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Clinical Evaluation

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Abstract

Renal disease in children may present with overt abnormalities clearly associated with the urinary tract, such as the development of macroscopic haematuria or profound oliguria. However, in many instances symptoms may be very non specific or seemingly mild. Children with chronic renal failure present with a wide variety of symptoms including enuresis, failure to thrive, short stature, lethargy and pallor. The onset may be silent and the progress insidious, with symptoms only developing late in its course. Urinary tract infection in infants and small children may, in contrast to older children, present with non-specific manifestations including poor feeding, vomiting, irritability, abdominal pain, failure to thrive, lethargy and restlessness. The possibility of renal disease should therefore be considered in the differential diagnosis of any child presenting to hospital with acute or chronic symptoms.

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References

  1. Garrett WJ, Grunwald G, Robinson DE. Prenatal diagnosis of fetal polycystic kidney by ultrasound. Aust NZ J Obst Gynaecol 1970;10:7–9.

    Article  CAS  Google Scholar 

  2. De Bruyn R, Marks SD. Postnatal investigation of fetal renal disease. Semin Fetal Neonatal Med 2008;13:133–141.

    Article  PubMed  Google Scholar 

  3. Helin I, Persson PH. Prenatal diagnosis of urinary tract abnormalities by ultrasound. Pediatrics 1986;78(5):879–883.

    PubMed  CAS  Google Scholar 

  4. Livera LN, Brookfield DS, Egginton JA et al. Antenatal ultrasonography to detect fetal renal abnormalities: a prospective screening programme. BMJ 1989;298(6685):1421–1423.

    Article  PubMed  CAS  Google Scholar 

  5. Smith NC, Hau C. A six year study of the antenatal detection of fetal abnormaility in six Scottish health boards. Br J Obstet Gynaecol 1999;106:206–212.

    Article  PubMed  CAS  Google Scholar 

  6. DeCramer S, Parant O, Beaufils S et al. Anomalies of the TCF2 gene are the main cause of fetal bilateral hyperechogenic kidneys. J Am Soc Nephrol 2007;18(3):923–933.

    Article  PubMed  CAS  Google Scholar 

  7. Meadow R. Munchausen syndrome by proxy. Arch Dis Child 1982;57:92–98.

    Article  PubMed  CAS  Google Scholar 

  8. McGee H. On food and cooking: the science and lore of the kitchen. New York, Simon and Schuster, 1997, p. 194.

    Google Scholar 

  9. White RH. Occurrence of S-methyl thioesters in urine of humans after they have eaten asparagus. Science 1975;189:810–811.

    Article  PubMed  CAS  Google Scholar 

  10. Waring RH, Mitchell SC, Fenwick GR. The chemical nature of the urinary odour produced by man after asparagus ingestion. Xenobiotica 1987;17:1363–1371.

    Article  PubMed  CAS  Google Scholar 

  11. Sherry SN, Kramer I. The time of passage of the first urine by the newborn infant. J Pediatr 1955;46:158.

    Article  PubMed  CAS  Google Scholar 

  12. Muellner S. Development of urinary control in children. JAMA 1960:172:1256–1261.

    Article  CAS  Google Scholar 

  13. Forsythe WI, Redmond A. Enuresis and spontaneous cure rate. A study of 1129 enuretics. Arch Dis Child 1974;49(4):259–263.

    Article  PubMed  CAS  Google Scholar 

  14. Kitagawa T. Lessons learned from the Japanese nephritis screening study. Pediat Nephrol 1988;2:256–263.

    Article  PubMed  CAS  Google Scholar 

  15. Sinha MD, Reid CJ. Evaluation of blood pressure in children. Curr Opin Nephrol Hypertens 2007;16:577–584.

    Article  PubMed  Google Scholar 

  16. Jakobbson B, Esbjorner E, Hansson S. Minimum incidence and diagnostic rate of first urinary tract infection. Pediatrics 1999;104:222–226.

    Article  Google Scholar 

  17. Coulthard MG, Lambert H, Keir M. Occurrence of renal scars in children after their first referral for urinary tract infection. BMJ 1997;315:918–919.

    Article  PubMed  CAS  Google Scholar 

  18. Cooper WO, Hernandez-Diaz S, Arbogast PG et al. Major congenital malformations after first-trimester exposure to ACE inhibitors. N Engl J Med 2006;354(23):2443–2451.

    Article  PubMed  CAS  Google Scholar 

  19. Rasmussen SA, Chu SY, Kim SY et al. Maternal obesity and risk of neural tube defects: a metaanalysis. Am J Obstet Gynecol 2008;198(6):611–619.

    Article  PubMed  Google Scholar 

  20. Singh HP, Hurley RM, Myers TF. Neonatal hypertension: incidence and risk factors. Am J Hypertens 1992;5:51–55.

    PubMed  CAS  Google Scholar 

  21. Thummala MR, Raju TN, Langenberg P. Isolated single umbilical artery anomaly and the risk for congenital malformations: a meta-analysis. J Pediatr Surg 1998;33:580–585.

    Article  PubMed  CAS  Google Scholar 

  22. Darr A, Modell B. The frequency of consanguineous marriage among British Pakistanis. J Med Genet 1988;25:186–190.

    Article  PubMed  CAS  Google Scholar 

  23. Moghal NE, Milford DV, Hulton SA, Taylor CM. The prevalence and treatment of end stage renal disease in an Asian child population. Nephrol Dial Transpl 1997.

    Google Scholar 

  24. Connolly LP, Treves ST, Connolly SA et al. Vesicoureteric reflux in children: incidence and severity in siblings. J Urol 1997;157(6):2287–2290.

    Article  PubMed  CAS  Google Scholar 

  25. Nash D. The development of micturition control with special reference to enuresis. Ann R Coll Surg Eng 1949;5:318–344.

    CAS  Google Scholar 

  26. Flynn JT, Alderman MH. Characteristics of children with primary hypertension seen at a referral center. Pediatr Nephrol 2005;20(7):961–966.

    Article  PubMed  Google Scholar 

  27. Rianthovorn P, Ettenger RB. Medication non-adherence in the adolescent renal transplant recipient: a clinician’s viewpoint. Pediatr Transplant 2005;9(3):398–407.

    Article  Google Scholar 

  28. Foster BJ, Leonard MB. Nutrition in children with kidney disease: pitfalls of popular assessment methods. Perit Dial Int 2005;25(Suppl 3):S143–S146.

    PubMed  Google Scholar 

  29. Gavrilovici C, Goldsmith DJ, Reid C. What is the role of ambulatory BP monitoring in pediatric nephrology? J Nephrol 2004;17(5):642–652.

    PubMed  Google Scholar 

  30. Merten DF, Kirks DR. Diagnostic imaging of paediatric abdominal masses. Pediatr Clin North Am 1985;32:1397–1425.

    PubMed  CAS  Google Scholar 

  31. Ikeda M, Ito S, Hataya H et al. Reversible posterior leukoencephalopathy in a patient with minimal change nephrotic syndrome. Am J Kidney Dis 2001;37(4):E30.

    Article  PubMed  CAS  Google Scholar 

  32. Ishikura M, Ikeda M, Hamasaki Y et al. Posterior reversible leukoencephalopathy syndrome in children: its high prevalence and more extensive imaging findings. Am J Kidney Dis 2006;48(2):231–238.

    Article  PubMed  Google Scholar 

  33. Berlyne GM, Shaw AB. Red eyes in renal failure. Lancet 1967;i:4–7.

    Article  Google Scholar 

  34. Deshpande SA, Watson H. Renal ultrasonography not required in babies with isolated minor ear anomalies. Arch Dis Child Fetal Neonatal Ed 2006;91(1):F29–F30.

    Article  PubMed  CAS  Google Scholar 

  35. Currarino G, Coln D, Votteler G. Triad of anorectal, sacral and presacral anomalies. AJR Am J Roentgenol 1981;137(2):395–398.

    PubMed  CAS  Google Scholar 

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© 2009 Springer-Verlag Berlin Heidelberg

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Shenoy, M., Webb, N.J.A. (2009). Clinical Evaluation. In: Avner, E., Harmon, W., Niaudet, P., Yoshikawa, N. (eds) Pediatric Nephrology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-76341-3_20

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  • DOI: https://doi.org/10.1007/978-3-540-76341-3_20

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-76327-7

  • Online ISBN: 978-3-540-76341-3

  • eBook Packages: MedicineReference Module Medicine

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