Abstract
Angiogenesis, the formation of new capillaries from pre-existing vessels, plays a critical role during bone regeneration and repair. In addition to an appropriate mechanical environment, sufficient supply of oxygen and nutrients is critical for bone formation.
Mechano-biological models have been previously used to predict the time course of the differentiation process with the mechanical environment as the only regulator of cell activity. Here we propose a mechano-biological model for tissue differentiation where cell activity is regulated by both the local mechanical environment and the local vascularity. Results show a significant effect of the morphology of the new capillary network on bone formation and heterogeneous distributions of cells similar to those seen in histological studies.
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
References
Carter, D. R., P. R. Blenman, G. S. Beaupre. Correlations between mechanical stress history and tissue differentiation in initial fracture healing. J. Orthop. Res. 7, 398–407, 1988.
Claes, L. E., C. A. Heigele. Magnitudes of local stress and strain along bony surfaces predict the course and type of fracture healing. J. Biomechanics 32, 255–266, 1999.
Prendergast, P.J., R. Huiskes, K. Søballe. Biophysical stimuli on cells during tissue differentiation at implants interfaces. J. Biomechanics 30, 539–548, 1997.
Lacroix, D., P. J. Prendergast. A mechano-regulation model for tissue differentiation during fracture healing: analysis of gap size and loading. J. Biomechanics 35, 1163–71, 2002.
Kelly, D. J., P. J. Prendergast. Mechano-regulation of stem cell differentiation and tissue regeneration in osteochondral defects. J. Biomechanics 38, 1413–1422, 2005.
Isaksson, H., O. Comas, C. C. van Donkelaar, J. Mediavilla, W. Wilson, R. Huiskes, K. Ito. Bone regeneration during distraction osteogenesis: Mechano-regulation by shear strain and fluid velocity. Journal of Biomechanics 40, 2002–2011, 2006.
Byrne, D. P., D. Lacroix, J. A. Planell, D. J. Kelly, P. J. Prendergast. Simulation of tissue differentiation in a scaffold as a function of porosity, Young’s modulus and dissolution rate: Application of mechanobiological models in tissue engineering. Biomaterials 28, 5544–5554, 2007.
Geris, L., A. Andreykiv, H. Van Oosterwyck, J. Vander Stolen, F. van Keulen, J. Duyckc, I. Naert. Numerical simulation of tissue differentiation around loaded titanium implants in a bone chamber. J. Biomech. 37, 763–769, 2004.
Hirao, M., N. Tamai, N. Tsumaki, H. Yoshikawa, A. Myoui. Oxygen Tension Regulates Chondrocyte Differentiation and Function during Endochondral Ossification. J. Biol. Chem. 281, 31079–31092, 2006.
Hausman, M. R., M. B. Schaffler, R. J. Majesta. Prevention of fracture healing in rats by an inhibitor of angiogenesis. Bone 29, 560–564, 2001.
Geris, L., A. Gerisch, J. V. Stolen, R. Weiner, H. V. Oosterwyck. Angiogenesis in bone fracture healing: A bioregulatory model. Journal of Theoretical Biology 251, 137–158, 2007.
Carmeliet, P. and M. K. Jain. Angiogenesis in cancer and other diseases. Nature, 407, 249–257, 2000.
Pérez M., P. J. Prendergast. Random-walk model of cell-dispersal included in mechanobiological simulation of tissue differentiation. J. Biomechanics 40, 2244–2253, 2007.
Gerber, H. P., T. H. Vu, A. M. Ryan, J. Kowalski, Z. Werb, N. Ferrara. VEGF couples hypertrophic cartilage remodelling, ossification and angiogenesis during endochondral bone formation. Nat. Med. 5, 623–628, 1999.
Stokes, C. L., D. A. Lauffenburger. Migration of individual microvessel endothelial cells: stochastic model and parameter measurement. J. Cell Sci. 99, 419–430, 1991.
Kenyon, B. M., E. E. Voest, C. C. Chen, E. Flynn, J. Folkman, R. J. D’Amato. A model of angiogenesis in the mouse cornea. Invest Ophthalmol. Vis. Sci. 37, 1625–1632, 1996.
Claes, L., K. Eckert-Hubner, P. Augat. The effect of mechanical stability on local vascularisation and tissue differentiation in callus healing. J. Orthop. Res. 20, 1099–1105, 2002.
Lu, C., R. Marcucio, T. Miclau. Assessing angiogenesis during fracture healing. Iowas Orthop. J. 26, 17–26, 2006.
Götz, H. E., M. Müller, A. Emmel, U. Holzwarth, R. G. Erben, R. Stangl. Effect of surface finish on the osseointegration of laser-treated titanium alloy implants. Biomaterials 25, 4057–4064, 2004.
Author information
Authors and Affiliations
Corresponding author
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2009 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Checa, S., Prendergast, P.J. (2009). Capillary network formation during tissue differentiation. A mechano-biological model. In: Vander Sloten, J., Verdonck, P., Nyssen, M., Haueisen, J. (eds) 4th European Conference of the International Federation for Medical and Biological Engineering. IFMBE Proceedings, vol 22. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-89208-3_525
Download citation
DOI: https://doi.org/10.1007/978-3-540-89208-3_525
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-89207-6
Online ISBN: 978-3-540-89208-3
eBook Packages: EngineeringEngineering (R0)