Diabetic macular edema is the most common cause of visual impairment in patients with diabetes mellitus, and it affects approximately 75,000 new patients in the United States every year [14, 65, 66]. The incidence of macular edema significantly increases with increasing severity of diabetes in both early-onset and late-onset diabetic patients [65, 66].
Diabetic macular edema tends to be a chronic disease. Although spontaneous recovery is not uncommon, 24% of eyes with clinically significant macular edema (CSME) and 33% of eyes with center-involving CSME will have a moderate visual loss (15 or more letters on the ETDRS chart) within three years if untreated [27, 31].
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Joussen, A. (2009). Is Diabetic Retinopathy an Inflammatory Disease? Inflammation as a Stimulus for Vascular Leakage and Proliferati on. In: Uveitis and Immunological Disorders. Essentials in Ophthalmology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69459-5_4
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