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Polyposis Syndromes and Colorectal Cancer Predisposition

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Anorectal and Colonic Diseases

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Abstract

Colorectal polyps are common, affecting 25% of the population by age 75 years. However, the presence of multiple polyps, particularly in association with a personal or family history of colorectal cancer, should raise suspicion of a polyposis syndrome. The last decade has witnessed a dramatic increase in our understanding of polyposis syndromes and colorectal cancer predisposition. Here we discuss the polyposis syndromes that have been characterised to date and the implications for clinical practice (Table 33.1). Familial adenomatous polyposis provided the first example where the genetic lesion responsible for a dominantly inherited predisposition to cancer was elucidated, and it provided a window into the adenoma carcinoma sequence of sporadic cancer.

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Authors and Affiliations

  1. Department of Colorectal Surgery, The John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK

    Christopher Cunningham

  2. Colon Cancer Genetics Group, School of Molecular and Clinical Medicine and MRC, Human Genetics Unit, Western General Hospital, University of Edinburgh, EH4 2XU, Edinburgh, UK

    Rebecca A. Barnetson & Malcolm G. Dunlop

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  1. Christopher Cunningham
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  2. Rebecca A. Barnetson
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  3. Malcolm G. Dunlop
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Editors and Affiliations

  1. Service de Chirurgie Viscérale, Centre Hospitalier Universitaire Vaudois, 1011, Lausanne, Switzerland

    Jean-Claude R. Givel

  2. Department of Colorectal Surgery, The John Radcliffe Hospital, OX3 9DU, Headington, Oxford, UK

    Neil Mortensen

  3. Responsable de l’Unité de Proctologie, Hôpital Cantonal Universitaire de Genève, Rue Gabrielle Perret-Gentil 4, 1211, Genève 14, Switzerland

    Bruno Roche

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Cunningham, C., Barnetson, R., Dunlop, M. (2010). Polyposis Syndromes and Colorectal Cancer Predisposition. In: Givel, JC., Mortensen, N., Roche, B. (eds) Anorectal and Colonic Diseases. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-69419-9_33

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  • DOI: https://doi.org/10.1007/978-3-540-69419-9_33

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