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Pharmacological Assays in Thrombosis and Haemostasis

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Drug Discovery and Evaluation

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General Introduction

Cardiovascular, cerebrovascular, and venous thromboembolic disorders continue to be the leading causes of death throughout the world. Over the past two decades, great advances have been made in the pharmacological treatment and prevention of arterial and venous thrombotic disorders (e. g., tissue plasminogen activators, platelet GPIIb/IIIa antagonists, and ADP receptor antagonists such as clopidogrel, low-molecular weight heparins, and direct thrombin inhibitors). New research is leading to the next generation of antithrombotic compounds such as direct coagulation FVIIa inhibitors, tissue factor pathway inhibitors, gene therapy, and orally active direct thrombin inhibitors and coagulation factor Xa (FXa) inhibitors. In vitro assays as well as animal models of thrombosis have played and will continue to play crucial roles in the discovery and validation of novel drug targets, the selection of new agents for clinical evaluation, and the provision of dosing and safety...

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Vogel, H. (2007). Pharmacological Assays in Thrombosis and Haemostasis. In: Vogel, H.G. (eds) Drug Discovery and Evaluation. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70995-4_3

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