Definition
Vanadium, a member of group VB and in the 4th period of the periodic table is a first transition series, d-block, grayish metallic element with an atomic number of 23 and forms different oxidation states of –1, 0, +2, +3, +4 and +5. The oxidation states +3 (vanadic), +4 (vanadyl) and +5 (vanadate) being most common, the oxidation state +4 is most stable in biological systems. Vanadium is an endogenous constituent of most mammalian tissues and is further considered a dietary micronutrient. It is an essential element for the proper growth and development of mammals owing to its diverse physiological and biochemical functions.
Characteristics
The uniqueness of vanadium is that it is included in the list of 40 essential micronutrients required in small amounts for normal cell metabolism. Accordingly, it has been incorporated into many multinational pharmaceutical preparations for maintenance of normal health. Although micronutrients never have had pharmacological potencies, they...
This is a preview of subscription content, log in via an institution to check access.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Evangelou AM (2002) Vanadium in cancer treatment. Crit Rev Oncol Hematol 42:249–265
Chatterjee M, Bishayee A (1998) Vanadium – a new tool for cancer prevention. In: Nriagu JO (ed) Vanadium in the environment, part two, health effects. Wiley, New York, pp 347–390
Hamilton EE, Fanwick PE, Wilker JJ (2006) Alkylation of inorganic oxo compounds and insights on preventing DNA damage. J Am Chem Soc 128:3388–3395
Ray RS, Ghosh B, Rana A et al. (2006) Suppression of cell proliferation, induction of apoptosis and cell cycle arrest: chemopreventive activity of vanadium in vivo and in vitro. Int J Cancer 120:13–23
Chakraborty T, Chatterjee A, Rana A et al. (2007) Carcinogen-induced early molecular events and its implication in the initiation of chemical hepatocarcinogenesis in rats: chemopreventive role of vanadium on this process. Biochim Biophys Acta 1772:48–59
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2008 Springer-Verlag Berlin Heidelberg New York
About this entry
Cite this entry
Chatterjee, M. (2008). Vanadium. In: Schwab, M. (eds) Encyclopedia of Cancer. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47648-1_6149
Download citation
DOI: https://doi.org/10.1007/978-3-540-47648-1_6149
Publisher Name: Springer, Berlin, Heidelberg
Print ISBN: 978-3-540-36847-2
Online ISBN: 978-3-540-47648-1
eBook Packages: Biomedical and Life SciencesReference Module Biomedical and Life Sciences