Auszug
Sowohl primäre, d. h. vom Organ selbst ausgehende, als auch sekundäre Lebertumoren stellen differentialdiagnostisch und therapeutisch ein häufiges internistisches Problem dar. Sie werden im Rahmen der körperlichen Untersuchung (Hepatomegalie), Labordiagnostik (Erhöhung der Cholestaseparameter und Transaminasen) oder zufällig mittels bildgebender Verfahren wie z. B. Sonographie, Computertomographie und Magnetresonanztomographie entdeckt. Gerade die Differenzierung benigner von malignen Lebertumoren (⊡ Tabelle 77.1) erfordert auf Grund der daraus resultierenden therapeutischen Konsequenzen die Sicherung der Diagnose. Hierzu ist — bis auf wenige Ausnahmen — auch eine Biopsiegewinnung mittels Punktion, Laparoskopie oder sogar offener Gewebeentnahme im Rahmen einer Laparotomie notwendig.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
Preview
Unable to display preview. Download preview PDF.
Similar content being viewed by others
Literatur
Allen J, Venook A (2004) Hepatocellular carcinoma: epidemic and treatment. Curr Oncol Rep 6:177–183
Avila MA, Berasain C, Sangro B et al. (2006) New therapies for hepatocellular carcinoma. Oncogene 25:3866–3884
Bruix J, Hessheimer AJ, Forner A et al. (2006). New aspects of diagnosis and therapy of hepatocellular carcinoma. Oncogene 25:3848–3856
Bennett WF, Bova JG (1990) Review of hepatic imaging and a problem oriented approach to liver masses. Hepatology 12: 761–775
Bruix J, Sherman M, Llovet JM et al. (2001) Clinical management of hepatocellular carcinoma. Conclusions of the Barcelona-2000 EASL conference. J Hepatol 35:421–430
Camma C, Schepis F, Albanese M et al. (2002) Transarterial chemoembolization for unresectable hepatocellular carcinoma: metaanalysis of randomized controlled trials. Radiology 224: 47–54
Caselmann WH, Blum HE, Fleig WE et al. (1999) Leitlinien der Deutschen Gesellschaft für Verdauungs-und Stoffwechselkrankheiten zur Diagnostik und Therapie des hepatozel-lulären Karzinoms. Z Gastroenterol 37:353–365
Craig JR, Peters RL, Edmondson HA (1989) Tumors of the liver and intrahepativ bile ducts. In: Armed Forces Institute of Pathology (ed) Atlas of tumor pathology, 2nd series. Washington DC, 26, 1
Daliva JA, Morgan RO, Shaib Y et al. (2005) Diabetes increases the risk of hepatocellular carcinoma in the United States: A population-based case-control study. Gut 54:533–539
Dietrich CF (2004) Characterisation of focal liver lesions with contrast enhanced ultrasonography. Eur J Radiol 51S: S9–S17
Dietrich CF Schuessler G, Trojan M et al. (2005) Differentiation of focal nodular hyperplasia and hepatocellular adenoma by contrast-enhanced ultrasound. Br J Radiol 78:704–707
Groupe d’Etude et de Traitement du Carcinome Hepatocellulaire (1995) A comparison of lipiodol chemoembolization and conservative treatment for unresectable hepatocellular carcinoma. N Engl J Med 332:1256–1261
Hussain SM, Zondervan PE, Ijzermans JNM et al. (2002) Benign versus malignant hepatic nodules: MR imaging findings with pathologic correlation. Radiographics 22:1023–1039
International Working Party (1995) Terminology of nodular hepatocellular lesions. Hepatology 22:983–993
Jenkins RL, Johnson LB, Lewis WD (1994) Surgical approach to benign liver tumors. Semin Liver Dis 14:178–189
Jonas S, Bechstein WO, Steinmüller T et al. (2001) Vascular invasion and histopathologic grading determine outcome after liver transplantation for hepatocellular carcinoma in cirrhosis. Hepatology 33:1080–1086
Kouroumalis E, Skordilis P, Thermos K et al. (1998) Treatment of hepatocellular carcinoma with octreotide: a randomised controlled study. Gut 42:442–447
Lam CM, Lo CM, Yuen WK et al. (1998) Prolonged survival in selected patients following surgical resection for pulmonary metastasis from hepatocellular carcinoma. BrJ Surg 85: 1198–2000
Livraghi T, Goldberg SN, Lazzaroni S et al. (1999) Small hepatocellular carcinoma: treatment with radiofrequency ablation versus ethanol injection. Radiology 210:655–661
Llovet JM, Real MI, Montana X et al. (2002) Arterial embolisation or chemoembolisation versus symptomatic treatment in patients with unresectable hepatocellular carcinoma: a randomised controlled trial. Lancet 359:1734–1739
Lo CM, Ngan H, Tso WK et al. (2002) Randomized controlled trial of transarterial lipiodol chemoembolization for unresectable hepatocellular carcinoma. Hepatology 35:1164–1171
Marrero JA (2003) Hepatocellular carcinoma. Curr Opin Gastroenterol 19:243–249
Mazzaferro V, Regalia E, Doci R et al. (1996) Liver transplantation for the treatment of small hepatocellular carcinomas in patients with cirrhosis. N Engl J Med 334:693–699
Okuda K, Ohtsuki T, Obata H et al. (1985) Natural history of hepatocellular carcinoma and prognosis in relation to treatment. Cancer 56:918–928
Reimer P, Jähnke N, Fiebich M et al. (2000) Hepatic lesion detection and characterization: Value of nonenhanced MR imaging, superparamegnetic iron oxideenhanced MR imaging, and spiral CT-ROC analysis. Radiology 217:152–158
Shiratori Y, Shijna S, Teratani T et al. (2003) Interferon therapy after tumor ablation improves prognosis in patients with hepatocellular carcinoma associated with hepatitis C virus. Ann Intern Med 138:299–306
Sun HC, Tang ZY (2003) Preventive treatment for recurrence after curative resection of hepatocellular carcinoma — a literature review of randomized controlled trials. World J Gastroenterol 9:635–640
The Cancer of the Liver Italian Program (CLIP) Investigators (2000). Prospective validation of the CLIP score: a new prognostic system for patients with cirrhosis and hepatocellular carcinoma. Hepatology 31:840–845
Vilana R, Bruix J, Bru C et al. (1992) Tumor size determines the efficacy of percutaneous ethanol injection for the treatment of small hepatocellular carcinoma. Hepatology 16:353–357
Vogl TJ, Hammerstingl R, Schwarz W et al. (1996) Superparamagnetic iron oxideenhanced versus gadoliniumenhanced MRI imaging for differential diagnosis of focal liver lesions. Radiology 198:881–887
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2007 Springer Medizin Verlag Heidelberg
About this chapter
Cite this chapter
Pape, UF., Berg, T., Wiedenmann, B. (2007). Benigne und maligne Neoplasien der Leber. In: Schölmerich, J. (eds) Medizinische Therapie 2007 | 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48554-4_77
Download citation
DOI: https://doi.org/10.1007/978-3-540-48554-4_77
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-48553-7
Online ISBN: 978-3-540-48554-4
eBook Packages: Medicine (German Language)