Definition
Can refer to a reduction of total cellular protein of a receptor or, alternatively, a loss of receptor expression on the cell surface. The latter can arise from redistribution of receptor from surface to intracellular pools.
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Morgan, M.M., Christie, M.J. (2010). Downregulation. In: Stolerman, I.P. (eds) Encyclopedia of Psychopharmacology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-68706-1_1476
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DOI: https://doi.org/10.1007/978-3-540-68706-1_1476
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-68698-9
Online ISBN: 978-3-540-68706-1
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