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Das Vorliegen einer Struma entspricht einem Symptom und lässt zunächst keine Rückschlüsse auf die zugrunde liegende Schilddrüsenkrankheit oder den Funktionszustand der Schilddrüse zu. Die mit Abstand häufigste Form der Struma ist die euthyreote Struma, meist durch einen chronisch bestehenden Jodmangel verursacht. Sie ist definiert als nichtentzündliche, nichtmaligne Schilddrüsenvergrößerung bei euthyreoter Stoffwechsellage. Sie tritt klinisch auf als diffuse Struma oder als Struma nodosa.

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Literatur

  • Delange F (1998) Risks and benefits of iodine supplementation. Lancet 351: 923–924

    PubMed  CAS  Google Scholar 

  • Derwahl M, Studer H (2000) Multinodular goitre: »much more to it than simply iodine deficiency«. Baillieres Best Pract Res Clin Endocrinol Metab 14: 577–600

    Article  PubMed  CAS  Google Scholar 

  • Hegedus L, Nygaard B, Hansen JM (1999) Is routine thyroxine treatment to hinder postoperative recurrence of nontoxic goiter justified? J Clin Endocrinol Metab 84: 756–760

    Article  PubMed  CAS  Google Scholar 

  • Hintze G, Emrich D, Köbberling J (1989) Treatment of endemic goitre due to iodine deficiency with iodine, levothyroxine or both: results of a multicentre trial. Eur J Clin Invest 19: 527–534

    Article  PubMed  CAS  Google Scholar 

  • Kahaly G, Dienes HP, Beyer J, Hommel G (1997) Randomized, double blind, placebocontrolled trial of low dose iodide in endemic goiter. J Clin Endocrinol Metab 82: 4049–4053

    Article  PubMed  CAS  Google Scholar 

  • Leitlinien der Deutschen Gesellschaft für Chirurgie (1998) Therapie der benignen Struma. AWMF online, http://www.leitlinien.net

    Google Scholar 

  • Papini E, Petrucci L, Guglielmi R et al. (1998) Longterm changes in nodular goiter: a 5-year prospective randomized trial of levothyroxine suppressive therapy for benign cold thyroid nodules. J Clin Endocrinol Metab 83:780–783

    Article  PubMed  CAS  Google Scholar 

  • Quadbeck B, Pruellage J, Roggenbuck U et al. (2002) Longterm followup of thyroid nodule growth. Exp Clin Endocrinol Diabetes 110: 348–354

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Abraham P, Avenell A, Park CM, Watson WA, Bevan JS (2005) A systematic review of drug therapy for Graves’ hyperthyroidism. Eur J Endocrinol 153: 489–498

    Article  PubMed  CAS  Google Scholar 

  • Ando T, Latif R, Davies TF (2005) Thyrotropin receptor antibodies: new insights into their actions and clinical relevance. Best Pract Res Clin Endocrinol Metab 19: 33–52

    Article  PubMed  CAS  Google Scholar 

  • Belfiore A, Russo D, Vigneri R, Filetti S (2001) Graves’ disease, thyroid nodules and thyroid cancer. Clin Endocrinol (Oxf) 55: 711–718

    Article  CAS  Google Scholar 

  • Cooper DS (2005) Antithyroid drugs. N Engl J Med 352:905–917

    Article  PubMed  CAS  Google Scholar 

  • Feldt-Rasmussen U, Schleusener H, Carayon P(1994) Metaanalysis evaluation of the impact of thyrotropin receptor antibodies on long term remission after medical therapy of Graves’ disease. J Clin Endocrinol Metab 78: 98–102

    Article  PubMed  CAS  Google Scholar 

  • Hoermann R, Quadbeck B, Roggenbuck U et al. (2002) Relapse of Graves’ disease after successful outcome of antithyroid drug therapy: results of a prospective randomized study on the use of levothyroxine. Thyroid 12: 1119–1128

    Article  PubMed  CAS  Google Scholar 

  • Horacek J, Franklyn JA (2003) Radioiodine treatment of Graves’ hyperthyroidism. J Clin Endocrinol Metab 88: 6113

    Article  PubMed  CAS  Google Scholar 

  • Lazarus JH (2005) Thyroid disorders associated with pregnancy: etiology, diagnosis, and management. Treat Endocrinol 4:31–41

    Article  PubMed  Google Scholar 

  • Leitlinien der Deutschen GesellschaftfürNuklearmedizin (2004) Radiojodtherapie gutartiger Schilddrüsenkrankheiten. AWMF online, http://www.leitlinien.net

    Google Scholar 

  • Palit TK, Miller CC 3rd, Miltenburg DM (2000) The efficacy of thyroidectomy for Graves’ disease: A metaanalysis. J Surg Res 90:161–165

    Article  PubMed  CAS  Google Scholar 

  • Spitzweg C, Rossmuller B, Heufelder AE (1998) Radioiodine therapy and Graves’ ophthalmopathy. Thyroid 8:1193

    PubMed  CAS  Google Scholar 

  • Vestergaard P (2002) Smoking and thyroid disorders — a metaanalysis. Eur J Endocrinol 146:153–161

    Article  PubMed  CAS  Google Scholar 

  • Weetman AP (2000) Graves’ disease. N Engl J Med 343: 1236–1248

    Article  PubMed  CAS  Google Scholar 

  • Witte J, Goretzki PE, Dotzenrath C, Simon D, Felis P, Neubauer M, Roher HD (2000) Surgery for Graves’ disease: total versus subtotal thyroidectomy — results of a prospective randomized trial. World J Surg 24: 1303–1311

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Bartalena L, Marcocci C, Tanda ML et al. (1998) Cigarette smoking and treatment outcomes in Graves ophthalmopathy. Ann Intern Med 129: 632–635

    PubMed  CAS  Google Scholar 

  • Bartalena L (2005) Editorial: glucocorticoids for Graves’ ophthalmopathy: how and when. J Clin Endocrinol Metab 90: 5497–5499

    Article  PubMed  CAS  Google Scholar 

  • Gorman CA, Garrity JA, Fatourechi V et al. (2001) A prospective, randomized, doubleblind, placebocontrolled study of orbital radiotherapy for Graves’ ophthalmopathy. Ophthalmology 108:1523–1534

    Article  PubMed  CAS  Google Scholar 

  • Heufelder AE (2000) Pathogenesis of ophthalmopathy in autoimmune thyroid disease. Rev Endocr Metab Disord 1: 87–95

    Article  PubMed  CAS  Google Scholar 

  • Kahaly GJ, Rosler HP, Pitz S, Hommel G (2000) Low-versus high-dose radiotherapy for Graves’ ophthalmopathy: a randomized, single blind trial. J Clin Endocrinol Metab 85:102–108

    Article  PubMed  CAS  Google Scholar 

  • Krassas GE, Heufelder AE (2001) Immunosuppressive therapy in patients with thyroid eye disease: an overview of current concepts. Eur J Endocrinol 144:311–318

    Article  PubMed  CAS  Google Scholar 

  • Marcocci C, Bartalena L, Tanda ML et al. (2000) Radiotherapy for Graves’ orbitopathy: randomised placebocontrolled study. Lancet 355: 1505–1509

    Article  Google Scholar 

  • Prummel MF, Mourits MP, Blank L, Berghout A, Koornneef L, Wiersinga WM (1993) Randomized doubleblind trial of prednisone versus radiotherapy in Graves’ ophthalmopathy. Lancet 342: 949–954

    Article  PubMed  CAS  Google Scholar 

  • Prummel MF, Terwee CB, Gerding MN et al. (2004) A randomized controlled trial of orbital radiotherapy versus sham irradiation in patients with mild Graves’ ophthalmopathy. J Clin Endocrinol Metab 89: 15–20

    Article  PubMed  CAS  Google Scholar 

  • Wiersinga WM, Perros P, Kahaly GJ, Mourits MP, Baldeschi L, Boboridis K, Boschi A, Dickinson AJ, Kendall-Taylor P, Krassas GE, Lane CM, Lazarus JH, Marcocci C, Marino M, Nardi M, Neoh C, Orgiazzi J, Pinchera A, Pitz S, Prummel MF, Sartini MS, Stahl M, von Arx G (2006) Clinical assessment of patients with Graves’ orbitopathy: the European Group on Graves’ Orbitopathy recommendations to generalists, specialists and clinical researchers. Eur J Endocrinol 155: 387–389

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Brabant G, Kahaly G, Schicha H, Reiners C (2006) Milde Formen der Schilddrüsenfehlfunktion. Ursachen, Diagnostik, Vorgehen. Dtsch Ärzteblatt 103: 2110–2115

    Google Scholar 

  • Corvilain B, Van Sande J, Dumont JE, Bourdoux P, Ermans AM (1998) Autonomy in endemic goiter. Thyroid 8:107–113

    PubMed  CAS  Google Scholar 

  • Derwahl M, Studer H (2000) Multinodular goitre: »much more to it than simply iodine deficiency«. Baillieres Best Pract Res Clin Endocrinol Metab 14: 577–600

    Article  PubMed  CAS  Google Scholar 

  • Emrich D (1999) Jodmangelstruma mit funktioneller Autonomie. Diagnostische und therapeutische Indikationen. Nuklearmedizin 38: 3–5

    PubMed  CAS  Google Scholar 

  • Krohn K, Paschke R (2001) Clinical review 133: Progress in understanding the etiology of thyroid autonomy. J Clin Endocrinol Metab 86: 3336–3345

    Article  PubMed  CAS  Google Scholar 

  • Leitlinien der Deutschen GesellschaftfürNuklearmedizin (2004) Radiojodtherapie gutartiger Schilddrüsenkrankheiten. AWMF online, http://www.leitlinien.net.

    Google Scholar 

  • Papini E, Panunzi C, Pacella CM, Bizzarri G, Fabbrini R, Petrucci L, Pisicchio G, Nardi F (1993) Percutaneous ultrasoundguided ethanol injection: a new treatment of toxic autonomously functioning thyroid nodules? J Clin Endocrinol Metab 76: 411–416

    Article  PubMed  CAS  Google Scholar 

  • Rendl J, Saller B (2001) Schilddrüse und Röntgenkontrastmittel — Pathophysiologie, Häufigkeit und medikamentöse Prophylaxe der iodinduzierten Hyperthyreose. Deutsches Ärzteblatt 98:316–320

    Google Scholar 

  • Roti E, Uberti ED (2001) Iodine excess and hyperthyroidism. Thyroid 11: 493–500

    Article  PubMed  CAS  Google Scholar 

  • Sandrock D, Olbricht T, Emrich D, Benker G, Reinwein D (1993) Longterm followup in patients with autonomous thyroid adenoma. Acta Endocrinol (Copenh) 128:51–55

    PubMed  CAS  Google Scholar 

  • Schumm-Draeger PM (1998) Ultrasoundguided percutaneous ethanol injection in the treatment of autonomous thyroid nodules — a review. Exp Clin Endocrinol Diabetes 106: S59–62

    Article  PubMed  CAS  Google Scholar 

  • Toft AD (2001) Clinical practice. Subclinical hyperthyroidism. N Engl J Med 345: 512–516

    Article  PubMed  CAS  Google Scholar 

  • Zingrillo M, Torlontano M, Ghiggi MR, Frusciante V, Varraso A, Liuzzi A, Trischitta V (2000) Radioiodine and percutaneous ethanol injection in the treatment of large toxic thyroid nodule: a longterm study. Thyroid 10: 985–989

    PubMed  CAS  Google Scholar 

Literatur

  • Dayan CM, Daniels GH (1996) Chronic autoimmune thyroiditis. N Engl J Med 335: 99–107

    Article  PubMed  CAS  Google Scholar 

  • Fatourechi V (2001) Subclinical thyroid disease. Mayo Clin Proc 76:413–416;quiz 416—417

    PubMed  CAS  Google Scholar 

  • Mandac JC, Chaudhry S, Sherman KE, Tomer Y (2006) The clinical and physiological spectrum of interferonalpha induced thyroiditis: toward a new classification. Hepatology 43:661–672

    Article  PubMed  CAS  Google Scholar 

  • Martino E, Bartalena L, Bogazzi F, Braverman LE (2001) The effects of amiodarone on the thyroid. Endocr Rev 22: 240–254

    Article  PubMed  CAS  Google Scholar 

  • Muller AF, Drexhage HA, Berghout A (2002) Postpartum thyroiditis and autoimmune thyroiditis in women of childbearing age: recent insights and consequences for antenatal and postnatal care. Endocr Rev 22: 605–630

    Article  Google Scholar 

  • Roberts CG, Ladenson PW (2004) Hypothyroidism. Lancet 363: 793–803

    Article  PubMed  CAS  Google Scholar 

  • Roti E, Uberti E (2002) Postpartum thyroiditis — a clinical update. Eur J Endocrinol 146: 275–279

    Article  PubMed  CAS  Google Scholar 

  • Schumm-Draeger PM (1998) Thyreoiditis. Formen, Diagnostik, Therapie. Internist (Berl) 39: 594–598

    Article  PubMed  CAS  Google Scholar 

  • Toft AD (1994) Thyroxine therapy. N Engl J Med 331: 174–180

    Article  PubMed  CAS  Google Scholar 

  • Walfish PG (1997) Thyroiditis. Curr Ther Endocrinol Metab 6:117–122

    PubMed  CAS  Google Scholar 

  • Vanderpump MP, Tunbridge WM, French JM et al. (1995) The incidence of thyroid disorders in the community: a twentyyear followup of the Whickham Survey. Clin Endocrinol (Oxf) 43: 55–68

    CAS  Google Scholar 

Literatur

  • Biermann M, Pixberg MK, Dorr U, Dietlein M, Schlemmer H, Grimm J, Zajic T, Nestle U, Ladner S, Sepehr-Rezai S, Rosenbaum S, Puskas C, Fostitsch P, Heinecke A, Schuck A, Willich N, Schmid KW, Dralle H, Schober O (2005) Guidelines on radioiodine therapy for differentiated thyroid carcinoma: impact on clinical practice. Nuklearmedizin 44:229–234,236–227

    PubMed  CAS  Google Scholar 

  • Brandi ML, Gagel RF, Angeli A et al. (2001) Guidelines for diagnosis and therapy of MEN type 1 and type 2. J Clin Endocrinol Metab 86:5658–5671

    Article  PubMed  CAS  Google Scholar 

  • Gimm O, Sutter T, Dralle H (2001) Diagnosis and therapy of sporadic and familial medullary thyroid carcinoma. J Cancer Res Clin Oncol 127:156–165

    Article  PubMed  CAS  Google Scholar 

  • Giuffrida D, Gharib H (2000) Anaplastic thyroid carcinoma: current diagnosis and treatment. Ann Oncol 11:1083–1089

    Article  PubMed  CAS  Google Scholar 

  • Hoelzer S, Reiners C, Mann K, Bamberg M, Rothmund M, Dudeck J, Stewart AV, Hundahl SA (2000) Patterns of care for patients with primary differentiated carcinoma of the thyroid gland treated in Germany during 1996. U.S. and German Thyroid Cancer Group. Cancer 89:192–201

    Article  Google Scholar 

  • Interdisziplinäre Leitlinie der Deutschen Krebsgesellschaft und der Deutschen Gesellschaft für Chirurgie (2002) Maligne Schilddrüsentumoren. AWMF online, http://www.leitlinien.net

    Google Scholar 

  • Kebebew E, Clark OH (2000) Medullary thyroid cancer. Curr Treat Options Oncol 1:359–367

    Article  PubMed  CAS  Google Scholar 

  • Larsen PR (2006) New guidelines for patients with thyroid nodules and differentiated thyroid cancer. Nat Clin Pract Endocrinol Metab 2: 297

    Article  PubMed  Google Scholar 

  • Lawrence W Jr, Kaplan BJ (2002) Diagnosis and management of patients with thyroid nodules. J Surg Oncol 80:157–170

    Article  PubMed  Google Scholar 

  • Mann K (2002) Diagnostik und Therapie differenzierter Schilddrüsenkarzinome. Internist (Berl) 43:174–185

    Article  PubMed  CAS  Google Scholar 

  • Mazzaferri EL (1999) An overview of the management of papillary and follicular thyroid carcinoma. Thyroid 9:421–427

    PubMed  CAS  Google Scholar 

  • Mazzaferri EL, Kloos RT (2000) Using recombinant human TSH in the management of welldifferentiated thyroid cancer: current strategies and future directions. Thyroid 10:767–778

    Article  PubMed  CAS  Google Scholar 

  • Pacini F, Schlumberger M, Dralle H, Elisei R, Smit JW, Wiersinga W (2006) European consensus for the management of patients with differentiated thyroid carcinoma of the follicular epithelium. Eur J Endocrinol 154:787–803

    Article  PubMed  CAS  Google Scholar 

  • Saller B (2001) Treatment with cytotoxic drugs. In: Biersack HJ, Grünwald F, Hrsg. Thyroid cancer. Springer, Berlin Heidelberg New York Tokyo, pp 139–151

    Google Scholar 

  • Schmid KW, Shen SY, Görges R et al. (2003) Tumoren der Schilldrüse. Pathologe 24:357–372

    Article  PubMed  CAS  Google Scholar 

  • Trupka A, Vogelsang H, Negele T, Hallfeldt K, Kopp R, Fürst H (2006) Operative Primärtherapie differenzierter Schilddrüsenkarzinome. Mannual Endokrine Tumoren. W. Zucker-schwerdt, Verlag München

    Google Scholar 

Literatur

Literatur

  • Betterle C, Dal Pra C, Mantero F, Zanchetta R (2002) Autoimmune adrenal insufficiency and autoimmune polyendocrine syndromes: autoantibodies, autoantigens, and their applicability in diagnosis and disease prediction. Endocr Rev 23:327–364

    Article  PubMed  CAS  Google Scholar 

Literatur

  • Reichmann I, Frilling A, Hörmann R, Krause U, Broelsch CE (2001) Frühoperation als Behandlungsmassnahme der thyreotox-ischen Krise. Chirurg 72:402–407

    Article  PubMed  CAS  Google Scholar 

  • Ringel MD (2001) Management of hypothyroidism and hyperthyroidism in the intensive care unit. Crit Care Clin 17:59–74

    Article  PubMed  CAS  Google Scholar 

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Saller, B., Janßen, O.E. (2007). Schilddrüse. In: Schölmerich, J. (eds) Medizinische Therapie 2007 | 2008. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-48554-4_60

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