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Secretory Proteins of Chironomus Salivary Glands: Structural Motifs and Assembly Characteristics of a Novel Biopolymer

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Structure, Cellular Synthesis and Assembly of Biopolymers

Part of the book series: Results and Problems in Cell Differentiation ((RESULTS,volume 19))

Abstract

Aquatic larvae of the midge, Chironomus (Diptera), historically have been known for the giant polytene chromosomes found in the nuclei of their salivary glands. More than a century ago, Balbiani (1881) described large puffs on these chromosomes. These puffs, referred to as Balbiani rings (BRs), were recognized by Beermann (1952, 1961) as loci of tissue-specific gene expression and are now known to be sites of intensive transcription (Pelling 1964; Case and Daneholt 1977; Grossbach 1977). Cytogenetic studies by Beermann (1961) and Grossbach (1969) led to the proposal that BRs contain genes encoding secretory proteins, the major product of the salivary gland. Secretory proteins assemble in vivo into insoluble silken threads that larvae use for feeding and construction of housing and pupation tubes.

The authors wish to dedicate this chapter to Professor Bertil Daneholt who, earlier in our careers, provided a stimulating atmosphere, freedom to inquire and encouragement to pursue experiments that brought us to our current understanding of the secretory proteins and their genes.

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Authors and Affiliations

  1. Department of Biochemistry, The University of Mississippi Medical Center, Jackson, MS, 39216-4505, USA

    Steven T. Case

  2. Department of Molecular Genetics, Medical Nobel Institutet, Karolinska Institute, Box 60400, S-10401, Stockholm, Sweden

    Lars Wieslander

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  1. Dept. of Biochemistry, Medical Center, The University of Mississippi, 2500 North State Street, Jackson, MS, 39216-4505, USA

    Steven T. Case

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Case, S.T., Wieslander, L. (1992). Secretory Proteins of Chironomus Salivary Glands: Structural Motifs and Assembly Characteristics of a Novel Biopolymer. In: Case, S.T. (eds) Structure, Cellular Synthesis and Assembly of Biopolymers. Results and Problems in Cell Differentiation, vol 19. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-47207-0_7

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