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Neuroendokrine Tumoren des Pankreas und des Gastrointestinaltrakts

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Medizinische Therapie 2007 | 2008

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Gemeinsames Merkmal der neuroendokrinen Tumoren (NET) des gastroenteropankreatischen Systems (GEP-Systems) ist die Ausstattung mit einem Apparat zu Synthese und Sekretion von gastrointestinalen Hormonen, Neurotransmittern und Neuropeptiden. Er besteht aus »kleinen synaptischen Vesikelanaloga« und »sekretorischen Granula« und ist die Basis der immunhistologischen Charakterisierung (Chromogranin A, Synaptophysin). Nur bei etwa der Hälfte der Tumoren werden jedoch hormonaktive Substanzen in den Blutstrom sezerniert und führen so zum spezifischen Hypersekretionssyndrom (⊡ Tabelle 86.1). Die Einteilung in »funktionelle« und »nonfunktionelle« neuroendokrine Tumoren erfolgt ausschließlich nach klinischen Kriterien.

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Authors and Affiliations

  1. Campus Virchow-Klinikum Medizinische Klinik m. S. Hepatologie und Gastroenterologie, Charité — Universitätsmedizin Berlin, Augustenburger Platz 1, 13353, Berlin

    Dr. Michael Böhmig & Prof. Dr. Bertram Wiedenmann

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  1. Dr. Michael Böhmig
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  2. Prof. Dr. Bertram Wiedenmann
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Editors and Affiliations

  1. Klinik und Poliklinik für Innere Medizin I, Klinikum der Universität Regensburg, 93042, Regensburg

    Jürgen Schölmerich

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Böhmig, M., Wiedenmann, B. (2007). Neuroendokrine Tumoren des Pankreas und des Gastrointestinaltrakts. In: Schölmerich, J. (eds) Medizinische Therapie 2007 | 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48554-4_86

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  • DOI: https://doi.org/10.1007/978-3-540-48554-4_86

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-540-48553-7

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