Skip to main content
SpringerLink
Log in

Surfactant Replacement Therapy

  • Reference work entry
Textbook of Clinical Pediatrics

  • 334 Accesses

Surfactant therapy has changed neonatal respiratory care over the past two decades and dramatically improved neonatal outcome. Pulmonary surfactant is a complex mixture of phospholipids and proteins that reduce surface tension at the air–liquid interface of alveoli. The origin of its name is a collocation of the capitals from the compound lexeme “SURFace ACTive AgeNT”.

In 1929, Kurt von Neergard suggested the presence of pulmonary surfactant in newborn lungs to be followed almost 25 years later by the contributions of R. Pattle, J. Clements and C. Macklin to our understanding of the physiology of pulmonary surfactant. In 1959, M.E. Avery and J. Mead reported that preterm neonates dying from hyaline membrane diseasehad surfactant deficiency. First successful use of bovine surfactant in preterm newborns with respiratory distress syndrome (RDS) was published by T. Fujiwara in 1980. Since then, a number of randomized trials of different natural and synthetic surfactants clearly...

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 999.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Hardcover Book
USD 1,299.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  • Avery ME, Mead J (1959) Surface properties in relation to atelectasis and hyaline membrane disease. Am J Dis Child 97:517–523

    CAS  Google Scholar 

  • Batenburg JJ, Haagsman HP (1998) The lipids of pulmonary surfactant: dynamics and interaction with proteins. Prog Lipid Res 37:235–276

    Article  PubMed  CAS  Google Scholar 

  • Cavicchioli P, Zimmermann LJ, Cogo PE et al (2001) Endogenous surfactant turnover in preterm infants with respiratory mistress syndrome studied with stable isotope lipids. Am J Respir Crit Care Med 163:55–60

    Article  PubMed  CAS  Google Scholar 

  • Clements JA (1956) Dependence of pressure-volume characteristics of lungs on intrinsic surface active material. Am J Physiol 187:592

    Google Scholar 

  • Dunn MS, Shennan AT, Zayack D et al (1991) Bovine surfactant replacement therapy: A comparison of 2 retreatment strategies in premature infants with RDS. Ped Res 29:212A

    Google Scholar 

  • Findlay RD, Taeusch HW, Walther FJ (1996) Surfactant replacement therapy for meconium aspiration syndrome. Pediatrics 97:48–52

    PubMed  CAS  Google Scholar 

  • Fujiwara T, Chida S, Watabe YJ et al (1980) Artificial surfactant therapy in hyaline membrane disease. Lancet i:55–59

    Article  Google Scholar 

  • Haagsman HP, Hogenkamp A, Van Eijk M et al (2008) Surfactant collectins and innate immunity. Neonatology 93:288–294

    Article  PubMed  Google Scholar 

  • Halliday HI (2008) Surfactants: past, present and future. J Perinatol 28:S47–S56

    Article  PubMed  CAS  Google Scholar 

  • Horbar JD, Carpenter JH, Buzas J et al (2004) Timing of initial surfactant treatment for infants 23 to 29 weeks’gestation: Is routine practice evidence based? Pediatrics 113:1593–1602

    Article  PubMed  Google Scholar 

  • Isohama Y, Komanda Y, Tahala K et al (1997) Dexamethason increases beta2-adrenoreceptor-regulated phosphatidylcholin secreation in rat alveolar type II cells. Jap J Pharmacol 73:163–169

    Article  PubMed  CAS  Google Scholar 

  • Jobe AH (2006) Mechanisms to explain surfactant response. Biol Neonate 89:298–302

    Article  PubMed  Google Scholar 

  • Kattwinkel J, Bloom BT, Delmore P et al (2000) High versus Low threshold surfactant retreatment for neonatal respiratory distress syndrome. Pediatrics 106:282–288

    Article  PubMed  CAS  Google Scholar 

  • Kresch MJ, Lima DM, Lu H (1996) Developmental regulation of phospholipid secretion by fetal type II pneumocytes. Biochim Biophys Acta 1299:39–46

    Article  PubMed  Google Scholar 

  • Kuroki Y, Takahashi M, Nishitani C (2007) Pulmonary collectines in innate immunity of the lung. Cell Microbiol 9:1871–1879

    Article  PubMed  CAS  Google Scholar 

  • Liechty EA, Donovan E, Purohit D et al (1991) Reduction of neonatal mortality after multiple doses of bovine surfactant in low birth weight neonates with respiratory distress syndrome. Pediatrics 88:19–28

    PubMed  CAS  Google Scholar 

  • Lundstrom KE, Greisen G (1996) Changes in EEG, systemic circulation and blood gas parameters following two or six aliquots of porcine surfactant. Acta Paediatr 85:708–712

    Article  PubMed  CAS  Google Scholar 

  • Macklin CC (1954) The pulmonary alveolar mucoid film and pneumocyte. Lancet i:1099–1104

    Article  Google Scholar 

  • Moya F, Sinha S, Gadzinowski J et al (2007) One-year follow-up of very preterm infants who received lucinactant for prevention of respiratory distress syndrome: results from 2 multicenter randomized, controlled trials. Pediatrics 119:e1361–e1370

    Article  PubMed  Google Scholar 

  • Pattle RE (1955) Properties, function and origin of alveolar lining layer. Nature 175:1125–1126

    Article  PubMed  CAS  Google Scholar 

  • Sandri F, Plavka R, Ancora G et al (2010) Randomized Controlled trial of prophylactic surfactant compared to early selective surfactant combined with nasal continuous positive airway pressure in very preterm infants: The CURPAP Study. Pediatrics; 125(6): e1402–e1409

    Google Scholar 

  • Server W, Grube C, Gunther A et al (1993) Surfactant inhibition by plasma proteins: differential sensitivity of various surfactant preparations. Eur Resp J 6:971–977

    Google Scholar 

  • Skov L, Bell A, Greisen G (1992) Surfactant administration and the cerebral circulation. Biol Neonate 61(Suppl 1):31–36

    PubMed  Google Scholar 

  • Soll RF (1999) Multiple versus single dose natural surfactant extract for severe neonatal respiratory distress syndrome. Cochrane Database Syst Rev 2:CD000141

    Google Scholar 

  • Soll RF, Blanco F (2001) Natural surfactant extract versus synthetic surfactant for neonatal respiratory distress syndrome. Cochrane Database Syst Rev 2:CD0014444

    Google Scholar 

  • Soll RF, Dargaville P (2000) Surfactant for meconium aspiration syndrome in full term infants. Cochrane Database Syst Rev 2:CD002054

    PubMed  Google Scholar 

  • Soll RF, Morley CJ (2001) Prophylactic versus selective use of surfactant in preventing morbidity and mortality in preterm infants. Cochrane Database Syst Rev 2:CD000510

    PubMed  Google Scholar 

  • Veldhuizen EJA, Haagsman HP (2000) Role of pulmonary surfactant components in surface film formation and dynamics. Biochim Biophys Acta 1467:255–270

    Article  PubMed  CAS  Google Scholar 

  • Von Neergaard K (1929) Neue auffassungen uber einen grundbegriff dr atemmechanik. Die reaktionskraft der lunge, abhangig von der oberflachenspannung in den alveolen. Z Gesamt Exp Med 66:373–394

    Article  Google Scholar 

  • Yost CC, Soll RF (1999) Early versus delayed selective surfactant treatment for neonatal respiratory distress syndrome. Cochrane Database Syst Rev 4:CD001456

    Google Scholar 

  • Zimmermann LJ, Janssen DJ, Tibboel D et al (2005) Surfactant metabolism in the neonates. Biol Neonate 87(4):296–307, Epub 2005 Jun 1. Review

    Article  PubMed  CAS  Google Scholar 

  • Zola EM, Overbach AM, Gunkel JH et al (1993) Treatment investigational new drug experience with Survanta. Pediatrics 91:546–551

    PubMed  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Division of Neonatology, Charles University, Prague, Czech Republic

    Richard Plavka (General Faculty Hospital and 1st Faculty of Medicine)

Authors
  1. Richard Plavka
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Richard Plavka .

Editor information

Editors and Affiliations

  1. Faculty of Medicine, Umm Al-Qura University, Makkah, Saudi Arabia

    Abdelaziz Y. Elzouki (Professor of Pediatrics) (Professor of Pediatrics)

  2. National Center of Allergy, Asthma & Immunology (NCAAI), Riyadh, Saudi Arabia

    Harb A. Harfi (Director) (Director)

  3. Consultant Pediatric Gastroenterology & Hepatology, Islamic Hospital, Amman, Jordan

    Hisham M. Nazer

  4. Seattle Children's Hospital University of Washington, School of Medicine, Seattle, WA, USA

    F. Bruder Stapleton (Professor and Chair Department of Pediatrics) (Professor and Chair Department of Pediatrics)

  5. Alpert Medical School of Brown University, Woman and Infants Hospital, Providence, RI, USA

    William Oh (Professor of Pediatrics) (Professor of Pediatrics)

  6. University of Alabama, Birmingham, AL, USA

    Richard J. Whitley (Professor of Pediatrics) (Professor of Pediatrics)

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer-Verlag Berlin Heidelberg

About this entry

Cite this entry

Plavka, R. (2012). Surfactant Replacement Therapy. In: Elzouki, A.Y., Harfi, H.A., Nazer, H.M., Stapleton, F.B., Oh, W., Whitley, R.J. (eds) Textbook of Clinical Pediatrics. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-02202-9_18

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-02202-9_18

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-02201-2

  • Online ISBN: 978-3-642-02202-9

  • eBook Packages: MedicineReference Module Medicine

Publish with us

Policies and ethics

Search

Navigation