induction for adult patients. Transplant Proc 38(6):1747–1749

    Article  Google Scholar 

  • Nodit L, Murase N, Reyes JD et al (2004) Transient posttransplant graft-versus-host lymphadenopathy. Pediatr Dev Pathol 7:533–537

    Article  PubMed  Google Scholar 

  • Reyes J, Mazariegos GV, Abu-Elmagd K, Macedo C, Bond GJ, Murase N, Peters J, Sindhi R, Starzl TE (2005) Intestinal transplantation under tacrolimus monotherapy after perioperative lymphoid depletion with rabbit anti-thymocyte globulin (thymoglobulin). Am J Transplant 5(6):1430–1436

    Article  PubMed  CAS  Google Scholar 

  • Spencer AU, Neaga A, West B et al (2005) Pediatric short bowel syndrome: redefining predictors of success. Ann Surg 242:403–409

    PubMed  Google Scholar 

  • Sudan D, Vargas L, Sun Y et al (2007) Calprotectin: a novel noninvasive marker for intestinal allograft monitoring. Ann Surg 246:311–315

    Article  PubMed  Google Scholar 

  • Wu T, Abu-Elmagd K, Bond G, Demetris AJ (2004) A clinicopathologic study of isolated intestinal allografts with preformed IgG lymphocytotoxic antibodies. Hum Pathol 35:1332–1339

    Article  PubMed  CAS  Google Scholar 

  • Zeevi A, Britz JA, Bentlejewski CA et al (2005) Monitoring immune function during tacrolimus tapering in small bowel transplant recipients. Transpl Immunol 15:17–24

    Article  PubMed  CAS  Google Scholar 

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Correspondence to Jorge D. Reyes .

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© 2012 Springer-Verlag Berlin Heidelberg

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Reyes, J.D. (2012). Intestine Transplantation in Children. In: Elzouki, A.Y., Harfi, H.A., Nazer, H.M., Stapleton, F.B., Oh, W., Whitley, R.J. (eds) Textbook of Clinical Pediatrics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02202-9_197

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  • DOI: https://doi.org/10.1007/978-3-642-02202-9_197

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02201-2

  • Online ISBN: 978-3-642-02202-9

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