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Binding Site Barrier

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Encyclopedia of Radiation Oncology

Definition

Phenomenon used to describe the differential binding of antibody to antigen immediately outside of a vascular wall (vascularized tumor) or in the periphery of a tumor (preangiogenic tumor). The differential binding is thought to be due to very high affinities of the antibody-antigen complex and due to nonspecific binding of normal tissue. Antibodies, therefore, do not move quickly “off” of the antigen and therefore do not penetrate into the tumor to any meaningful extent.

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Targeted Radioimmunotherapy

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Authors and Affiliations

  1. Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, UW Hospital and Clinics, 215 N. 28th Avenue, 54401, Madison, WI, USA

    Dr. Tod W. Speer

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  1. Dr. Tod W. Speer
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Correspondence to Tod W. Speer .

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Editors and Affiliations

  1. Distinguished University Professor, Hylda Cohn/American Cancer Professor Of Clinical Oncology, Professor of Radiation Oncology, Drexel University College of Medicine, MS 200, 216 North Broad St., Philadelphia, PA, 19102, USA

    Luther W. Brady MD

  2. Department of Radiation Oncology, Wake Forest University School of Medicine, Winston-Salem, NC, 27157-0001, USA

    Theodore E. Yaeger MD

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© 2013 Springer-Verlag Berlin Heidelberg

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Speer, T.W. (2013). Binding Site Barrier. In: Brady, L.W., Yaeger, T.E. (eds) Encyclopedia of Radiation Oncology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85516-3_676

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  • DOI: https://doi.org/10.1007/978-3-540-85516-3_676

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-85513-2

  • Online ISBN: 978-3-540-85516-3

  • eBook Packages: MedicineReference Module Medicine

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