Abstract
Most of the biomaterials used nowadays for the reconstruction of the spinal cord tissue after an injury, tested in animals, have obtained modest results. This work presents a study about the effect of three novels, biocompatible and semi-conductive materials, obtained by plasma polymerization: poly-pyrrole (PPy), iodine-doped pyrrole (PPy/I) and pyrrole-polyethylene glycol (PPy/PEG). These polymers, separately, were implanted in the spinal cord tissue of rats after a trans-section. We used adult female Long Evans rats, submitted at electrodes implantation into sensory cortex, one week after all animals were subjected to complete spinal cord transection and neurophysiology recovery was evaluated with open field-BBB scale and somatosensory evoked potentials. The results showed motor recovery only in animals with PPy implant vs control group (without implant). In conclusion, implant of PPy is fine tolerated from spinal cord tissue and improvement conduction and function after spinal cord transaction.
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Mondragón Lozano, R. et al. (2007). Evaluación electrofisiológica del efecto de tres implantes poliméricos en la función nerviosa en un modelo de lesión por sección completa de la médula espinal en ratas. In: Müller-Karger, C., Wong, S., La Cruz, A. (eds) IV Latin American Congress on Biomedical Engineering 2007, Bioengineering Solutions for Latin America Health. IFMBE Proceedings, vol 18. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-74471-9_152
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DOI: https://doi.org/10.1007/978-3-540-74471-9_152
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