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DW-MRI Assessment of Treatment Response to Minimally Invasive Therapy

  • Chapter
Diffusion-Weighted MR Imaging

Part of the book series: Medical Radiology ((Med Radiol Diagn Imaging))

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Summary

Minimally invasive interventional oncology therapies consist of various therapeutic catheter-based (such as transcatheter arterial chemoembolization) and percutaneous ablative approaches (such as radiofrequency ablation) using imaging for guidance to treat solid malignancies, and have recently emerged as a major therapeutic alternative against cancer. Monitoring tumour response to these therapies is currently performed by measuring changes in tumour size with contrast-enhanced computed tomography (CT) or magnetic resonance (MR) imaging. However, morphological tumour changes occur relatively late in the course of therapy, while functional changes can occur prior to tumour size changes. Since minimally invasive therapies cause tumour cell membrane destruction and/or obliteration of tumour micro vessels, with subsequent alterations in the microscopic movement of water molecules, DW-MRI seems to be a potential non-invasive tool for measuring early functional tumour response to such therapies.

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Author information

Authors and Affiliations

  1. The Russell H Morgan Department of Radiology and Radiological Sciences, The Johns Hopkins Hospital, Baltimore, MD, 21287, USA

    Eleni Liapi & Ihab R. Kamel

Authors
  1. Eleni Liapi
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  2. Ihab R. Kamel
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Editor information

Editors and Affiliations

  1. Royal Marsden NHS Foundation Trust, Department of Radiology, Downs Road, Sutton, SM2 5PT, United Kingdom

    D. M. Koh

  2. Department of Diagnostic, Interventional and Paediatric Radiology, Universitätsspital Bern Inselspital, Freiburgstr. 10, Bern, 3010, Switzerland

    H. C. Thoeny

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© 2010 Springer-Verlag Berlin Heidelberg

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Liapi, E., Kamel, I.R. (2010). DW-MRI Assessment of Treatment Response to Minimally Invasive Therapy. In: Koh, D.M., Thoeny, H.C. (eds) Diffusion-Weighted MR Imaging. Medical Radiology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-78576-7_11

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  • DOI: https://doi.org/10.1007/978-3-540-78576-7_11

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-78575-0

  • Online ISBN: 978-3-540-78576-7

  • eBook Packages: MedicineMedicine (R0)

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