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Potential Mechanisms by which Statins Modulate the Development of Acute Lung Injury

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Intensive Care Medicine

Part of the book series: Yearbook of Intensive Care and Emergency Medicine ((YEARBOOK,volume 2007))

Abstract

Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are characterized by acute hypoxemic respiratory failure and bilateral pulmonary infiltrates that are not attributable to left atrial hypertension [1]. ALI/ARDS is a heterogeneous disease with a complex pathophysiology that may occur in response to a direct pulmonary or indirect systemic injury [1]. ALI and ARDS are different spectrums of the same condition. ALI is characterized by a PaO2/FiO2 ratio of less than 300 mmHg (40 kPa). ARDS, the more severe end of the spectrum on the basis of oxygenation criteria, is defined by a PaO2/FiO2 ratio of less than 200 mmHg (26 kPa). A recent prospective cohort study estimated the incidence of ALI to be 79/100,000 person years [2]. Mortality remains high although more recent trials have reported a lower mortality [3, 4].

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Authors and Affiliations

  1. Department of Clinical Biochemistry Institute of Clinical Science, Queen’s University, Grosvenor Road, Belfast, BT12 6BJ, UK

    T. Craig & C. O’Kane

  2. Regional Intensive Care Unit, Royal Group of Hospitals, Grosvenor Road, Belfast, BT12 6BA, UK

    D. McAuley

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  2. C. O’Kane
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  3. D. McAuley
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Craig, T., O’Kane, C., McAuley, D. (2007). Potential Mechanisms by which Statins Modulate the Development of Acute Lung Injury. In: Intensive Care Medicine. Yearbook of Intensive Care and Emergency Medicine, vol 2007. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49433-1_25

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  • DOI: https://doi.org/10.1007/978-3-540-49433-1_25

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-49432-4

  • Online ISBN: 978-3-540-49433-1

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