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Musculoskeletal System

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Pediatric Oncology Nursing

Part of the book series: Pediatric Oncology ((PEDIATRICO))

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Abstract

The two predominant primary bone tumors in children are osteosarcoma (60%) and Ewing's sarcoma (34%). (Solid tumors are detailed in Chap. 3). Combined, these are the most predominant causes of bone tumors in the lower extremities in children (Nagarajan et al. 2002). Upper- and lower-extremity bone tumors are effectively treated with multimodal treatment, which often involves local control by one of two surgical options.

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References

  • Azcona C, Burghard E, Ruza E, Gimeno J, Sierrasesumaga L (2003) Reduced bone mineralization in adolescent survivors of malignant bone tumors: comparison of quantitative ultrasound and dual-energy X-ray absorptiometry. Journal of Paediatric Haematology/Oncology 25(4):297–301

    Article  Google Scholar 

  • Bacci C, Ferrari S, Longhi A, Donati D, Manfrini M, Giacoma S, Briccoli A, Forni C, Galletti S (2003) Nonmetastatic osteo-sarcoma of the extremity with pathological fracture at presentation: local and systemic control by amputation or limb salvage after preoperative chemotherapy. Acta Ortho-paedica Scandinavica 74(4):449–459

    Article  Google Scholar 

  • Barr RD, Sala A (2008) Osteonecrosis in children and adolescents with cancer. Pediatric Blood & Cancer 50(2 Suppl):483–485

    Article  Google Scholar 

  • Cohen LE (2003) Endocrine late effects of cancer treatment. Current Opinion in Pediatrics 15:3–9

    Article  PubMed  Google Scholar 

  • Davis AM, Wright JG, Williams JI, Bombardier C, Griffin A, Bell RS (1996) Development of a measure of physical function for patients with bone and soft tissue sarcoma. Quality of Life Research 5(5):508–516

    Article  PubMed  CAS  Google Scholar 

  • Fink J, Leisenring W, Sullivan K, Sherrard D, Weiss N (1998) Avascular necrosis following bone marrow transplantation: a case-control study. Bone 22:67–71

    Article  PubMed  CAS  Google Scholar 

  • Fuchs B, Kotajaravi BR, Kaufman KR, Sim FH (2003) Functional outcome of patients with rotationplasty about the knee. Clinical Orthopaedics and Related Research 415:52–58

    Article  PubMed  Google Scholar 

  • Gilger EA, Groben VJ, Hinds PS (2002) Osteosarcoma nursing care guidelines: a tool to enhance the nursing care of children and adolescents enrolled on a medical research protocol. Journal of Pediatric Oncology Nursing 19(5):172–181

    Article  PubMed  Google Scholar 

  • Ginsberg J P, Rai SN, Carlson CA, Meadows AT, Hinds PS, Spearing EM, Zhang L, Callaway L, Neel MD, Rao BN, Marchese VG (2007) A comparative analysis of functional outcomes in adolescents and young adults with lower-extremity bone sarcoma. Pediatric Blood & Cancer 49(7):964–969

    Article  Google Scholar 

  • Grimer RJ (2005) Surgical options for children with osteosar-coma. The Lancet Oncology 6(2):85–92

    Article  PubMed  Google Scholar 

  • Hesseling PB, Hough SF, Nel ED, van Riet FA, Beneke T, Wessels G (1998) Bone mineral density in long-term survivors of childhood cancer. International Journal of Cancer. Supplement 11:44–47

    CAS  Google Scholar 

  • Hillman A, Gosheger G, Hoffman C, Ozaki T, Winkelmann W (2000) Rotationplasty: surgical treatment modality after failed limb salvage procedure. Archives of Orthopaedic and Trauma Surgery 120(10):555–558

    Article  Google Scholar 

  • Hopewell JW (2003) Radiation-therapy effects on bone density. Medical and Pediatric Oncology 41(3):208–211

    Article  PubMed  Google Scholar 

  • Hopyan S, Tan JW, Graham HK, Torode IP (2006) Function and upright time following limb salvage, amputation, and rota-tionplasty for pediatric sarcoma of bone. Journal of Pedi-atric Orthopedics 26(3):405–408

    Article  Google Scholar 

  • Hosalkar HS, Dormans JP (2004) Limb sparing surgery for pediatric musculoskeletal tumors. Pediatric Blood & Cancer 42(4):295–310

    Article  Google Scholar 

  • Karimova EJ, Kaste S (2007) MR imaging of osteonecrosis of the knee in children with acute lymphoblastic leukemia. Pediatric Radiology 37:1140–1146

    Article  PubMed  Google Scholar 

  • Kaste SC (2008) Skeletal toxicities of treatment in children with cancer. Pediatric Blood & Cancer 50(2 Suppl):469–473

    Article  Google Scholar 

  • Kaste SC, Metzger ML, Minhas A, Xiong Z, Rai SN, Ness KK, Hudson MM (2009) Pediatric Hodgkin lymphoma survivors at negligible risk for significant bone mineral density deficits. Pediatric Blood & Cancer 52(4):516–521

    Article  Google Scholar 

  • Kotz R (1997) Rotationplasty. Seminars in Surgical Oncology 13(1):34–40

    Article  PubMed  CAS  Google Scholar 

  • Kumta SM, Cheng JC, Li CK, Griffith JF, Chow LT, Quintos AD (2002) Scope and limitations of limb-sparing surgery in childhood sarcomas. Journal of Pediatric Orthopedics 22 (2):244–248

    PubMed  Google Scholar 

  • Lane JM, Christ GH, Khan SN, Backus SI (2001) Rehabilitation for limb salvage patients: kinesiological parameters and psychological assessment. Cancer 92(4):1013–1019

    Article  PubMed  CAS  Google Scholar 

  • Marker DR, Thornsten M, Seyler M, McGrath S, Delanois R, Ulrich S, Mont M (2008) Treatment of early stage osteone-crosis of the femoral head. The Journal of Bone and Joint Surgery 90(Suppl 4):175–187

    PubMed  Google Scholar 

  • Mattano L (2003) The skeletal remains: porosis and necrosis of bone in the marrow transplantation setting. Pediatric Transplantation 7(Suppl 3):71–75

    Article  PubMed  Google Scholar 

  • Mattano L, Harland N, Sather M, Trigg M, Nachman J (2000) Osteonecrosis as a complication of treating acutelymphoblastic leukemia in children: a report from the children's cancer group. Journal of Clinical Oncology 18(18):3262–3272

    PubMed  Google Scholar 

  • Nagarajan R, Neglia J P, Clohisy DR, Robison LL (2002) Limb salvage and amputation in survivors of paediatric lower-extremity bone tumors: what are the long term implications? Journal of Clinical Oncology 20(20):4493–4501

    Article  PubMed  Google Scholar 

  • Nagarajan R, Neglia J P, Clohisy DR, Yasui Y, Greenberg M, Hudson M, Zevon MA, Tersak JM, Ablin A, Robison LL (2003) Education, employment, insurance, and marital status among 694 survivors of pediatric lower extremity bone tumors: a report from the childhood cancer survivor study. Cancer 97(10):2554–2564

    Article  PubMed  Google Scholar 

  • Nagarajan R, Clohisy DR, Neglia JP, Yasui Y, Mitby PA, Sklar C, Finklestein JZ, Greenberg M, Reaman GH, Zeltzer L, Robi-son LL (2004) Function and quality-of-life of survivors of pelvic and lower extremity osteosarcoma and Ewing's sarcoma: the Childhood Cancer Survivor Study. British Journal of Cancer 91(11):1858–1865

    Article  PubMed  CAS  Google Scholar 

  • Niinimake R, Harila-Saari A, Jartti A, Seuri R, Riikonen P, Paakko P, Mottonen M, Lanning M (2007) High body mass index increases the risk of osteonecrosis in children with acute lymphoblastic leukemia. Journal of Clinical Oncology 25(12):1498–1504

    Article  Google Scholar 

  • Nysom K, Holm K, Hertz H, Muller J, Fleischer Michaelsen K, Molgaard C (2001) Bone mass after treatment for acute lymphoblastic leukaemia in childhood. Journal of Clinical Oncology 19(11):2970–2971

    PubMed  CAS  Google Scholar 

  • Odame I, Duckworth J, Talsman D, Beaumont L, Furlong W, Webber C, Barr R (2006) Osteopenia, physical activity and health-related quality of life in survivors of brain tumors treated in childhood. Pediatric Blood & Cancer 46:357–362

    Article  Google Scholar 

  • Rao BN, Rodriguez-Galindo C (2003) Local control in childhood extremity sarcomas: salvaging limbs and sparing function. Medical and Pediatric Oncology 41(6):584–587

    Article  PubMed  Google Scholar 

  • Refaat Y, Gunnoe J, Hornicek FJ, Mankin HJ (2002) Comparison of quality of life after amputation or limb salvage. Clinical Orthopaedics and Related Research 397:298–305

    Article  PubMed  Google Scholar 

  • Relling M V, Yang W, Das S, Cook E, Rosner G, Neel M, Scott H, Ribeiro R, Sandlund J, Pui CH, Kaste S (2004) Pharmacogenetic risk factors for osteonecrosis of the hip among children with leukemia. Journal of Clinical Oncology 22(19):3930–3936

    Article  PubMed  Google Scholar 

  • Renard AJ, Veth RP, Schreuder HW, van Loon CJ, Koops HS, van Horn JR (2000) Function and complications after ablative and limb-salvage therapy in lower extremity sarcoma of the bone. Journal of Surgical Oncology 73(4):198–205

    Article  PubMed  CAS  Google Scholar 

  • Sala A, Mattano L, Barr R (2007) Osteonecrosis in children and adolescents with cancer — an adverse effect of systemic therapy. European Journal of Cancer 43:683–689

    Article  PubMed  Google Scholar 

  • Sluga M, Windhager R, Lang S, Heinzl H, Bielack S, Kotz R (1999) Local and systemic control after ablative and limb sparing surgery in patients with osteosarcoma. Clinical Orthopaedics and Related Research 358:120–127

    Article  PubMed  Google Scholar 

  • Socie G, Selimi F, Sedel L, Frija J, Deverqie A, Esperou Bour-deau H, Ribaud P, Gluckman E (1994) Avascular necrosis of bone after allogeneic bone marrow transplantation: clinical findings, incidence and risk factors. British Journal of Haematology 86:624–628

    Article  PubMed  CAS  Google Scholar 

  • Stauss A, Su J, Dalton V, Gelber R, Sallan S, Silverman L (2001) Bone morbidity in children treated for acute lymphoblastic leukemia. Journal of Clinical Oncology 19(12):3066–3072

    Google Scholar 

  • van der Sluis IM, van den Heuvel-Eibrink MM (2008) Osteoporosis in children with cancer. Pediatric Blood & Cancer 50(2 Suppl):474–478

    Article  Google Scholar 

  • van der Sluis IM, van den Heuvel-Eibrink MM, Hahlen K, Krenning E P, de Muinck Keizer-Schrama SM (2002) Altered bone mineral density and body composition, and increased fracture risk in childhood acute lymphoblastic leukemia. Journal of Pediatrics 141(2):204–240

    Article  PubMed  Google Scholar 

  • Wasilewski-Masker K, Kaste SC, Hudson MM, Esiashvili N, Mattano LA, Meacham LR (2008) Bone mineral density deficits in survivors of childhood cancer: long-term follow-up guidelines and review of the literature. Pediatrics 121(3):e705–e713

    Article  PubMed  Google Scholar 

  • Weis LD (1999) The success of limb-salvage surgery in the adolescent patient with osteogenic sarcoma. Adolescent Medicine 10(3):451–458, xii

    PubMed  CAS  Google Scholar 

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Tomlinson, D., Zupanec, S. (2010). Musculoskeletal System. In: Tomlinson, D., Kline, N.E. (eds) Pediatric Oncology Nursing. Pediatric Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-87984-8_24

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  • DOI: https://doi.org/10.1007/978-3-540-87984-8_24

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-87983-1

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