Skip to main content
SpringerLink
Log in

Genetic Engineering of Plants and Microbial Cells for Flavour Production

  • Chapter
Flavours and Fragrances

26.7 Conclusion

The introduction of new genes into microorganisms and plants has become more or less a routine. But as long as the regulation mechanisms of biosynthetic pathways are not thoroughly understood, increased levels of desired metabolites will only be achieved randomly by metabolic engineering. Although genome sequencing projects constantly provide a huge number of new genes, their primary functions remain unknown, even when they show high similarity with already characterised structural genes. Detailed biochemical analyses of the recombinant proteins and studies with transgenic lines, where the gene has been downregulated and/or upregulated, are essential. Nevertheless, the few examples presented here already demonstrate that genetic and metabolic engineering has been quite successful for the production of flavours and has great potential.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 149.00
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 199.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 279.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  1. Watts KT, Mijts BN, Schmidt-Dannert C (2005) Advanced Synthesis and Catalysis 347:927–940

    Article  CAS  Google Scholar 

  2. Verpoorte R, van der Heijden R, Memelink J (2000) Transgenic Research 9:323–343

    Article  CAS  Google Scholar 

  3. Klaus SMJ, Huang F-C, Golds TJ, Koop H-U (2004) Nature Biotechnology 22:225–229

    Article  CAS  Google Scholar 

  4. Marillonnet S, Giritch A, Gils M, Kandzia R, Klimyuk V, Gleba Y (2004) Proceedings of the National Academy of Sciences of the United States of America 101:6852–6857

    Article  CAS  Google Scholar 

  5. Broun P, Somerville C (2001) Proceedings of the National Academy of Sciences of the United States of America 98:8925–8927

    Article  CAS  Google Scholar 

  6. Trapp S, Croteau RB (2001) Genetics 158:811–832

    CAS  Google Scholar 

  7. Martin VJJ, Pitera DJ, Withers ST, Newman JD, Keasling JD (2003) Nature Biotechnology 21:796–802

    Article  CAS  Google Scholar 

  8. Estévez JM, Cantero A, Reindl A, Reichler S, León P (2001) Journal of Biological Chemistry 276:22901–22909

    Article  Google Scholar 

  9. McCaskill D, Croteau R (1995) Planta 197:49–56

    Article  CAS  Google Scholar 

  10. Mahmound SS, Croteau R (2001) Proceedings of the National Academy of Sciences of the United States of America 98:8915–8920

    Article  Google Scholar 

  11. Lücker J, Bouwmeester HJ, Schwab W, Blaas J, van der Plas LH, Verhoeven HA (2001) Plant Journal 27:315–324

    Article  Google Scholar 

  12. Lavy M, Zuker A, Lewinsohn E, Larkov O, Ravid U, Vainstein A, Weiss D (2002) Molecular Breeding 9:103–111

    Article  CAS  Google Scholar 

  13. Lewinsohn E, Schalechet F, Wilkinson J, Matsui K, Tadmor Y, Nam KH, Amar O, Lastochkin E, Larkov O, Ravid U, Hiatt W, Gepstein S, Pichersky E (2001) Plant Physiology 127:1256–1265

    Article  CAS  Google Scholar 

  14. Aharoni A, Giri AP, Deuerlein S, Griepink F, de Kogel W-J, Verstappen FWA, Verhoeven HA, Jongsma MA, Schwab W, Bouwmeester HJ (2003) Plant Cell 15:2866–2884

    Article  CAS  Google Scholar 

  15. Lücker J, Schwab W, van Hautum B, Blass J, van der Plas LHW, Bouwmeester HJ, Verhoeven HA (2004) Plant Physiology 134:510–519

    Article  Google Scholar 

  16. Lücker J, Schwab W, Franssen MCR, van der Plas LHW, Bouwmeester HJ, Verhoeven HA (2004) Plant Journal 39:135–145

    Article  Google Scholar 

  17. Casey R, West SI, Hardy D, Robinson DS, Wu Z, Hughes RK (1999) Trends in Food Science and Technology 10:297–302

    Article  CAS  Google Scholar 

  18. Noordermeer MA, Veldink GA, Vliegenthart JFG (2001) Chembiochem 2:494–504

    Article  CAS  Google Scholar 

  19. Noordermeer MA, van Dijken AJH, Smeekens SCM, Veldink GA, Vliegenthart FG (2000) European Journal of Biochemistry 267:2473–2482

    Article  CAS  Google Scholar 

  20. Noordermeer MA, van der Goot W, van Kooij AJ, Veldsink JW, Veldink GA, Vliegenthart JFG (2002) Journal of Agricultural and Food Chemistry 50:4270–4274

    Article  CAS  Google Scholar 

  21. Fukushige H, Hildebrand DF (2005) Journal of Agricultural and Food Chemistry 53:2046–2051

    Article  CAS  Google Scholar 

  22. Bourel G, Nicaud J-M, Nthangeni B, Santiago-Gomez P, Belin J-M, Husson F (2004) Enzyme and Microbial Technology 35:293–299

    Article  CAS  Google Scholar 

  23. Fukushige H, Hildebrand DF (2005) Journal of Agricultural and Food Chemistry 53:6877–6882

    Article  CAS  Google Scholar 

  24. Matsui K, Fukutomi S, Wilkinson J, Hiatt B, Knauf V, Kajwara T (2001) Journal of Agricultural and Food Chemistry 49:5418–5424

    Article  CAS  Google Scholar 

  25. Griffiths A, Prestage S, Linforth R, Zhang J, Taylor A, Grierson D (1999) Postharvest Biology and Technology 17:163–173

    Article  CAS  Google Scholar 

  26. Chen G, Hackett R, Walker D, Taylor A, Lin Z, Grierson D (2004) Plant Physiology 136:2641–2651

    Article  CAS  Google Scholar 

  27. Salas JJ, Sanchez C, Garcia-Gonzalez DL, Aparicio R (2005) Journal of Agricultural and Food Chemistry 53:1648–1655

    Article  CAS  Google Scholar 

  28. Aharoni A Keizer LC Bouwmeester HJ Sun Z Alvarez-Huerta M Verhoeven HA Blass J van Houwelingen AM De Vos RC van der Voet Jansen H Guis M Mol J Davis RW Schena M van Tunen AJ O’Connell AP 2000 Plant Cell 12647–662

    Article  CAS  Google Scholar 

  29. Beekwilder J, Alvarez-Huerta M, Neef E, Verstappen FWA, Bouwmeester HJ, Aharoni A (2004) Plant Physiology 135:1865–1878

    Article  CAS  Google Scholar 

  30. Zuker A, Tzfira T, Ben-Meir H, Ovadis M, Shklarman E, Itzhaki H, Forkmann G, Martens S, Neta-Sharir I, Weiss D, Vainstein A (2002) Molecular Breeding 9:33–41

    Article  CAS  Google Scholar 

  31. Verstrepen KJ, Van Laere SDM, Vanderhaegen BMP, Derdelinckx G, Dufour J-P, Pretorius IS, Winderickx J, Thevelein JM, Delvaux FR (2003) Applied and Environmental Microbiology 69:5228–5237

    Article  CAS  Google Scholar 

  32. Vadali RV, Bennett GN, San K-Y (2004) Applied Microbiology and Biotechnology 63:698–704

    Article  CAS  Google Scholar 

  33. Vadali RV, Bennett GN, San K-Y (2004) Metabolic Engineering 6:294–299

    Article  CAS  Google Scholar 

  34. Ramachandra Rao S, Ravishankar GA (2002) Biotechnology Advances 20:1001–153

    Article  Google Scholar 

  35. Walton NJ, Narbad A, Faulds CB, Williamson G (2000) Current Opinion in Biotechnology 11:490–496

    Article  CAS  Google Scholar 

  36. Gasson MJ, Kitamura Y, McLauchlan WR, Narbad A, Parr AJ, Parsons ELH, Payne J, Rhodes MJC, Walton NJ (1998) Journal of Biological Chemistry 273:4163–4170

    Article  CAS  Google Scholar 

  37. Mitra A, Kitamura Y, Gasson MJ, Narbad A, Parr AJ, Payne J, Rhodes MJC, Seweter C, Walton NJ (1999) Archives of Biochemistry Biophysics 365:10–1

    Article  CAS  Google Scholar 

  38. Okeke BC, Venturi V (1999) Journal of Bioscience and Bioengineering 88:103–106

    Article  CAS  Google Scholar 

  39. Overhage J, Priefert H, Rabenhorst J, Steinbüchel A (1999) Applied Microbiology and Biotechnology 52:820–828

    Article  CAS  Google Scholar 

  40. Overhage J, Priefert H, Steinbüchel A (1999) Applied and Environmental Microbiology 65:4837–4847

    CAS  Google Scholar 

  41. Overhage J, Steinbüchel A, Priefert H (2003) Applied and Environmental Microbiology 69:6569–6576

    Article  CAS  Google Scholar 

  42. Li K, Frost JW (1998) Journal of the American Chemical Society 120:10545–10546

    Article  CAS  Google Scholar 

  43. Wang C, Chin C-K, Ho C-T, Hwang C-F, Polashock JJ, Martin CE (1996) Journal of Agricultural and Food Chemistry 44:3399–3402

    Article  CAS  Google Scholar 

  44. Speirs J, Lee E, Holt K, Yong-Duk K, Scott NS, Loveys B, Schuch W (1998) Plant Physiology 117:1047–1058

    Article  CAS  Google Scholar 

  45. Di R, Kim J, Martin MN, Leustek T, Jhoo J, Ho C-T, Tumer NE (2003) Journal of Agricultural and Food Chemistry 51:5695–5702

    Article  CAS  Google Scholar 

  46. Rijnen L, Courtin P, Gripon J-C, Yvon M (2000) Applied and Environmental Microbiology 66:1354–1359

    Article  CAS  Google Scholar 

  47. Hugenholtz J, Kleerebezem M, Starrenburg M, Delcour J, De Vos W, Hols P (2000) Applied and Environmental Microbiology 66:4112–4114

    Article  CAS  Google Scholar 

  48. Nevoigt E, Pilger R, Mast-Gerlach E, Schmidt U, Freihammer S, Eschenbrenner M, Garbe L, Stahl U (2002) FEMS Yeast Research 2:225–232

    CAS  Google Scholar 

  49. Waché Y, Laroche C, Bergmark K, Møller-Andersen C, Aguedo M, Le Dall M-T, Wang H, Nicaud J-M, Belin J-M (2000) Applied and Environmental Microbiology 66:1233–1236

    Article  Google Scholar 

  50. Groguenin A, Waché Y, Garcia EE, Aguedo M, Husson F, LeDall M-T, Nicaud J-M, Belin J-M (2004) Journal of Molecular Catalysis B: Enzymatic 28:75–79

    Article  CAS  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Biomolecular Food Technology, Technical University Munich, Lise-Meitner-Str. 34, 85354, Freising, Germany

    Wilfried Schwab

Authors
  1. Wilfried Schwab
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. FB Chemie, Institut für Lebensmittelchemie, Universität Hannover, Wunstorferstraße 14, 30453, Hannover, Germany

    Ralf Günter Berger

Rights and permissions

Reprints and permissions

Copyright information

© 2007 Springer-Verlag Berlin Heidelberg

About this chapter

Cite this chapter

Schwab, W. (2007). Genetic Engineering of Plants and Microbial Cells for Flavour Production. In: Berger, R.G. (eds) Flavours and Fragrances. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-49339-6_26

Download citation

Publish with us

Policies and ethics

Search

Navigation