Abstract
The glomerular filtration rate (GFR) of the renal transplant usually averages around 40–50 ml/min. Thus, even slight decreases in GFR that may remain undetected in a healthy patient will cause a rapid increase in serum creatinine in the transplanted patient. Calcineurin inhibitors as part of immunosuppressive protocols may cause renal vasoconstriction and also interact with a variety of other drugs, thus potentially increasing their nephrotoxic potential. Acute allograft failure may occur in the context of severe infections, secondary to diarrhea and fluid loss, or as a consequence of disturbed (arterial of venous) graft perfusion. If these potential reasons have been investigated and excluded, a renal biopsy must be performed to establish the diagnosis of rejection.
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Schindler, R. (2010). Acute Kidney Transplant Failure. In: Jörres, A., Ronco, C., Kellum, J. (eds) Management of Acute Kidney Problems. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69441-0_44
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DOI: https://doi.org/10.1007/978-3-540-69441-0_44
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