Abstract
This study aims at characterizing and modelling the effect of mechanical factors on endothelial denudation during angioplasty, such as normal force between balloon and artery, stretching of arterial walls, and relative displacement between contacting surfaces. Friction damage was applied to porcine aorta samples with different contact forces, relative displacements, and biplanar stretching conditions. After the tests, endothelium denudation was quantified by isolating and counting the remaining endothelial cells. Using multiple-regression analysis, a constitutive model is proposed for integration in finite element software. This model will help optimize balloon and stent deployment conditions to minimize the amount of damage to the endothelium, and eventually to reduce the occurrence of restenosis.
This is a preview of subscription content, log in via an institution.
Buying options
Tax calculation will be finalised at checkout
Purchases are for personal use only
Learn about institutional subscriptionsPreview
Unable to display preview. Download preview PDF.
References
Kiemeneij, F., Serruys, P.W., Macaya, C., et al.: Continued benefit of coronary stenting versus balloon angioplasty: five-year clinical follow-up of Benestent-I trial. J. Am. Coll. Cardiol. 37, 1598–1603 (2001)
Serruys, P.W., Luijten, H.E., Beatt, K.J., et al.: Incidence of restenosis after successful coronary angioplasty: a time-related phenomenon. A quantitative angiographic study in 342 consecutive patients at 1, 2, 3, and 4 months. Circulation 77, 361–371 (1988)
Hoffmann, R., Mintz, G.S., Mehran, R., et al.: Tissue proliferation within and surrounding Palmaz-Schatz stents is dependent on the aggressiveness of stent implantation technique. Am. J. Cardiol. 83, 1170–1174 (1999)
Koyama, J., Owa, M., Sakurai, S., et al.: Relation between vascular morphologic changes during stent implantation and the magnitude of in-stent neointimal hyperplasia. Am. J. Cardiol. 86, 753–758 (2000)
Schwartz, R.S., Huber, K.C., Murphy, J.G., et al.: Restenosis and the proportional neointimal response to coronary artery injury: results in a porcine model. J. Am. Coll. Cardiol. 19, 267–274 (1992)
Kuntz, R.E., Safian, R.D., Carrozza, J.P., et al.: The importance of acute luminal diameter in determining restenosis after coronary atherectomy or stenting. Circ. 86, 1827–1835 (1992)
Capron, L., Bruneval, P.: Influence of applied stress on mitotic response of arteries to injury with a balloon catheter: quantitative study in rat thoracic aorta. Cardiovasc. Res. 23, 941–948 (1989)
Olson, N.E., Chao, S., Lindner, V., Reidy, M.A.: Intimal smooth muscle cell proliferation after balloon catheter injury. The role of basic fibroblast growth factor. Am. J. Pathol. 140, 1017–1023 (1992)
Jamal, A., Bendeck, M., Langille, B.L.: Structural changes and recovery of function after arterial injury. Arterioscler. Thromb. Vasc. Biol. 12, 307–317 (1992)
Rogers, C., Tseng, D.Y., Squire, J.C., Edelman, E.R.: Balloon-artery interactions during stent placement: a finite element analysis approach to pressure, compliance, and stent design as contributors to vascular injury. Circ. Res. 84, 378–383 (1999)
Caldwell, R.A., Woodell, J.E., Ho, S.P., et al.: In vitro evaluation of phosphonylated low-density polyethylene for vascular applications. J. Biomed. Mater. Res. 62, 514–524 (2002)
Multiple Regression. In: NCSS User’s Guide, pp. 305-1–305-98 (2007)
Umeda, H., Iwase, M., Kanda, H.: Promising efficacy of primary gradual and prolonged balloon angioplasty in small coronary arteries: A randomized comparison with cutting balloon angioplasty and conventional balloon bngioplasty. Am. Heart J. 147, 1–8 (2004)
Weiss, T., Leibovitz, D., Katz, I., Danenberg, C., Varshitsky, B., Lotan, C.: The value of computerized angioplasty in patients undergoing coronary stenting: a prospective, randomized trial. Am. J. Cardiol. 100, 118 (2007)
Virues Delgadillo, J.O., Delorme, S., DiRaddo, R., Hatzikiriakos, S.: Stiffness of porcine aortas decreases with strain-rate. Simulation in Healthcare 2, 156 (2007)
Laroche, D., Delorme, S., Anderson, T., DiRaddo, R.: Computer prediction of friction in balloon angioplasty and stent implantation. In: Harders, M., Székely, G. (eds.) ISBMS 2006. LNCS, vol. 4072, pp. 1–8. Springer, Heidelberg (2006)
Author information
Authors and Affiliations
Editor information
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg
About this paper
Cite this paper
Delorme, S., El-Ayoubi, R., Debergue, P. (2008). Constitutive Modelling of Endothelium Denudation for Finite Element Simulation of Angioplasty. In: Bello, F., Edwards, P.J.E. (eds) Biomedical Simulation. ISBMS 2008. Lecture Notes in Computer Science, vol 5104. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-70521-5_3
Download citation
DOI: https://doi.org/10.1007/978-3-540-70521-5_3
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-70520-8
Online ISBN: 978-3-540-70521-5
eBook Packages: Computer ScienceComputer Science (R0)