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Medikamente zur Behandlung bipolarer affektiver Störungen

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Handbuch der Psychopharmakotherapie

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Die medikamentöse Behandlung bipolarer Störungen basiert, grob unterschieden, auf zwei Säulen: Stimmungsstabilisierern (die etwas holprige Übersetzung des englischen mood stabilizer) sowie Interventionsmedikamenten. In der älteren deutschen Literatur wird für Stimmungsstabilisierer auch oft der Begriff Phasenprophylaktika gebraucht. Dies spiegelt jedoch nur einen Aspekt dessen wider, was von den Medikamenten erwartet wird: Sie sollen nämlich nicht nur einen Rückfall verhüten, sondern auch eine akute Episode behandeln können. Als Interventionsmedikamente stehen verschiedenste Substanzen zur Verfügung, je nachdem, welches Symptom oder Syndrom durch den Stimmungsstabilisierer nicht hinreichend in den Griff zu bekommen ist. In der manischen Episode sind dies in der Regel konventionelle und atypische Antipsychotika, in der depressiven Episode die verschiedensten Antidepressiva. Sowohl in Manie als auch in Depression wird zusätzlich häufig Gebrauch von Benzodiazepinen gemacht, entweder zur Sedierung in manischen Episoden oder zur Anxiolyse und Schlafinduktion in beiden Affektauslenkungen.

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Authors
  1. Heinz Grunze
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  2. Anna Forsthoff
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Editors and Affiliations

  1. Max-Planck-Institut für Psychiatrie, Kraepelinstraße 2-10, 80804, München

    Florian Holsboer

  2. Klinik für Psychiatrie und Psychotherapie, Universitätsklinikum der Rheinisch-Westfälischen Technischen Hochschule Aachen, Pauwelsstraße 30, 52074, Aachen

    Gerhard Gründer

  3. Ehemals: Psychiatrische Klinik und Poliklinik der Johannes-Gutenberg-Universität Mainz, Untere Zahlbacher Straße 8, 55131, Mainz

    Otto Benkert

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Grunze, H., Forsthoff, A. (2008). Medikamente zur Behandlung bipolarer affektiver Störungen. In: Holsboer, F., Gründer, G., Benkert, O. (eds) Handbuch der Psychopharmakotherapie. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68748-1_29

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