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Diagnosis of Acute Lymphoblastic Leukemia

  • Chapter
Acute Leukemias

Part of the book series: Hematologic Malignancies ((HEMATOLOGIC))

Abstract

The diagnosis of acute lymphoblastic leukemia (ALL) is dependent on the identification and characterization of blast cells in peripheral blood or bone marrow. Although it is not clear why blasts have a tendency to circulate in some patients and not in others, ALL can be reliably diagnosed using peripheral blood or bone marrow blasts when blasts are in circulation [79]. However, distinguishing blasts from activated lymphocytes is difficult in some patients, particularly children. Standard care and thorough evaluation of patients with ALL thus require good bone marrow aspiration, with high-quality smears and bone marrow biopsy specimens. When bone marrow biopsy specimens are available, touch imprints should be made [1].

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  1. Quest Diagnostics Nichols Institute, San Juan Capistrano, CA, USA

    Maher Albitar

  2. Department of Leukemia, The University of Texas M.D. Anderson Cancer Center, Houston, TX, USA

    Hagop Kantarjian

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Albitar, M., Giles, F.J., Kantarjian, H. (2008). Diagnosis of Acute Lymphoblastic Leukemia. In: Acute Leukemias. Hematologic Malignancies. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-72304-2_8

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