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Portal hypertension

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Abstract

Aristoteles (384-322 BC) first described the portal vein within the venous system. Herophilos (ca. 300-250 BC) was the first to recognize the portal vein system and its importance as the discharge zone for all resorbent intestinal veins. (s. pp. 6, 7) · A description of the portal vein system with its intrahepatic branches and separate bloodstream was given by Galenus (129–199 AD). (s. p. 8) · The, independence of the portal vein circulation from the overall blood circulation was demonstrated by F. Glisson (1597–1677). (s. p. 10)

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References

  1. Abecasis, R., Kravetz, D., Fassio, E., Ameigeiras, B., Garcia, D., Isla, R., Landeira, G., Dominguez, N., Romero, G., Argonz, J., Terg, R.: Nadolol plus spironolactone in the prophylaxis of first variceal bleed in nonascitic cirrhotic patients: a preliminary study. Hepatology 2003; 37: 359–365.

    Article  PubMed  CAS  Google Scholar 

  2. Alexopoulou, A., Papanikolopoulos, K., Thanos, L., Dourakis, S.P.: Aneurysmal dilatation of the portal vein: A rare cause of portal hypertension (case report). Scand. J. Gastroenterol. 2005; 40: 233–235

    Article  PubMed  Google Scholar 

  3. Aithal, G.P., Alabdi, B.J., Rose, J.D.G., James, O.F.W., Hudson, M.: Portal hypertension secondary to arterioportal fistulae: two unusual cases. Liver 1999; 19: 343–347

    Article  PubMed  CAS  Google Scholar 

  4. Albillos, A., Colombato, L.A., Enriquez, R., Oi Cheng Ng, Sikuler, E., Groszmann, R.J.: Sequence of morphological and hemodynamic changes of gastric microvessels in portal hypertension. Gastroenterology 1992; 102: 2066–2070

    PubMed  CAS  Google Scholar 

  5. Alvarez, D., Mastai, R., Lennie, A., Soifer, G., Levi, D., Terg, R.: Noninvasive measurement of portal venous blood flow in patients with cirrhosis: effects of physiological and pharmacological stimuli. Dig. Dis. Sci. 1991; 36: 82–86

    Article  PubMed  CAS  Google Scholar 

  6. Aprile, L.R.O., Meneghelli, U.G., Martinelli, A.L.C., Monteiro, C.R.: Gastric motility in patients with presinusoidal portal hypertension. Amer. J. Gastroenterol. 2002; 97: 3038–3044

    Article  Google Scholar 

  7. Banares, Y., Moitinho, E., Matilla, A., Garcia-Pagan, J.C., Lampreave, J.L., Piera, C., Abraldes, J.G., de Diego, A., Albillos, A., Bosch, J.: Randomized comparison of long-term carvedilol and propranolol administration in the treatment of portal hypertension in cirrhosis. Hepatology 2002; 36: 1367–1373

    PubMed  CAS  Google Scholar 

  8. Banti, G.: Splenomegalie mit Leberzirrhose. Beitr. Path. Anat. Allg. Path. 1889; 24: 21–33.

    Google Scholar 

  9. Bayraktar, Y., Balkanci, F., Kayhan, B., Özenc, A., Arslan, S., Telatar, H.: Bile duct varices or “pseudo-cholangiocarcinoma sign” in portal hypertension due to cavernous transformation of the portal vein. Amer. J. Gastroenterol. 1992; 87: 1801–1806

    CAS  Google Scholar 

  10. Bayraktar, Y., Balkanci, F., Kansu, E., Dundar, S., Uzunalimoglu, B., Kayhan, B., Telatar, H., Gurakar, A. van Thiel, D.H.: Cavernous transformation of the portal vein: a common manifestation of Behcet’s disease. Amer. J. Gastroenterol. 1995; 90: 1476–1479

    CAS  Google Scholar 

  11. Benoit, J.N., Granger, D.N.: Splanchnic haemodynamics in chronic portal hypertension. Semin. Liver Dis. 1986; 6: 287–298

    Article  PubMed  CAS  Google Scholar 

  12. Bini, E.J., Lascarides, C.E., Micale, P.L., Weinshel, E.H.: Mucosal abnormalities of the colon in patients with portal hypertension: an endoscopic study. Gastrointest. Endosc. 2000; 52: 511–516

    Article  PubMed  CAS  Google Scholar 

  13. Blendis, L., Smith, P., Lawrie, B., Stephens, M.R., Evans, W.D.: Portal hypertension in vinylchloride monomer workers: A hemodynamic study. Gastroenterology 1978; 75: 206–211

    PubMed  CAS  Google Scholar 

  14. Bosch, J., Abraldes, J.G., Groszmann, R.: Current management of portal hypertension. J. Hepatol. 2003; 38 (Suppl.) 54–68

    Article  Google Scholar 

  15. Boyer, T.D., Haskal, Z.J.: The role of transjugular intrahepatic shunt in the management of portal hypertension. Hepatology 2005; 41: 386–400

    Article  PubMed  Google Scholar 

  16. Braun, S.D., Newman, G.E., Dunnick, N.R.: Digital splenoportography. Amer. J. Roentgenol. 1985; 144: 1003–1004

    CAS  Google Scholar 

  17. Bruet, A., Fingerhut, A., Eugene, C., Fendler, J.P.: Varices intestinales et hypertension portale. Gastroenterol. Clin. Biol. 1984; 8: 725–732

    CAS  Google Scholar 

  18. Burcharth, F., Bertheussen, K.: The influence of posture, Valsalva manoeuvre and coughing on portal hypertension in cirrhosis. Scand. J. Clin. Lab. Invest. 1987; 39: 665–669

    Article  Google Scholar 

  19. Chandra, R., Kapoor, D., Tharakan, A., Chaudhary, A., Sarin, S.K.: Portal biliopathy. J Gastroenterol. Hepatol. 2001; 16: 1086–1092

    Article  PubMed  CAS  Google Scholar 

  20. Chawla, Y., Dilawari, J.B.: Anorectal varices—their frequency in cirrhotic and non-cirrhotic portal hypertension. Gut 1991; 32: 309–311

    Article  PubMed  CAS  Google Scholar 

  21. Conn, H.O.: Portal hypertension: history and pathogenesis. Gastroenterol. Internal. 1992; 5: 181–185

    Google Scholar 

  22. D’Amico, G., Montalbano, L., Traina, M., Pisa, R., Menozzi, M., Spano, C., Pagliaro, L.: Natural history of congestive gastropathy in cirrhosis. Gastroenterology 1990; 99: 1558–1564

    PubMed  Google Scholar 

  23. Debernardi-Venon, W., Bandi, J.C., Garcia-Pagan, J.C., Moitinho, E., Andreu, V., Real, M., Escorsell, A., Montanya, X., Bosch, J.: CO2 wedged hepatic venography in the evaluation of portal hypertension. Gut 2000; 46: 856–860

    Article  PubMed  CAS  Google Scholar 

  24. DeCoux, R.E., jr., Achord, J.L.: Portal hypertension in Felty’s syndrome. Amer. J. Gastroenterol. 1980; 73: 315–318

    Google Scholar 

  25. Drouhin, F., Fischer, D., Vadrot, J., Denis, J., Johanet, C., Abuaf, N., Feldmann, G., Labayle, D.: Hypertension portale idiopathique associée à une collagénose proche du lupus érythémateux disseminé. Gastroenterol. Clin. Biol. 1989; 13: 829–833

    PubMed  CAS  Google Scholar 

  26. Dubois, A., Dauzat, M., Pignodel, Ch., Pomier-Layrargues, G., Marty-Double, Ch., Lopez, F.-M., Janbon, C.: Portal hypertension in lymphoproliferative and myeloproliferative disorders: hemodynamic and histological correlations. Hepatology 1993; 17: 246–250

    PubMed  CAS  Google Scholar 

  27. Ehrle, U.B., Müller, M.K., Singer, M.V.: Downhill-Varizen im Ösophagus. Ursachen und klinische Bedeutung. Dtsch. Med. Wschr. 1992; 117: 705–709

    PubMed  CAS  Google Scholar 

  28. Eyres, K.S., Kantharia, B., Magides, A.D., Ali, H.H., MacDonald, R.C.: Portal hypertension due to hepatosplenic schistosomiasis: a case report and review of the literature. Brit. J. Clin. Pract. 1991; 45: 146–147

    PubMed  CAS  Google Scholar 

  29. Felson, B., Lessure, A.P.: “Downhill” varices of the esophagus. Dis. Chest. 1964; 46: 740–746

    Article  PubMed  CAS  Google Scholar 

  30. Fraser-Hill, M.A., Atri, M., Bret, P.M., Aldis, A.E., Illescas, F.F., Herschorn, S.D.: Intrahepatic portal venous system: variations demonstrated with duplex and color doppler US. Radiology 1990; 177: 523–526

    PubMed  CAS  Google Scholar 

  31. Futagawa, S., Fukazawa, M., Horisawa, M., Musha, H., Ito, T., Sugiura, M., Kameda, H., Okuda, K.: Portographic liver changes in idiopathic noncirrhotic portal hypertension. Amer. J. Roentgenol. 1980; 134: 917–923

    CAS  Google Scholar 

  32. Gabata, T., Matsui, O., Kadoya, M., Yoshikawa, J., Ueda, K., Nobata, K., Kawamori, Y., Takashima, T.: Gallbladder varices: demonstration of direct communication to intrahepatic portal veins by color Doppler sonography and CT during arterial portography. Abdom. Imag. 1997; 22: 82–84

    Article  CAS  Google Scholar 

  33. Gatta, A., Sacerdoti, D., Bolognesi, M., Merkel, C.: Portal hypertension: state of the art. Ital. J. Gastroenterol. Hepatol. 1999; 31: 326–345

    CAS  Google Scholar 

  34. Geraghty, J.G., Angerson, W.J., Carter, D.C.: Erosive gastritis and portal hypertension. HPB Surgery 1992; 6: 19–22

    Article  PubMed  CAS  Google Scholar 

  35. Gertsch, P., Fischer, G., Kleber, G., Wheatley, A.M., Geigenberger, G., Sauerbruch, T.: Manometry of esophageal varices: comparison of an endoscopic balloon technique with needle puncture. Gastroenterology 1993; 105: 1159–1166

    PubMed  CAS  Google Scholar 

  36. Gibson, P.R., Gibson, R.N., Ditchfield, M.R., Donlan, J.D.: Splenomegaly — an insensitive sign of portal hypertension. Aust. N. Z. J. Med. 1990; 20: 771–774

    PubMed  CAS  Google Scholar 

  37. Gibson, P.R., Gibson, R.N., Ditchfield, M.R., Donlan, J.D.: A comparison of duplex Doppler sonography of the ligamentum teres and portal vein with endoscopic demonstration of gastroesophageal varices in patients with chronic liver disease or portal hypertension or both. J. Ultrasound Med. 1992; 11: 327–331

    PubMed  CAS  Google Scholar 

  38. Gilbert, A., Villaret, M.: Contribution to the study of the syndrome of portal hypertension. Compt. Rend. Soc. Biol. 1906; 60: 820–823

    Google Scholar 

  39. Glynn, M.J.: Isolated splenic vein thrombosis. Arch. Surg. 1986; 121: 723–725

    PubMed  CAS  Google Scholar 

  40. Goenka, M.K., Kochhar, R., Nagi, B., Mehta, S.K.: Rectosigmoid varices and other mucosal changes in patients with portal hypertension. Amer. J. Gastroenterol. 1991; 86: 1185–1189

    CAS  Google Scholar 

  41. Goyal, A.K., Pokharna, D.S., Sharma, S.K.: Ultrasonic measurements of portal vasculature in diagnosis of portal hypertension. J. Ultrasound Med. 1990; 9: 45–48

    PubMed  CAS  Google Scholar 

  42. Groszman, R.J.: Hyperdynamic circulation of liver disease 40 years later: pathophysiology and clinical consequences. Hepatology 1994; 20: 1359–1363

    Google Scholar 

  43. Gudjonsson, H., Zeiler, D., Gamelli, R.L., Kay, M.D.: Colonic varices. Report of an unusual case diagnosed by radionuclide scanning, with review of the literature. Gastroenterology 1986; 91: 1543–1547

    PubMed  CAS  Google Scholar 

  44. Guerrero-Hernandez, I., Weimersheimer Sandoval, M., Lopez Mendez, E., Hernandez Calleros, J., Tapia, A.R., Tiribe, M.: Biliary structure caused by portal biliopathy. Case report and literature review. Ann-Hepatol. 2005; 4: 286–288

    PubMed  Google Scholar 

  45. Hadengue, A., Benhayoun, M.K., Lebrec, D., Benhamou, J.-P.: Pulmonary hypertension complicating portal hypertension:prevalence and relation to splanchnic hemodynamics. Gastroenterology 1991; 100: 520–528

    PubMed  CAS  Google Scholar 

  46. Hartleb, M., Michielsen, P.P., Dziurkowska-Marek, A.: The role of nitric oxide in portal hypertensive systemic and portal vascular pathology. Acta Gastroenterol. Belg. 1997; 60: 222–232

    PubMed  CAS  Google Scholar 

  47. Hase, R., Hirano, S., Kondo, S., Okushiba, S., Morikawa, T., Katoh, H.: Long-term efficacy of distal, splenorenal shunt with splenopancreatic and gastric disconnection for esophagogastric varices in patients with idiopathic portal hypertension. World J. Surg. 2005; 29: 1034–1037

    Article  PubMed  Google Scholar 

  48. Hashimoto, N., Ohyanagi, H.: Effect of acute portal hypertension on gut mucosa. Hepato-Gastroenterol. 2002; 49: 1567–1570

    Google Scholar 

  49. Hashizume, M., Sugimachi, K.: Classifikation of gastric lesions associated with portal hypertension. J. Gastroenterol. Hepatol. 1995; 10: 339–343

    Article  PubMed  CAS  Google Scholar 

  50. Hernandez-Guerra, M., Garcia-Pagan J.C., Turnes, J., Bellot, P., Deulofeu, R., Abraldes, J.G., Bosch, J.: Ascorbic acid improves the intrahepatic endothelial dysfunction of patients with cirrhosis and portal hypertension. Hepatology 2006; 43: 485–491

    Article  PubMed  CAS  Google Scholar 

  51. Hosking, S.W., Smart, H.L., Johnson, A.G., Triger, D.R.: Anorectal varices. haemorrhoids, and portal hyertension. Lancet 1989/I: 349–352

    Article  Google Scholar 

  52. Hüppe, D., Jäger, D., Tromm, A., Tunn, S., Barmeyer, J., May, B.: Einfluß von Molsidomin auf die portale und kardiale Hämodynamik bei Leberzirrhose. Dtsch. Med. Wschr. 1991; 116: 841–845

    PubMed  Google Scholar 

  53. Ibukuro, K., Tsukiyama, T., Mori, K., Inoue, Y.: Veins of Retzius at CT during arterial portography: anatomy and clinical importance. Radiology 1998; 209: 793–800

    PubMed  CAS  Google Scholar 

  54. Inagaki, H., Nonami, T., Kawagoe, T., Miwa, T., Hosono, J., Kurokawa, T., Harada, A., Nakao, A., Takagi, H., Suzuki, H., Sakamoto, J.: Idiopathic portal hypertension associated with systemic lupus erythematosus. J. Gastroenterol. 2000; 35: 235–239

    Article  PubMed  CAS  Google Scholar 

  55. Itzchak, Y., Glickman, M.G.: Duodenal varices in extrahepatic portal obstruction. Radiology 1977; 124: 619–624

    PubMed  CAS  Google Scholar 

  56. Jassar, P., Jaramillo, M., Numez, D.A.: Base of tongue varices associated with portal hypertension. Postgrad. Med. J. 2000; 76: 576–577.

    Article  PubMed  CAS  Google Scholar 

  57. Kapoor, D., Redhead, D.N., Hayes, P.C., Webb, D.J., Jalan, R.: Systemic and regional changes in plasma endothelin following transient increase in portal pressure. Liver Transplant. 2003; 9: 32–39.

    Article  Google Scholar 

  58. Kim, M.J., Mitchell, D.G., Ito, K.: Portosystemic collaterals of the upper abdomen: review of anatomy and demonstration on MR imaging. Abdom. Imag 2000; 25: 462–470

    Article  CAS  Google Scholar 

  59. Kim, S., Chew, W.S.: Choledochal varices. Amer. J. Roentgenol. 1998; 150: 578–580

    Google Scholar 

  60. Klein, C.-P.: Spironolacton in der Behandlung der portalen Hypertonie bei Leberzirrhose. Dtsch. Med. Wschr. 1985; 110: 1774–1776

    PubMed  CAS  Google Scholar 

  61. Kotfila, R., Trudeau, W.: Extraoesophageal varices. Dig. Dis. 1998; 16: 232–241

    Article  PubMed  CAS  Google Scholar 

  62. Kozarek, R.A., Botoman, V.A., Bredfeldt, J.E., Roach, J.M., Patterson, D.J. Ball, T.J.: Portal colopathy: prospective study of colonoscopy in patients with portal hypertension. Gastroenterology 1991; 101: 1192–1197

    PubMed  CAS  Google Scholar 

  63. Kuntz, H.D., Freyberger, H., May, B.: Portale Hypertonie ohne Leberzirrhose. Zur Differentialdiagnose, Pathogenese und Klinik der post-traumatischen Pfortaderthrombose. Münch. Med. Wschr. 1985; 127: 97–99

    Google Scholar 

  64. LaBreque, D.R.: Portal hypertension. Clin. Liver Dis. 1997; 1: 1–24

    Article  Google Scholar 

  65. Lasierra, J., Barrao, F., Cena, G., Aza, M.J., Morandeira, M.J., Barrao, M.E., Gonzalez-Gallego, J.: Changes of the fibrinolytic system in liver dysfunction: role of portal hypertension. Thromb. Res. 1992; 67: 15–21

    Article  PubMed  CAS  Google Scholar 

  66. Lebrec, D., Benhamou, J.-P.: Noncirrhotic intrahepatic portal hypertension. Semin. Liver Dis. 1986; 6: 332–340

    Article  PubMed  CAS  Google Scholar 

  67. Lebrec, D., Moreau, R.: Pathogenesis of portal hypertension. Eur. J. Gastroenterol. Hepatol. 2001; 13: 309–311

    Article  PubMed  CAS  Google Scholar 

  68. Lee, S.S., Hadengue, A., Moreau, R., Sayegh, R., Hillon, P., Lebrec, D.: Postprandial hemodynamic response in patients with cirrhosis. Hepatology 1988; 8: 647–651

    Article  PubMed  CAS  Google Scholar 

  69. Leeuwen, van, D.J., Howe, S.C., Scheuer P.J., Sherlock, S.: Portal hypertension in chronic hepatitis: relationship to morphological changes. Gut 1990; 31: 339–343

    Article  PubMed  Google Scholar 

  70. Leger, L., Lemaigre, G., Prémont, M., Salmon, R., Klioua, Z., Battesti, J.-P.: Hypertension portale au cours de la sarcoidose. Trois observations dont une avec foie fibreux et hépatome malin à stroma osseux. Nouv. Presse Méd. 1980; 9: 1021–1024

    PubMed  CAS  Google Scholar 

  71. Lenthall, R., Kane, P.A., Heaton, N.D., Karani, J.B.: Segmental portal hypertension due to splenic obstruction: imaging findings and diagnostic pitfalls in four cases. Clin. Radiol. 1999; 54: 540–544

    Article  PubMed  CAS  Google Scholar 

  72. Limberg, B.: Duplexsonographische Diagnose der portalen Hypertension bei Leberzirrhose. Einfluß einer standardisierten Testmahlzeit auf die portale Hämodynamik. Dtsch. Med. Wschr. 1991; 116: 1384–1387

    PubMed  CAS  Google Scholar 

  73. Liu, G.-L., Huang, Y.-T.: Portal hypertension caused by biliary cirrhosis. Gastroenterol. Jap. 1991; 26 (Suppl. 3) 22–26.

    Google Scholar 

  74. Lorenz, R., Brauer, M., Classen, M., Tornieporth, N., Becker, K.: Idiopathic portal hypertension in a renal transplant patient after long-term azathioprine therapy. Clin. Investig. 1992, 70: 152–155

    Article  PubMed  CAS  Google Scholar 

  75. Lukie, B.E., Card, R.T.: Portal hypertension complicating myelofibrosis: reversal following splenectomy. Canad Med. Ass. J. 1977; 117: 771–772

    PubMed  CAS  Google Scholar 

  76. Madsen, M.S., Petersen, T.H., Sommer, H.: Segmental portal hypertension. Ann. Surg. 1986; 204: 72–77

    Article  PubMed  CAS  Google Scholar 

  77. Malde, H., Nagral, A., Shah, P., Joshi, M.S., Bhatia, S.J., Abraham, P.: Detection of rectal and pararectal varices in patients with portal hypertension: efficacy of transvaginal sonography. Amer. J. Roentgenol. 1993; 161: 335–337

    CAS  Google Scholar 

  78. Marchal, G.J.F., van Holsbeek, M., Tshibwabwa-Ntumba, E., Goddeeris, P.G., Fvery, J., Oyen, R.H., Adisoejoso, B., Baert, A.L., van Steenbergen, W.: Dilatation of the cystic veins in portal hypertension: sonographic demonstration. Radiology 1985; 154: 187–189

    PubMed  CAS  Google Scholar 

  79. Markowitz, A.J., Chen, Y.-T., Muenzer, J., Delbuono, E.A., Lucey, M.R.: A man with type III glycogenosis associated with cirrhosis and portal hypertension. Gastroenterology 1993; 105: 1882–1885

    PubMed  CAS  Google Scholar 

  80. Matsumoto, A., Kitamoto, M., Imamura M., Nakanishi, T., Ono, C., Ito, K., Kajiyama, G.: Three-dimensional portography using multislice helical CT is clinically useful for management of gastric fundus varices. Amer. J. Roentgenol. 2001; 176: 899–905.

    CAS  Google Scholar 

  81. McCormick, P.A., Burroughs, A.K.: Hemodynamic evaluation of portal hypertension. Hepato-Gastroenterol. 1990; 37: 546–550

    CAS  Google Scholar 

  82. Meran, J., Creutzig, A., Specht, S., Schürmeyer, T., Brunner, G., Ranke, C., Fabel, H.: Portale Hypertension und chronische Arsen in toxikation. Wien. Med. Wschr. 1989; 139: 580–584

    PubMed  CAS  Google Scholar 

  83. Merkel, C., Bolognesi, M., Bellon, St., Sacerdoti, D., Bianco, S., Amodio, P., Gatta, A.: Long-term follow-up study of adult patients with non-cirrhotic obstruction of the portal system: comparison with cirrhotic patients. J. Hepatol. 1992; 15: 299–303

    Article  PubMed  CAS  Google Scholar 

  84. Meßmann, H., Holstege, A., Schölmerich, J.: Lebervenenverschlußdruckmessung. Indikation, Technik und Befunde. Dtsch. Med. Wschr. 1994; 119: 1245–1247

    PubMed  Google Scholar 

  85. Moriyasu, F., Nishida, O., Ban, N., Nakamura, T., Sakai, M., Miyake, T., Uchino, H.: “Congestion index” of the portal vein. Amer. J. Roentgenol. 1986; 146: 735–739

    CAS  Google Scholar 

  86. Naber, A.H.J., van Haelst, U., Yap, S.H.: Nodular regenerative hyperplasia of the liver an important cause of portal hypertension in noncirrhotic patients. J. Hepatol. 1991; 12: 94–99.

    Article  PubMed  CAS  Google Scholar 

  87. Nakanuma, Y., Ohta, G., Kurumaya, H., Tanino, M., Doishita, K., Takayanagi, N., Rin, S.: Pathological, study on livers with noncirrhotic portal hypertension and portal venous thromboembolic occlusion: report of seven autopsy cases. Amer. J. Gastroenterol. 1984; 79: 782–789

    CAS  Google Scholar 

  88. Navasa, M., Garcia-Pagan, J.C., Bosch, J., Riera, J.R., Banares, R., Mas, A., Bruguera, M., Rodes, J.: Portal hypertension in acute liver failure. Gut 1992; 33: 965–968

    Article  PubMed  CAS  Google Scholar 

  89. Nevens, F., Fevery, J., van Steenbergen, W., Sciot, R., Desmet, V., de Groote, J.: Arsenic and non-cirrhotic portal hypertension. J. Hepatol. 1990; 11: 80–85

    Article  PubMed  CAS  Google Scholar 

  90. Nevens, F., Bustami, R., Scheys, I., Lesaffre, E., Fevery J.: Variceal pressure is a factor predicting the risk of a first variceal bleeding. A prospective cohort study in cirrhotic patients. Hepatology 1998; 27: 15–19

    Article  PubMed  CAS  Google Scholar 

  91. O’Connor, M.K., MacMathuna, P., Keeling, P.W.N.: Hepatic arterial and portal venous components of liver blood flow: a dynamic scinitigraphic study. J. Nucl. Med. 1988; 29: 466–472

    Google Scholar 

  92. Odievre, M., Pigé, G., Alagille, D.: Congenital abnormalities associated with extrahepatic portal hypertension. Arch. Dis. Childh. 1977; 52: 383–385

    Article  PubMed  CAS  Google Scholar 

  93. Oelsner, D.H., Caldwell, S.H., Coles, M., Driscoll, C.J.: Subumbilical midline vascularity of the abdominal wall in portal hypertension observed at laparoscopy. Gastrointest. Endosc. 1988; 47: 388–390

    Article  Google Scholar 

  94. Okuda, K., Kono, K., Ohnishi, K., Kimura, K., Omata, M., Koen, H., Nakajima, Y., Musha, H., Hirashima, T., Takashi, M., Takayasu, K.: Clinical study of eighty-six cases of idiopathic portal hypertension and comparison with cirrhosis with splenomegaly. Gastroenterology 1984; 86: 600–610

    PubMed  CAS  Google Scholar 

  95. Okuda, K., Ohnishi, K., Kimura, K., Matsutani, S., Sumida, M., Goto, N., Musha, H., Takashi, M., Suzuki, N., Shinagawa, T., Suzuki, N., Ohtsuki, T., Arakawa, M., Nakashima, T.: Incidence of portal vein thrombosis in liver cirrhosis. An angiographic study in 708 patients. Gastroenterology 1985; 89: 279–286

    PubMed  CAS  Google Scholar 

  96. Orozco, H., Mercado, M.A.: The evolution of portal hypertension surgery: lessons from 1000 operations and 50 years’ experience. Arch. Surg. 2000; 135: 1389–1393

    Article  PubMed  CAS  Google Scholar 

  97. Pai, C.G., Thomas, V., Hariharan, M., Nair, K.V.: Rectal varices in extrahepatic portal hypertension. J. Gastroenterol. Hepatol. 1993; 8: 244–246.

    Article  PubMed  CAS  Google Scholar 

  98. Palazzo, L., Hochain, P., Helmer, C., Cuillerier, E., Landi, B., Roseau, G., Gugnenc, P.H., Barbier, J.-P., Cellier, C.: Biliary varices on endoscopic ultrasonography: clinical presentation, and outcome. Endoscopy 2000; 32: 520–524

    Article  PubMed  CAS  Google Scholar 

  99. Papadimitriou, J., Kannas, D., Papadimitriou, L.: Portal hypertension due to hydatid disease of the liver. J. Royal Soc. Med. 1990; 83: 120–121

    CAS  Google Scholar 

  100. Patch, D., Armonis, A., Sabin, C., Christopoulou, K., Greenslade, L., McCormick, A., Dick, R.: Single portal pressure measurement predicts survival in cirrhotic patients with recent bleeding. Gut 1999; 44: 264–269

    Article  PubMed  CAS  Google Scholar 

  101. Perez-Ayuso, R.M., Piqué, J.M.: Portal hypertension gastropathy. Dig. Dis. 1991; 9: 294–302

    Article  PubMed  CAS  Google Scholar 

  102. Piontek, M., Hengels, K.J., Borchard, F., Strohmeyer, G.: Nicht-zirrhotische Leberfibrose nach chronischer Arsen intoxikation. Dtsch. Med. Wschr. 1989; 114: 1653–1657

    PubMed  CAS  Google Scholar 

  103. Ponce Gonzales, J.F., Dominguez Adame Lanuza, E.D., Martin Zurita, I., Morales Mendez, S.: Portal hypertensive colopathy: histologic appearance of the colonic mucosa. Hepato-Gastroenterol. 1998; 45: 40–43

    Google Scholar 

  104. Portmann, B., Stewart, S., Higenbottam, T.W., Clayton, P.T., Lloyd, J.K., Williams, R.: Nodular transformation of the liver associated with portal and pulmonary arterial hypertension. Gastroenterology 1993; 104: 616–621

    PubMed  CAS  Google Scholar 

  105. Primentel, J., Menezes, A.: Liver disease in vineyard sprayers. Gastroenterology 1977; 72: 275–283

    Google Scholar 

  106. Primignani, M., Carpinelli, L., Preatoni, P., Battaglia, G., Carta, A., Prada, A., Cestari, R., Angeli, P., Gatta, A., Rossi, A., Spinzi, G., de Franchis, R.: Natural history of portal hypertensive gastropathy in patients with liver cirrhosis. Gastroenterology 2000; 119: 181–187

    Article  PubMed  CAS  Google Scholar 

  107. Quereshi, H., Zuberi, S.J., Maher, M., Ahmed, W., Alam, S.E., Jafarey, N.A.: Idiopathic portal hypertension: an overlooked entity. Hepatol. Res. 1998; 12: 169–176

    Article  Google Scholar 

  108. Raia, S., Caetano da Silva, L., Gayotto, L.C.C., Coutinho Forster, S., Fukushima, J., Strauss, E.: Portal hypertension in schistosomiasis: a long term follow-up of a randomized trial comparing three types of surgery. Hepatology 1994; 20: 398–403

    Article  PubMed  CAS  Google Scholar 

  109. Rigau, J., Bosch, J., Bordas, J.M., Navasa, M., Mastai, R., Kravetz, D., Bruix, J., Feu, F., Rodes, J.: Endoscopic measurement of variceal pressure in cirrhosis: correlation with portal pressure and variceal hemorrhage. Gastroenterology 1989; 96: 873–880

    PubMed  CAS  Google Scholar 

  110. Rockey, D.C.: The cellular pathogenesis of portal hypertension: stellate cell contractility, endothelin and nitric oxide. Hepatology, 1997; 25: 2–5

    Article  PubMed  CAS  Google Scholar 

  111. Rondonotti, E., Villa, F., Signorelli, C., de Franchis, R.: Portal hypertensive enteropathy. Gastrointest. Endosc. Clin. North Amer. 2006; 16: 277–286

    Article  Google Scholar 

  112. Russel, R.M., Boyer, J.L., Bagheri, S.A., Hruban, Z.: Hepatic injury from hypervitaminosis A resulting in portal hypertension and ascites. New Engl. J. Med. 1974; 291: 435–440

    Google Scholar 

  113. Ruttenberg, D., Graham, S., Burns, D., Solomon, D., Bornman, P.: Abdominal tuberculosis — a cause of portal vein thrombosis and portal hypertension. Dig. Dis. Sci. 1991; 36: 112–115

    Article  PubMed  CAS  Google Scholar 

  114. Sarin, S.K., Lahoti, D., Saxena, S.P., Murthy, N.S., Makwana, U.K.: Prevalence, classification and natural history of gastric varices: a longterm follow-up study in 568 portal hypertension patients Hepatology 1992; 16: 1343–1349

    Article  PubMed  CAS  Google Scholar 

  115. Shepherd, P., Harrison, D.J.: Idiopathic portal hyertension, associated with cytotoxic drugs. J. Clin. Pathol. 1990; 43: 206–210

    Article  PubMed  CAS  Google Scholar 

  116. Sherlock, S., Feldman, C.A., Moran, B., Scheuer, P.J.: Partial nodular transformation of the liver with portal hypertension. Amer. J. Med. 1966; 40: 195–203

    Article  PubMed  CAS  Google Scholar 

  117. Shi, B.M., Wang, X.Y., Zhang, L., Yang, Z., Xu, J., Mu, Q.L. Wu, T.H.: Regional portal hypertension diagnosed by ultrasonography: imaging findings and diagnostic value. Hepato-Gastroenterol. 2005; 52: 1062–1065

    Google Scholar 

  118. Shibayama, Y., Nakata, K.: The relation of periportal fibrosis to portal hypertension. J. Hepatol. 1990; 11: 313–317

    Article  PubMed  CAS  Google Scholar 

  119. Sieber, C.C., Stalder, G.A.: Pathophysiologische und pharmakotherapeutische Aspekte der portalen Hypertonie. Schweiz. Med. Wschr. 1993; 123: 3–13

    PubMed  CAS  Google Scholar 

  120. Smart, H.L., Triger, D.R.: Clinical features, pathophysiology and relevance of portal hypertensive gastropathy. Endoscopy 1991; 23: 224–228

    Article  PubMed  CAS  Google Scholar 

  121. Spech, H.J., Wördehoff, D.: Klassifizierung von Ösophagusvarizen — endoskopische und klinische Aspekte. Leber Magen Darm 1982; 12: 109–114

    PubMed  CAS  Google Scholar 

  122. Spech, H.J., Pape, W.: Kavernöse Pfortadertransformation. Dtsch. Med. Wschr. 1987; 112: 1137–1139

    PubMed  CAS  Google Scholar 

  123. Staritz, M., Rambow, A.: Messung des hydrostatischen Druckes in Ösphagusvarizen. Wissenschaftliche Befunde und klinsche Bedeutung. Dtsch. Med. Wschr. 1990; 115: 382–385

    PubMed  CAS  Google Scholar 

  124. Ströhmeyer, F.W., Ishak, K.G.: Nodular transformation (nodular “regenerative” hyperplasia) of the liver: A clinicopathologic study of 30 cases. Human Pathol 1981; 12: 60–71

    Article  Google Scholar 

  125. Sung, J.J.Y., Lee, Y.T., Leong, R.W.L.: EUS in portal hypertension. Gastrointest. Endosc. 2002; 56 (Suppl.): 35–43

    Article  Google Scholar 

  126. Tahri, N., Ben Amor, M.M., Njeh, M., Sallemi, A., Krichen, M.S.: Aspects colonoscopiques de ľhypertension portale. Etude prospective de 31 cas. Ann. Gastroenterol. Hépatol. 1997; 33: 205–211

    Google Scholar 

  127. Tassoni, J.P. jr., Fawaz, K.A., Johnston, D.E.: Cirrhosis and portal hypertension in a patient with adult Niemann-Pick disease. Gastroenterology 1991; 100: 567–569

    PubMed  Google Scholar 

  128. Taylor, C.R.: Computed tomography in the evaluation of the portal venous system. J. Clin. Gastroenterol. 1992; 14: 167–172

    Article  PubMed  CAS  Google Scholar 

  129. Tekeste, H., Latour, F., Levitt, R.E.: Portal hypertension complicating sarcoid liver disease: case report and review of the literature. Amer. J. Gastroenterol. 1984; 79: 389–396

    CAS  Google Scholar 

  130. Thuluvath, P.J., Yoo, H.Y.: Portal hypertensive gastropathy (review). Amer. J. Gastroenterol. 2002 97: 2973–2978

    Article  Google Scholar 

  131. Tsuneyama, K., Kouda, Nakanuma, Y.: Portal and parenchymal afterations of the liver in idiopathic portal hypertension: a histological and immunochemical study. Path. Res. Prac. 2002; 198: 579–603

    Google Scholar 

  132. Urata, J., Yamashita, Y., Tsuchigame, T., Hatanaka Y., Matsukawa, T., Sumi, S., Matsuno, Y., Takahashi, M.: The effects of transjugular intrahepatic portosystemic shunt on portal hypertensive gastropathy. J. Gastroenterol. Hepatol. 1998; 13: 1061–1067

    Article  PubMed  CAS  Google Scholar 

  133. Vakili, C., Farahvash, M.J., Bynum, T.E.: “Endemic” idiopathic portal hypertension: report on 32 patients with non-cirrhotic portal fibrosis. World J. Surg. 1992; 16 118–125

    Article  PubMed  CAS  Google Scholar 

  134. Valla, D., Pessegueiro-Miranda, H., Degott, C., Lebrec, D., Rueff, B., Benhamou, J.P.: Hepatic sarcoidosis with portal hypertension. A report of seven cases with a review of the literature. Quart. J. Med. 1987; 63: 531–544

    PubMed  CAS  Google Scholar 

  135. Valla, D., Casadevall, N., Huisse, M.G., Tulliez, M., Grange, J.D., Müller, O., Binda, T., Varet, B., Rueff, B., Benhamou J.P.: Etiology of portal vein thrombosis in adults A prospective evaluation of primary myeloproliferative disorders. Gastroenterology 1988; 94: 1063–1069

    PubMed  CAS  Google Scholar 

  136. Valla, D., Flejou, J.F., Lebrec, D., Bernuau, J., Rueff, B., Salzmann, J.L., Benhamou, J.P.: Portal hypertension and ascites in acute hepatitis: clinical, hemodynamic and histological correlations. Hepatology 1989; 10: 482–487

    Article  PubMed  CAS  Google Scholar 

  137. Vescia, F.G., Babb, R.R.: Colonic varices: a rare, but important cause of gastrointestinal hemorrhage. J. Clin. Gastroenterol. 1985; 7: 63–65

    Article  PubMed  CAS  Google Scholar 

  138. Viggiano, T.R., Gostout, C.J.: Portal hypertensive intestinal vasculopathy: a review of the clinical, endoscopic, and histopathologic features. Amer. J. Gastroenterol. 1992; 87: 944–954

    CAS  Google Scholar 

  139. Vignali, C., Bargellini, I., Grosso, M., Passalacqua, G., Maglione, F., Pedrazzini, F., Filauri, P., Niola, R., Cioni, R., Petruzzi, P.: TIPS with expanded polytetrafluoroethylene-covered stent: Resultats of an Italian multicenter study. Amer. J. Roentgenol. 2005; 185: 472–480

    Google Scholar 

  140. Vigneri, S., Termini, R., Piraino, A., Scialabba, A., Bovero, E., Pisciotta, G., Fontana, N.: The duodenum in liver cirrhosis: endoscopic, morphological and clinical findings. Endoscopy 1991; 23: 210–212

    Article  PubMed  CAS  Google Scholar 

  141. Vigneri, S., Termini, R., Piraino, A., Scialabba, A., Pisciotta, G., Fontana, N.: The stomach in liver cirrhosis. Endoscopic, morphological, and clinical correlations. Gastroenterology 1991; 101: 472–478

    PubMed  CAS  Google Scholar 

  142. Vilgrain, V., Lebrec, D., Menu, Y., Scherrer, A., Nahum, H.: Comparison between ultrasonographic signs and the degree of portal hypertension in patients with cirrhosis. Gastrointest, Radiol. 1990; 15: 218–222

    Article  CAS  Google Scholar 

  143. Vosshenrich, R., Fischer, U., Grabbe, E.: MR angiography in portal hypertension. State of the art. Radiologe, 2001; 41: 868–876

    Article  PubMed  CAS  Google Scholar 

  144. Wanless, I.R., Lentz, J.S., Roberts, E.A.: Partial nodular transformation of liver in an adult with persistent ductus venosus. Review with hypothesis on pathogenesis. Arch. Path. Lab. Med. 1985; 109: 429–432

    Google Scholar 

  145. Wanless, I.R.: Micronodular transformation (nodular regenerative hyperplasia) of the liver: a report of 64 cases among 2500 autopsies and a new classification of benign hepatocellular nodules. Hepatology 1990; 11: 787–797

    Article  PubMed  CAS  Google Scholar 

  146. Wanless, I.R.: Noncirrhotic portal hypertension: recent concepts. Progr. Liver Dis. 1997; 14: 265–278

    Google Scholar 

  147. Weiler, H., Weiler, Ch., Gerok, W.: Decreased prostaglandin E2 immunoactivity of gastric mucosa in portal hypertension. Netherl. J. Med. 1991; 38: 4–12

    CAS  Google Scholar 

  148. Weinshel, E., Chen, W., Falkenstein, D.B., Kessler, R., Raicht, R.F.: Hemorrhoids or rectal varices: defining the cause of massive rectal hemorrhage in patients with portal hypertension. Gastroenterology 1986; 90: 744–747

    PubMed  CAS  Google Scholar 

  149. West, M.S., Garra, B.S., Horti, S.C., Hayes, W.S., Cooper, C., Silverman, P.M., Zeman, R.K.: Gall bladder varices imaging findings in patients with portal hypertension. Radiology 1991; 179: 179–182

    PubMed  CAS  Google Scholar 

  150. Wilson, K.W., Robinson, D.C., Hacking, P.M.: Portal hypertension in childhood. Brit. J. Surg. 1969; 56: 13–22

    Article  PubMed  CAS  Google Scholar 

  151. Youssef, A.I., Escalante-Glorsky, S., Bonnet, R.B., Chen, Y.K.: Hemoptysis secondary to bronchial varices associated with alcoholic liver cirrhosis and portal hypertension. Amer. J. Gastroenterol. 1994; 89: 1562–1563

    CAS  Google Scholar 

  152. Ytting, H., Henriksen, J.H., Fugisang, S., Bendtsen, F., Moller, S.: Prolonged Q-T (c) interval in mild portal hypertensive cirrhosis. J. Hepatol. 2006; 43: 637–644

    Article  Google Scholar 

  153. Zeijen, R.N.M., Sels, J.P.J.E., Flendrig, J.A., Arends, J.W.: Portal hypertension and intrahepatic cholestasis in hepatic amyloidosis. Netherl. J. Med. 1991; 38: 257–261

    CAS  Google Scholar 

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(2008). Portal hypertension. In: Hepatology Textbook and Atlas. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76839-5_14

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