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Molecular Imaging in Cardiology

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Molecular Imaging

Abstract

In order to address the clinical issues associated with coronary artery disease and congestive heart failure, the current major diagnostic imaging procedures in nuclear cardiology are based on the assessment of myocardial blood flow and substrate metabolism using FDA approved SPECT and PET radiopharmaceuticals. Molecular imaging using biologically targeted radiopharmaceuticals will play a key role in an interdisciplinary approach to understanding the origins, pathogenesis, and the progress of cardiac diseases, and in the evaluation of therapeutic interventions. This chapter will provide a broad overview of the mechanisms involved in myocardial uptake and localization of current and the investigational radiopharmaceuticals in nuclear cardiology. Specifically, the design and development of molecular imaging radiotracers to image the myocardial fatty acid metabolism, adrenergic innervation, angiogenesis, and vulnerable plaque will be discussed. The potential clinical utility of these molecular imaging probes is also presented with specific examples.

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(2009). Molecular Imaging in Cardiology. In: Molecular Imaging. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76735-0_17

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